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Multimodal combinatorial therapy merges different modes of therapies in one platform, which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatment efficiency. Here we report a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive chemotherapy. By super-assembly of mesoporous silica nanoparticles (MSN) with metal-phenolic networks (MPN), anti-cancer drugs can be loaded in the MSN matrix, while the outer MPN coating allows dual photothermal and pH-responsive properties. Upon near-infrared light irradiation, the MSN@MPN nanoplatform exhibits excellent photothermal effect, and demonstrates outstanding pH-triggered drug release property. In vitro cell experiments suggest the MSN@MPN system exhibits superior biocompatibility and can effectively kill tumor cells after loading anti-cancer drugs. Consequently, the MSN@MPN system shows promising prospects in clinical application for tumor therapy.

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Publication history

Received: 10 November 2019
Revised: 23 February 2020
Accepted: 25 February 2020
Published: 11 April 2020
Issue date: April 2020

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© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020

Acknowledgements

This work was supported by the National Key Research and Development Program of China (Nos. 2019YFC1604600, 2017YFA0206901, 2017YFA0206900), the National Natural Science Foundation of China (Nos. 21705027, 21974029, and 81830052), the Construction project of Shanghai Key Laboratory of Molecular Imaging (No. 18DZ2260400), the Shanghai Municipal Education Commission (Class II Plateau Disciplinary Construction Program of Medical Technology of SUMHS, 2018-2020), the Australia National Health and Medical Research Council (NHMRC) (No. APP1163786), the Scientia Fellowship program at UNSW, the MCTL Visiting Fellowship Program, Shanghai Key Laboratory of Molecular Imaging (No. 18DZ2260400), the Natural Science Foundation of Shanghai, and the Recruitment Program of Global Experts of China and Shanghai.

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Email: nanores@tup.tsinghua.edu.cn

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