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Nano Research 2019, 12(4): 719-732 https://doi.org/10.1007/s12274-019-2286-y
Review Article | Issue | Published: 15 January 2019

Functionalization of AuMSS nanorods towards more effective cancer therapies

Show Author's Information Carolina F. Rodrigues1,§,  Telma A. Jacinto1,§,  André F. Moreira1,§,  Elisabete C. Costa1,  Sónia P. Migue1,  IIídio J. Correia1,2( )
CICS-UBI — Centro de Investigação em Ciências da Saúde,Universidade da Beira Interior,Covilhã,6200-506,Portugal;
CIEPQF — Departamento de Engenharia Química,Universidade de Coimbra, Rua 13 Sílvio Lima,Coimbra,3030-790,Portugal;

§ Carolina F. Rodrigues, Telma A. Jacinto, and André F. Moreira contributed equally to this work.

Keywords:
silica, gold nanorods, cancer, targeting, surface modifications
Topics:
BiocompatibilityBloodControlled drug deliveryDiseasesGoldInfrared devices Infrared radiation Medical nanotechnologyNanoparticlesNanorodsOncologySilicaSurface treatment
Cite this article:
Rodrigues CF, Jacinto TA, Moreira AF, et al. Functionalization of AuMSS nanorods towards more effective cancer therapies. Nano Research, 2019, 12(4): 719-732. https://doi.org/10.1007/s12274-019-2286-y
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Abstract Full text About this article

The application of nanoparticles as selective drug delivery platforms arises as one the most promising therapeutic strategies in the biomedical field. Such systems can encapsulate drugs, prevent its premature degradation, transport and promote the drugs specific delivery to the target site. Among the different nanostructures, gold-core mesoporous silica shell (AuMSS) nanorods have been one of the most explored due to their unique physical and chemical properties. The mesoporous silica biocompatibility, high surface area that can be easily functionalized, tubular pores that can store the drugs, conjugated with the intrinsic capacity of gold nanorod to absorb near-infrared radiation, allows the combination of hyperthermia (i.e., photothermal effect) with drug delivery, making them a nanoplatforms with a huge potential for cancer therapy. Nevertheless, the successful application of AuMSS nanoparticles as an effective cancer nanomedicine is hindered by the uncontrolled release of the therapeutic payloads, limited blood circulation time and unfavorable pharmacokinetics.

In this review, an overview of the modifications performed to improve the AuMSS nanorods application in nanomedicine is provided, highlighting the practical approaches that enhanced the AuMSS nanorods targeting, responsiveness to different stimuli, and blood circulation time. Further, the basics of AuMSS nanorods synthesis procedures, general properties, and its application in cancer therapy are also described.


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Abstract
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About this article

Functionalization of AuMSS nanorods towards more effective cancer therapies

Show Author's information Carolina F. Rodrigues1,§, Telma A. Jacinto1,§, André F. Moreira1,§, Elisabete C. Costa1, Sónia P. Migue1, IIídio J. Correia1,2( )
CICS-UBI — Centro de Investigação em Ciências da Saúde,Universidade da Beira Interior,Covilhã,6200-506,Portugal;
CIEPQF — Departamento de Engenharia Química,Universidade de Coimbra, Rua 13 Sílvio Lima,Coimbra,3030-790,Portugal;

§ Carolina F. Rodrigues, Telma A. Jacinto, and André F. Moreira contributed equally to this work.

Abstract

The application of nanoparticles as selective drug delivery platforms arises as one the most promising therapeutic strategies in the biomedical field. Such systems can encapsulate drugs, prevent its premature degradation, transport and promote the drugs specific delivery to the target site. Among the different nanostructures, gold-core mesoporous silica shell (AuMSS) nanorods have been one of the most explored due to their unique physical and chemical properties. The mesoporous silica biocompatibility, high surface area that can be easily functionalized, tubular pores that can store the drugs, conjugated with the intrinsic capacity of gold nanorod to absorb near-infrared radiation, allows the combination of hyperthermia (i.e., photothermal effect) with drug delivery, making them a nanoplatforms with a huge potential for cancer therapy. Nevertheless, the successful application of AuMSS nanoparticles as an effective cancer nanomedicine is hindered by the uncontrolled release of the therapeutic payloads, limited blood circulation time and unfavorable pharmacokinetics.

In this review, an overview of the modifications performed to improve the AuMSS nanorods application in nanomedicine is provided, highlighting the practical approaches that enhanced the AuMSS nanorods targeting, responsiveness to different stimuli, and blood circulation time. Further, the basics of AuMSS nanorods synthesis procedures, general properties, and its application in cancer therapy are also described.

Keywords: silica, gold nanorods, cancer, targeting, surface modifications

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Publication history
Copyright
Acknowledgements

Publication history

Received: 20 November 2018
Revised: 02 January 2019
Accepted: 03 January 2019
Published: 15 January 2019
Issue date: April 2019

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Acknowledgements

Acknowledgements

This work was supported by FEDER funds through the POCI—COMPETE 2020—Operational Programme Competitiveness and Internationalisation in Axis I—Strengthening research, technological development and innovation (Project POCI-01—0145-FEDER-007491) and National Funds by FCT—Foundation for Science and Technology (Project UID/Multi/00709/2013). A. F. M., S. P. M., and E. C. C. acknowledges their Ph.D. fellowships from FCT (Nos. SFRH/BD/ 109482/2015, SFRH/BD/109563/2015, and SFRH/BD/103507/2014).

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