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Nano Research 2018, 11(10): 5400-5423 https://doi.org/10.1007/s12274-018-2121-x
Review Article | Issue | Published: 21 June 2018

Temperature-responsive polymers: Synthesis, properties, and biomedical applications

Show Author's Information Shenglin Qiao1,2,  Hao Wang1,2( )
CAS Center for Excellence in NanoscienceCAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology (NCNST)Beijing100190China
University of Chinese Academy of Sciences (UCAS)Beijing100049China
Keywords:
nanomaterial, self-assembly, phase transition, nanomedicine, temperature-responsive polymer
Cite this article:
Qiao S, Wang H. Temperature-responsive polymers: Synthesis, properties, and biomedical applications. Nano Research, 2018, 11(10): 5400-5423. https://doi.org/10.1007/s12274-018-2121-x
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Abstract Full text About this article

Interest in temperature-responsive polymers has steadily grown over the past several decades, and numerous studies have been dedicated to developing temperature sensitive polymers that can be constructed into new smart materials for biomedical applications. Phase behavior of a temperature-responsive polymer plays a pivotal role in determining its biological performance in certain conditions. In addition to the additives (such as salts and proteins) in aqueous solutions, molecular weight, molecular weight distribution, and structural or compositional factors can also significantly affect the transition temperatures of the polymers. This review comprehensively describes well-established and newly developed synthetic strategies for preparing temperature-responsive polymers. The structural and compositional parameters that affect the transition temperatures and self-assembly behavior are discussed. Finally, the biomedical applications of the temperature-responsive polymers in drug delivery, immunotherapy, tissue engineering, and diagnosis are summarized.


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About this article

Temperature-responsive polymers: Synthesis, properties, and biomedical applications

Show Author's information Shenglin Qiao1,2, Hao Wang1,2( )
CAS Center for Excellence in NanoscienceCAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology (NCNST)Beijing100190China
University of Chinese Academy of Sciences (UCAS)Beijing100049China

Abstract

Interest in temperature-responsive polymers has steadily grown over the past several decades, and numerous studies have been dedicated to developing temperature sensitive polymers that can be constructed into new smart materials for biomedical applications. Phase behavior of a temperature-responsive polymer plays a pivotal role in determining its biological performance in certain conditions. In addition to the additives (such as salts and proteins) in aqueous solutions, molecular weight, molecular weight distribution, and structural or compositional factors can also significantly affect the transition temperatures of the polymers. This review comprehensively describes well-established and newly developed synthetic strategies for preparing temperature-responsive polymers. The structural and compositional parameters that affect the transition temperatures and self-assembly behavior are discussed. Finally, the biomedical applications of the temperature-responsive polymers in drug delivery, immunotherapy, tissue engineering, and diagnosis are summarized.

Keywords: nanomaterial, self-assembly, phase transition, nanomedicine, temperature-responsive polymer

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Publication history
Copyright
Acknowledgements

Publication history

Received: 10 May 2018
Revised: 30 May 2018
Accepted: 02 June 2018
Published: 21 June 2018
Issue date: October 2018

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 21374026 and 51573032), the National Science Fund for Distinguished Young Scholars (No. 51725302), Science Fund for Creative Research Groups of the National Natural Science Foundation of China (No. 11621505), CAS Key Research Program for Frontier Sciences (No. QYZDJ-SSW-SLH022), Key Project of Chinese Academy of Sciences in Cooperation with Foreign Enterprises (No. GJHZ1541), and CAS Interdisciplinary Innovation Team.

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