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Nano Research 2019, 12(6): 1251-1265 https://doi.org/10.1007/s12274-019-2314-y
Review Article | Issue | Published: 29 May 2019

Luminescent metal nanoclusters for biomedical applications

Show Author's Information Yu Su1,  Tiantian Xue1,  Yuxin Liu1,  Jinxia Qi1,  Rongchao Jin2( ),  Zhenkun Lin1( )
Center of Scientific Research,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325035,China;
Department of Chemistry,Carnegie Mellon University,Pittsburgh, PA,15213,USA;
Keywords:
therapy, drug delivery, luminescence, metal nanoclusters, biomedicine, biomedical detection, bio-imaging
Topics:
BiocompatibilityControlled drug deliveryDiagnosisDiseasesDrug deliveryMedical applicationsMetalsNanoclustersNanostructured materialsTargeted drug delivery
Cite this article:
Su Y, Xue T, Liu Y, et al. Luminescent metal nanoclusters for biomedical applications. Nano Research, 2019, 12(6): 1251-1265. https://doi.org/10.1007/s12274-019-2314-y
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Abstract Full text About this article

Luminescent metal nanoclusters (NCs) have recently emerged as a novel class of luminescent nanomaterials and hold significant potential in biomedicine owing to their ultrasmall (< 2 nm) size, excellent photostability, and good biocompatibility. The recent rapid advances in the synthesis and functionalization of luminescent metal NCs have enabled scientists to develop colorful nanomaterials and nanodevices for a wide range of biomedical applications. In this review, we summarize the characteristics and advantages of luminescence from metal NCs, and highlight their applications in biomedicine. We focus on the research in biomedical detection, bio-imaging, drug delivery, and therapy, especially for the advances in the last five years. Luminescent metal NCs display a series of unique superiorities in biomedical applications, and the recent achievements have brought a lot of benefits to the diagnosis and treatment of clinical diseases, especially for tumors and cancers. Finally, we put forward the main challenges that currently still hinder the basic science studies and the practical development of luminescent metal NCs in biomedical applications. Overall, we expect that luminescent metal NCs will play a much more important role in future biomedicine and clinical applications.


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About this article

Luminescent metal nanoclusters for biomedical applications

Show Author's information Yu Su1, Tiantian Xue1, Yuxin Liu1, Jinxia Qi1, Rongchao Jin2( ), Zhenkun Lin1( )
Center of Scientific Research,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325035,China;
Department of Chemistry,Carnegie Mellon University,Pittsburgh, PA,15213,USA;

Abstract

Luminescent metal nanoclusters (NCs) have recently emerged as a novel class of luminescent nanomaterials and hold significant potential in biomedicine owing to their ultrasmall (< 2 nm) size, excellent photostability, and good biocompatibility. The recent rapid advances in the synthesis and functionalization of luminescent metal NCs have enabled scientists to develop colorful nanomaterials and nanodevices for a wide range of biomedical applications. In this review, we summarize the characteristics and advantages of luminescence from metal NCs, and highlight their applications in biomedicine. We focus on the research in biomedical detection, bio-imaging, drug delivery, and therapy, especially for the advances in the last five years. Luminescent metal NCs display a series of unique superiorities in biomedical applications, and the recent achievements have brought a lot of benefits to the diagnosis and treatment of clinical diseases, especially for tumors and cancers. Finally, we put forward the main challenges that currently still hinder the basic science studies and the practical development of luminescent metal NCs in biomedical applications. Overall, we expect that luminescent metal NCs will play a much more important role in future biomedicine and clinical applications.

Keywords: therapy, drug delivery, luminescence, metal nanoclusters, biomedicine, biomedical detection, bio-imaging

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Publication history
Copyright
Acknowledgements

Publication history

Received: 23 November 2018
Revised: 21 January 2019
Accepted: 26 January 2019
Published: 29 May 2019
Issue date: June 2019

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Acknowledgements

Acknowledgements

Z. K. L. acknowledges the financial support from the National Natural Science Foundation of China (No. 21107083), Zhejiang Public Welfare Technology Research Project (No. LGF19H030014), and Zhejiang Medical and Health Science & Technology Project (No. 2018PY032). R. C. J. acknowledges the support from the AFOSR.

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