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Nano Research 2019, 12(5): 973-990 https://doi.org/10.1007/s12274-019-2300-4
Review Article | Issue | Published: 04 March 2019

Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

Show Author's Information Abdullah A. Ghawanmeh1,  Gomaa A. M. Ali1,2,  H. Algarni3,4,  Shaheen M. Sarkar5,  Kwok Feng Chong1( )
Faculty of Industrial Sciences & Technology,Universiti Malaysia Pahang,Gambang,26300,Kuantan, Malaysia;
Chemistry Department,Faculty of Science, Al-Azhar University,Assiut,71524,Egypt;
Department of Physics, Faculty of Sciences,King Khalid University,Abha 61413, P. O. Box,9004,Saudi Arabia;
Research Center for Advanced Materials Science (RCAMS),King Khalid University,Abha 61413, P. O. Box,9004,Saudi Arabia;
Bernal Institute, Department of Chemical Sciences,University of Limerick,Castletroy V94, Limerick,Ireland;
Keywords:
graphene oxide, drug delivery, hydrogel, nanocarrier, cancer nanotechnology
Topics:
Bioactivity BiocompatibilityBiodegradability Biodegradable polymersCarbon dioxideControlled drug deliveryCytologyDiseasesDrug deliveryDrug productsGraphene
Cite this article:
Ghawanmeh AA, Ali GAM, Algarni H, et al. Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery. Nano Research, 2019, 12(5): 973-990. https://doi.org/10.1007/s12274-019-2300-4
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Abstract Full text About this article

Graphene oxide (GO) possesses excellent mechanical strength, biocompatibility, colloidal stability, large surface area and high adsorption capability. It has driven to cancer nanotechnology to defeat cancer therapy obstacles, via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier, and controllable release of anticancer drugs. Specifically, the surface of GO affords π-π stacking and hydrophilic interactions with anticancer drugs. Additionally, modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability, drug loading, and target delivery. In this review, GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies, preparation methods, the model drug, polymer conjugation and modification with targeting ligands. Moreover, swelling kinetics, drug release profile and biological activity in vivo and in vitro are discussed. The biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio interfaces. Apart from that, the clinical potential of GO based hydrogels and its major challenges are addressed in detail. Finally, this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug delivery. It is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels, such as large surface area, chemical purity, high loading capacity of drug, chemical stability, and the nature of lipophilic for cell membrane penetration.


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About this article

Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

Show Author's information Abdullah A. Ghawanmeh1, Gomaa A. M. Ali1,2, H. Algarni3,4, Shaheen M. Sarkar5, Kwok Feng Chong1( )
Faculty of Industrial Sciences & Technology,Universiti Malaysia Pahang,Gambang,26300,Kuantan, Malaysia;
Chemistry Department,Faculty of Science, Al-Azhar University,Assiut,71524,Egypt;
Department of Physics, Faculty of Sciences,King Khalid University,Abha 61413, P. O. Box,9004,Saudi Arabia;
Research Center for Advanced Materials Science (RCAMS),King Khalid University,Abha 61413, P. O. Box,9004,Saudi Arabia;
Bernal Institute, Department of Chemical Sciences,University of Limerick,Castletroy V94, Limerick,Ireland;

Abstract

Graphene oxide (GO) possesses excellent mechanical strength, biocompatibility, colloidal stability, large surface area and high adsorption capability. It has driven to cancer nanotechnology to defeat cancer therapy obstacles, via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier, and controllable release of anticancer drugs. Specifically, the surface of GO affords π-π stacking and hydrophilic interactions with anticancer drugs. Additionally, modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability, drug loading, and target delivery. In this review, GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies, preparation methods, the model drug, polymer conjugation and modification with targeting ligands. Moreover, swelling kinetics, drug release profile and biological activity in vivo and in vitro are discussed. The biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio interfaces. Apart from that, the clinical potential of GO based hydrogels and its major challenges are addressed in detail. Finally, this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug delivery. It is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels, such as large surface area, chemical purity, high loading capacity of drug, chemical stability, and the nature of lipophilic for cell membrane penetration.

Keywords: graphene oxide, drug delivery, hydrogel, nanocarrier, cancer nanotechnology

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Publication history
Copyright
Acknowledgements

Publication history

Received: 22 October 2018
Revised: 12 January 2019
Accepted: 15 January 2019
Published: 04 March 2019
Issue date: May 2019

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Acknowledgements

Acknowledgements

The authors would like to acknowledge the funding from the Ministry of Education Malaysia in the form of FRGS (RDU160118: FRGS/1/2016/STG07/UMP/02/3, RDU170113: FRGS/1/2017/STG07/UMP/01/1), Universiti Malaysia Pahang grant RDU170357 and King Khalid University, the Ministry of Education in Saudi Arabia for supporting this research through grant (RCAMS/KKU/002-18) under research center for advanced material science.

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