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Nano Research 2019, 12(2): 247-264 https://doi.org/10.1007/s12274-018-2209-3
Review Article | Issue | Published: 15 October 2018

Graphene-based nanomaterials in biosystems

Show Author's Information Na Lu1,  Liqian Wang2,  Min Lv2,  Zisheng Tang3,4,5( ),  Chunhai Fan2,6( )
School of Materials Engineering,Shanghai University of Engineering Science,Shanghai,201620,China;
Division of Physical Biology and Bioimaging Center,Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences,Shanghai,201800,China;
Department of Endodontics,Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine,Shanghai,200011,China;
National Clinical Research Center of Oral Diseases,Shanghai,200011,China;
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology,Shanghai,200011,China;
School of Chemistry and Chemical Engineering,Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University,Shanghai,200240,China;
Keywords:
graphene-based nanomaterials, toxicology and biocompatibility, biomacromolecules, cells, living entities, applications
Topics:
BiocompatibilityBiological systemsCellsDrug deliveryNanostructured materialsPhysicochemical properties
Cite this article:
Lu N, Wang L, Lv M, et al. Graphene-based nanomaterials in biosystems. Nano Research, 2019, 12(2): 247-264. https://doi.org/10.1007/s12274-018-2209-3
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Abstract Full text About this article

Graphene-based nanomaterials have emerged as a novel type of materials with exceptional physicochemical properties and numerous applications in various areas. In this review, we summarize recent advances in studying interactions between graphene and biosystems. We first provide a brief introduction on graphene and its derivatives, and then discuss on the toxicology and biocompatibility of graphene, including the extracellular interactions between graphene and biomacromolecules, cellular studies of graphene, and in vivo toxicological effects. Next, we focus on various graphene-based practical applications in antibacterial materials, wound addressing, drug delivery, and water purification. We finally present perspectives on challenges and future developments in these exciting fields.


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About this article

Graphene-based nanomaterials in biosystems

Show Author's information Na Lu1, Liqian Wang2, Min Lv2, Zisheng Tang3,4,5( ), Chunhai Fan2,6( )
School of Materials Engineering,Shanghai University of Engineering Science,Shanghai,201620,China;
Division of Physical Biology and Bioimaging Center,Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences,Shanghai,201800,China;
Department of Endodontics,Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine,Shanghai,200011,China;
National Clinical Research Center of Oral Diseases,Shanghai,200011,China;
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology,Shanghai,200011,China;
School of Chemistry and Chemical Engineering,Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University,Shanghai,200240,China;

Abstract

Graphene-based nanomaterials have emerged as a novel type of materials with exceptional physicochemical properties and numerous applications in various areas. In this review, we summarize recent advances in studying interactions between graphene and biosystems. We first provide a brief introduction on graphene and its derivatives, and then discuss on the toxicology and biocompatibility of graphene, including the extracellular interactions between graphene and biomacromolecules, cellular studies of graphene, and in vivo toxicological effects. Next, we focus on various graphene-based practical applications in antibacterial materials, wound addressing, drug delivery, and water purification. We finally present perspectives on challenges and future developments in these exciting fields.

Keywords: graphene-based nanomaterials, toxicology and biocompatibility, biomacromolecules, cells, living entities, applications

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Publication history
Copyright
Acknowledgements

Publication history

Received: 12 June 2018
Revised: 12 September 2018
Accepted: 14 September 2018
Published: 15 October 2018
Issue date: February 2019

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Acknowledgements

Acknowledgements

This work was financially supported by the National Key Research and Development Program (No. 2016YFA0201200), the Shanghai Municipal Natural Science Foundation (No. 17ZR1412100), the Key Laboratory of Interfacial Physics and Technology, the Chinese Academy of Sciences (No. CASKL-IPT1603), the Talent Program of Shanghai University of Engineering Science, the Startup Foundation for Doctors of Shanghai University of Engineering Science, and the National Natural Science Foundation of China (Nos. 81870749, 21373260, 31470960 and 51375294).

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