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Nano Research 2018, 11(10): 5670-5688 https://doi.org/10.1007/s12274-018-2104-y
Research Article | Issue | Published: 08 June 2018

Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with hypoxic-ischemic encephalopathy

Show Author's Information Andrea Joseph1,  Thomas Wood2,  Chih-Chung Chen1,†,  Kylie Corry2,  Jessica M. Snyder3,  Sandra E. Juul2,  Pratik Parikh2,  Elizabeth Nance1,4( )
Department of Chemical EngineeringUniversity of WashingtonSeattleWA98195USA
Division of NeonatologyDepartment of PediatricsUniversity of WashingtonSeattleWA98195USA
Department of Comparative MedicineUniversity of WashingtonSeattleWA98195USA
Department of RadiologyUniversity of WashingtonSeattleWA98195USA

† Present address: Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

Keywords:
drug delivery, curcumin, neuroprotection, brain penetrating, neonatal hypoxia-ischemia, nanotherapeutics
Cite this article:
Joseph A, Wood T, Chen C-C, et al. Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with hypoxic-ischemic encephalopathy. Nano Research, 2018, 11(10): 5670-5688. https://doi.org/10.1007/s12274-018-2104-y
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Abstract Full text About this article

Hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Inflammatory processes play a key role in the progression of this disease and may be amenable to a targeted pharmaceutical intervention. Curcumin is a dietary compound with potent anti-inflammatory, antioxidant, and antiapoptotic properties but is limited in therapeutic applications due to its low aqueous solubility, low bioavailability, and rapid first-pass hepatic metabolism. To address these limitations, loading curcumin into poly(lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-PEG) nanoparticles may increase relevant pharmacokinetic parameters and allow for effective drug delivery to the brain. Using the Vannucci model of unilateral hypoxic-ischemic brain injury in neonatal rats, we studied the in vivo effect of curcumin-loaded PLGA-PEG nanoparticles on brain uptake and diffusion of curcumin and on neuroprotection. The curcumin-loaded nanoparticles were able to overcome the impaired blood–brain barrier, diffuse effectively through the brain parenchyma, localize in regions of injury, and deliver a protective effect in the injured neonatal brain. The application of curcumin and PLGA-PEG nanoparticle-mediated delivery to a clinically relevant model of neonatal brain injury provides greater opportunities for clinical translation of targeted therapies for hypoxic-ischemic encephalopathy.


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About this article

Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with hypoxic-ischemic encephalopathy

Show Author's information Andrea Joseph1, Thomas Wood2, Chih-Chung Chen1,†, Kylie Corry2, Jessica M. Snyder3, Sandra E. Juul2, Pratik Parikh2, Elizabeth Nance1,4( )
Department of Chemical EngineeringUniversity of WashingtonSeattleWA98195USA
Division of NeonatologyDepartment of PediatricsUniversity of WashingtonSeattleWA98195USA
Department of Comparative MedicineUniversity of WashingtonSeattleWA98195USA
Department of RadiologyUniversity of WashingtonSeattleWA98195USA

† Present address: Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

Abstract

Hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Inflammatory processes play a key role in the progression of this disease and may be amenable to a targeted pharmaceutical intervention. Curcumin is a dietary compound with potent anti-inflammatory, antioxidant, and antiapoptotic properties but is limited in therapeutic applications due to its low aqueous solubility, low bioavailability, and rapid first-pass hepatic metabolism. To address these limitations, loading curcumin into poly(lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-PEG) nanoparticles may increase relevant pharmacokinetic parameters and allow for effective drug delivery to the brain. Using the Vannucci model of unilateral hypoxic-ischemic brain injury in neonatal rats, we studied the in vivo effect of curcumin-loaded PLGA-PEG nanoparticles on brain uptake and diffusion of curcumin and on neuroprotection. The curcumin-loaded nanoparticles were able to overcome the impaired blood–brain barrier, diffuse effectively through the brain parenchyma, localize in regions of injury, and deliver a protective effect in the injured neonatal brain. The application of curcumin and PLGA-PEG nanoparticle-mediated delivery to a clinically relevant model of neonatal brain injury provides greater opportunities for clinical translation of targeted therapies for hypoxic-ischemic encephalopathy.

Keywords: drug delivery, curcumin, neuroprotection, brain penetrating, neonatal hypoxia-ischemia, nanotherapeutics

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Publication history
Copyright
Acknowledgements

Publication history

Received: 15 March 2018
Revised: 15 May 2018
Accepted: 18 May 2018
Published: 08 June 2018
Issue date: October 2018

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Acknowledgements

Acknowledgements

This manuscript was supported by the Burroughs Wellcome Fund Career Award at Scientific Interfaces (E. N.) and the University of Washington Department of Pediatrics Neonatal Biology Research Grant (P. P.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Burroughs Wellcome Fund.

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