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Nano Research 2018, 11(10): 4955-4984 https://doi.org/10.1007/s12274-018-2092-y
Review Article | Issue | Published: 26 May 2018

Scavenging of reactive oxygen and nitrogen species with nanomaterials

Show Author's Information Carolina A. Ferreira,  Dalong Ni( ),  Zachary T. Rosenkrans,  Weibo Cai( )
Department of RadiologyUniversity of Wisconsin-MadisonMadisonWI53705USA
Keywords:
mnanomaterials, reactive oxygen species (ROS), reactive nitrogen species, ROS scavenging, antioxidant nanoparticles
Cite this article:
Ferreira CA, Ni D, Rosenkrans ZT, et al. Scavenging of reactive oxygen and nitrogen species with nanomaterials. Nano Research, 2018, 11(10): 4955-4984. https://doi.org/10.1007/s12274-018-2092-y
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Abstract Full text About this article

Reactive oxygen and nitrogen species (RONS) are essential for normal physiological processes and play important roles in cell signaling, immunity, and tissue homeostasis. However, excess radical species are implicated in the development and augmented pathogenesis of various diseases. Several antioxidants may restore the chemical balance, but their use is limited by disappointing results of clinical trials. Nanoparticles are an attractive therapeutic alternative because they can change the biodistribution profile of antioxidants, and possess intrinsic ability to scavenge RONS. Herein, we review the types of RONS, how they are implicated in several diseases, and the types of nanoparticles with inherent antioxidant capability, their mechanisms of action, and their biological applications.


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About this article

Scavenging of reactive oxygen and nitrogen species with nanomaterials

Show Author's information Carolina A. Ferreira, Dalong Ni( ), Zachary T. Rosenkrans, Weibo Cai( )
Department of RadiologyUniversity of Wisconsin-MadisonMadisonWI53705USA

Abstract

Reactive oxygen and nitrogen species (RONS) are essential for normal physiological processes and play important roles in cell signaling, immunity, and tissue homeostasis. However, excess radical species are implicated in the development and augmented pathogenesis of various diseases. Several antioxidants may restore the chemical balance, but their use is limited by disappointing results of clinical trials. Nanoparticles are an attractive therapeutic alternative because they can change the biodistribution profile of antioxidants, and possess intrinsic ability to scavenge RONS. Herein, we review the types of RONS, how they are implicated in several diseases, and the types of nanoparticles with inherent antioxidant capability, their mechanisms of action, and their biological applications.

Keywords: mnanomaterials, reactive oxygen species (ROS), reactive nitrogen species, ROS scavenging, antioxidant nanoparticles

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Publication history
Copyright
Acknowledgements

Publication history

Received: 14 March 2018
Revised: 01 May 2018
Accepted: 04 May 2018
Published: 26 May 2018
Issue date: October 2018

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Acknowledgements

Acknowledgements

This work was supported, in part, by the University of Wisconsin-Madison, the National Institutes of Health (No. NIBIB/NCI P30CA014520) and the Brazilian Science without Borders Program (No. SwB-CNPq).

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