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Nano Research 2018, 11(10): 5240-5257 https://doi.org/10.1007/s12274-018-2179-5
Review Article | Issue | Published: 03 September 2018

Cell-based drug delivery systems for biomedical applications

Show Author's Information Teng Li,  He Dong,  Can Zhang( ),  Ran Mo( )
State Key Laboratory of Natural MedicinesJiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Advanced Pharmaceuticals and BiomaterialsChina Pharmaceutical UniversityNanjing210009China
Keywords:
drug delivery, natural particulates, nanotechnology, bioinspired, biomedical application
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Li T, Dong H, Zhang C, et al. Cell-based drug delivery systems for biomedical applications. Nano Research, 2018, 11(10): 5240-5257. https://doi.org/10.1007/s12274-018-2179-5
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Abstract Full text About this article

Spurred by numerous achievements in nanoscience and nanotechnology, the evolution of nanoparticulate drug delivery systems (nano-DDSs) is in its rapid growth period and attracting considerable attention due to their unique advantages in biomedical applications. Natural particulates ranging from mammalian cells to bacteria possess their own distinctive delivery processes and mechanisms, which inspires more design and development of cell-based DDSs by integrating the innate functions of cells with the nanoscale characteristics of nanoparticles. In this review article, we focus on the recent advances in cell-based DDSs for site-specific delivery of therapeutics and enhanced treatment of diseases. The promise and perils of cell-based DDSs are also discussed.


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About this article

Cell-based drug delivery systems for biomedical applications

Show Author's information Teng Li, He Dong, Can Zhang( ), Ran Mo( )
State Key Laboratory of Natural MedicinesJiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Advanced Pharmaceuticals and BiomaterialsChina Pharmaceutical UniversityNanjing210009China

Abstract

Spurred by numerous achievements in nanoscience and nanotechnology, the evolution of nanoparticulate drug delivery systems (nano-DDSs) is in its rapid growth period and attracting considerable attention due to their unique advantages in biomedical applications. Natural particulates ranging from mammalian cells to bacteria possess their own distinctive delivery processes and mechanisms, which inspires more design and development of cell-based DDSs by integrating the innate functions of cells with the nanoscale characteristics of nanoparticles. In this review article, we focus on the recent advances in cell-based DDSs for site-specific delivery of therapeutics and enhanced treatment of diseases. The promise and perils of cell-based DDSs are also discussed.

Keywords: drug delivery, natural particulates, nanotechnology, bioinspired, biomedical application

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Publication history
Copyright
Acknowledgements

Publication history

Received: 14 May 2018
Revised: 13 August 2018
Accepted: 14 August 2018
Published: 03 September 2018
Issue date: October 2018

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Acknowledgements

Acknowledges

This work was supported by the National Natural Science Foundation of China (No. 81673381), the Natural Science Foundation of Jiangsu Province of China for Distinguished Young Scholars (No. BK20150029), the Program for Jiangsu Province Innovative Research Talents, and the Program for Jiangsu Province Innovative Research Team.

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