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Review Article

Emerging wet electrohydrodynamic approaches for versatile bioactive 3D interfaces

Mehmet Berat Taskin2, Lasse Hyldgaard Klausen2, Mingdong Dong2, Menglin Chen1,2( )
Department of Engineering, Aarhus University, 8000 Aarhus C, Denmark
Interdisciplinary Nanoscience Center, Aarhus University, 8000 Aarhus C, Denmark
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Abstract

There is a compelling need for delicate nanomaterial design with various intricate functions and applications. Electrohydrodynamics applies electrostatic force to overcome the surface tension of a liquid jet, shrinking the jet through intrinsic jetting instability into submicron fibers or spheres, with versatility from a huge selection of materials, feasibility of extracellular matrix structure mimicry and multi-compartmentalization for tissue engineering and drug delivery. The process typically involves the collection and drying of fibers at a solid substrate, but the introduction of a liquid phase collection by replacing the solid collector with a coagulation bath can introduce a variety of new opportunities for both chemical and physical functionalizations in one single step. The so-called wet electrohydrodynamics is an emerging technique that enables a facile, homogeneous functionalization of the intrinsic large surface area of the submicron fibers/spheres. With a thorough literature sweep, we herein highlight the three main engineering features integrated through the single step wet electrospinning process in terms of creating functional biomaterials: (i) The fabrication of 3D macrostructures, (ii) in situ chemical functionalization, and (iii) tunable nano-topography. Through an emerging technique, wet electrohydrodynamics has demonstrated a great potential in interdisciplinary research for the development of functional 3D interfaces and materials with pertinent applications in all fields where secondary structured, functional surface is desired. Among these, engineered biomaterials bridging materials science with biology have already shown particular potential.

Keywords

wet-electrohydrodynamics3D macrostructurein-situ functionalizationnanotopographical alterationtissue engineeringnanotechnology

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Nano Research
Volume 13 Issue 2,
February 2020
Pages 315-327
DOI: 10.1007/s12274-020-2635-x
Cite this article:
Taskin MB, Klausen LH, Dong M, et al. Emerging wet electrohydrodynamic approaches for versatile bioactive 3D interfaces. Nano Research, 2020, 13(2): 315-327. https://doi.org/10.1007/s12274-020-2635-x
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Biomaterials Drug deliveryTissue

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Received: 07 November 2019
Revised: 16 December 2019
Accepted: 01 January 2020
Published: 18 January 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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