Silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes with an enhanced antibacterial activity for killing drug-resistant bacteria

Yu Zhu; Jia Xu; Yanmao Wang; Cang Chen; Hongchen Gu; Yimin Chai; Yao Wang

doi:10.1007/s12274-020-2621-3

Nano Research 2020, 13(2): 389-400 https://doi.org/10.1007/s12274-020-2621-3

Research Article | Issue | Published: 08 January 2020

Silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes with an enhanced antibacterial activity for killing drug-resistant bacteria

Show Author's Information Hide Author's Information Yu Zhu^{^§}, Jia Xu^{^§}, Yanmao Wang, Cang Chen, Hongchen Gu, Yimin Chai(

), Yao Wang(

)

Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China

^§ Yu Zhu and Jia Xu contributed equally to this work.

Keywords:

silver nanoparticles, single-walled carbon nanotubes, drug-resistant bacteria, enhanced antibacterial activity, wound infections

Topics:

Biocompatibility Controlled drug delivery Cytology Escherichia coli Mesoporous materials Metal ions Metal nanoparticles Nanotubes Silica Silver nanoparticles

Cite this article:

Zhu Y, Xu J, Wang Y, et al. Silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes with an enhanced antibacterial activity for killing drug-resistant bacteria. Nano Research, 2020, 13(2): 389-400. https://doi.org/10.1007/s12274-020-2621-3

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Abstract Full text Electronic supplementary material About this article

Abstract

The mounting threat of antibiotic-resistant bacterial infections has made it imperative to develop innovative antibacterial strategies. Here we propose a novel antibacterial nanoplatform of silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes constructed via a N-[3-(trimethoxysilyl)propyl]ethylene diamine (TSD)-mediated method (SWCNTs@mSiO₂-TSD@Ag). In this system, the outer mesoporous silica shells are able to improve the dispersibility of SWCNTs, which will increase their contact area with bacteria cell walls. Meanwhile, the large number of mesopores in silica layers act as microreactors for in situ synthesis of Ag NPs with controlled small size and uniform distribution, which induces an enhanced antibacterial activity. Compared with TSD modified mesoporous silica coated single-walled carbon nanotubes (SWCNTs@mSiO₂-TSD) and commercial Ag NPs, this combination nanosystem of SWCNTs@mSiO₂-TSD@Ag exhibits much stronger antibacterial performance against multi-drug-resistant bacteria Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro through damaging the bacterial cell membranes and a fast release of silver ions. Furthermore, the in vivo rat skin infection model verifies that SWCNTs@mSiO₂-TSD@Ag have remarkably improved abilities of bacterial clearance, wound healing promoting as well as outstanding biocompatibility. Therefore, this novel nanoplatform indicates promising potentials as a safe and powerful tool for the treatment of clinical drug-resistant infections.

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About this article

Silver nanoparticles-decorated and mesoporous silica coated single-walled carbon nanotubes with an enhanced antibacterial activity for killing drug-resistant bacteria

Show Author's information Hide Author's Information Yu Zhu^{^§}, Jia Xu^{^§}, Yanmao Wang, Cang Chen, Hongchen Gu, Yimin Chai(

), Yao Wang(

)

Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China

^§ Yu Zhu and Jia Xu contributed equally to this work.

Abstract

Keywords: silver nanoparticles, single-walled carbon nanotubes, drug-resistant bacteria, enhanced antibacterial activity, wound infections

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Acknowledgements

Publication history

Received: 22 October 2019

Revised: 17 December 2019

Accepted: 21 December 2019

Published: 08 January 2020

Issue date: February 2020

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Acknowledgements

This work is supported by the National Natural Science Foundation of China (Nos. 51802192, 81802156, and 81772338), the Interdisciplinary Program of Shanghai Jiao Tong University (No. YG2017ZD05), Natural Science Foundation of Shanghai (No. 19ZR1474800), Shanghai Sailing Program (No. 18YF1410700), and Innovation Research Plan supported by Shanghai Municipal Education Commission (No. ZXWF082101). The authors would like to acknowledge the Instrumental Analysis Center of Shanghai Jiao Tong University for the characterization of materials, and Juanxi Gu of Shanghai Jiao Tong University for her graphic assistance.