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Review Article

Current taxane formulations and emerging cabazitaxel delivery systems

Boyang Sun1,2, Robert M. Straubinger3, Jonathan F. Lovell1,2( )
Department of Biomedical EngineeringUniversity at BuffaloState University of New YorkBuffaloNY14260USA
Department of Chemical and Biological EngineeringUniversity at BuffaloState University of New YorkBuffaloNY14260USA
Department of Pharmaceutical SciencesUniversity at BuffaloState University of New YorkBuffaloNY14214USA
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Abstract

Cabazitaxel is a second-generation taxane with promising anti-tumor activity and is approved for treating hormone-refractory metastatic prostate cancer previously treated with docetaxel. Although first-generation taxanes (i.e. paclitaxel and docetaxel) have sparked broad interest in a variety of drug delivery vehicles, fewer have yet been developed for cabazitaxel. This review summarizes several clinical-stage approaches for taxane formulation and recent efforts to develop novel cabazitaxel delivery systems.

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Keywords

cabazitaxelJevtana® taxanesdrug delivery systemsnanocarriers

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Nano Research
Volume 11 Issue 10,
October 2018
Pages 5193-5218
DOI: 10.1007/s12274-018-2171-0

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Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

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Cite this article:
Sun B, Straubinger RM, Lovell JF. Current taxane formulations and emerging cabazitaxel delivery systems. Nano Research, 2018, 11(10): 5193-5218. https://doi.org/10.1007/s12274-018-2171-0
Part of a topical collection:
NR45 Awards in NanoBiotech, 2018

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Received: 23 May 2018
Revised: 09 August 2018
Accepted: 10 August 2018
Published: 30 August 2018
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018