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Nano Research 2018, 11(8): 4333-4347 https://doi.org/10.1007/s12274-018-2021-0
Research Article | Issue | Published: 16 March 2018

A chemophotothermal and targeting multifunctional nanoprobe with a tumor-diagnosing ability

Show Author's Information Niannian Li1,§,  Jiejun Cheng2,§,  Ying Zhang1,§,  Jie Wang1,  Gang Huang3( ),  Jun Zhu4( ),  Dannong He1,4( )
School of Materials Science and EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai200240China
Department of RadiologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China
Shanghai University of Medicine & Health Sciences279 Zhou Zhu highwayShanghai201318China
National Engineering Research Center for Nanotechnology28 East Jiang Chuan RoadShanghai200241China

§ Niannian Li, Jiejun Cheng and Ying Zhang contributed equally to this work.

Keywords:
gold nanorods, Mn doping, magnetic resonance or computed tomography (MR/CT) imaging, chemophotothermal therapy
Cite this article:
Li N, Cheng J, Zhang Y, et al. A chemophotothermal and targeting multifunctional nanoprobe with a tumor-diagnosing ability. Nano Research, 2018, 11(8): 4333-4347. https://doi.org/10.1007/s12274-018-2021-0
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Abstract Full text About this article

The development of multifunctional nanoparticles for diagnosis and therapy of cancer has been a focus of research in recent years. Owing to excellent properties of chemophotothermal therapy and tumor targeting accompanied by magnetic resonance (MR) or computed tomography (CT) imaging, mesoporous silica has been widely applied to tumor diagnosing carriers. However, previous research focused more on chemotherapy combined with photothermal therapeutic strategies but ignored intuitive assessment of tumors. In this work, we report a novel nanoprobe consisting of hyaluronic-acid–modified Gold Nanorods@mSiO2@Mn@DOX (GNR@MMH@DOX) nanoparticles, which realize multifunctional integration of therapeutics and imaging. Au nanorods (GNRs) were synthesized without a seed precursor by a water bath method, then sequentially modified with mesoporous silica, doped with Mn2+, and loaded with doxorubicin in a solution. In vitro and in vivo assays verified their great biocompatibility, good stability, and attractive specificity of targeting to receptor CD44, which is overexpressed on cancer cells. In addition, GNR@MMH nanoparticles proved to be a more distinguishable CT/MR imaging contrast compared to commercial contrast agents. The article demonstrates promising composition for CT/MR imaging and photothermal therapy of tumors, giving new insights into the diagnosis and therapy of different kinds of malignant tumors.


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About this article

A chemophotothermal and targeting multifunctional nanoprobe with a tumor-diagnosing ability

Show Author's information Niannian Li1,§, Jiejun Cheng2,§, Ying Zhang1,§, Jie Wang1, Gang Huang3( ), Jun Zhu4( ), Dannong He1,4( )
School of Materials Science and EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai200240China
Department of RadiologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China
Shanghai University of Medicine & Health Sciences279 Zhou Zhu highwayShanghai201318China
National Engineering Research Center for Nanotechnology28 East Jiang Chuan RoadShanghai200241China

§ Niannian Li, Jiejun Cheng and Ying Zhang contributed equally to this work.

Abstract

The development of multifunctional nanoparticles for diagnosis and therapy of cancer has been a focus of research in recent years. Owing to excellent properties of chemophotothermal therapy and tumor targeting accompanied by magnetic resonance (MR) or computed tomography (CT) imaging, mesoporous silica has been widely applied to tumor diagnosing carriers. However, previous research focused more on chemotherapy combined with photothermal therapeutic strategies but ignored intuitive assessment of tumors. In this work, we report a novel nanoprobe consisting of hyaluronic-acid–modified Gold Nanorods@mSiO2@Mn@DOX (GNR@MMH@DOX) nanoparticles, which realize multifunctional integration of therapeutics and imaging. Au nanorods (GNRs) were synthesized without a seed precursor by a water bath method, then sequentially modified with mesoporous silica, doped with Mn2+, and loaded with doxorubicin in a solution. In vitro and in vivo assays verified their great biocompatibility, good stability, and attractive specificity of targeting to receptor CD44, which is overexpressed on cancer cells. In addition, GNR@MMH nanoparticles proved to be a more distinguishable CT/MR imaging contrast compared to commercial contrast agents. The article demonstrates promising composition for CT/MR imaging and photothermal therapy of tumors, giving new insights into the diagnosis and therapy of different kinds of malignant tumors.

Keywords: gold nanorods, Mn doping, magnetic resonance or computed tomography (MR/CT) imaging, chemophotothermal therapy

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Publication history
Copyright
Acknowledgements

Publication history

Received: 07 November 2017
Revised: 05 February 2018
Accepted: 09 February 2018
Published: 16 March 2018
Issue date: August 2018

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Acknowledgements

Acknowledgements

The work is supported by Shanghai Science and Technology Development Funds (Nos. 17XD1421900, 14411968100 and 17XD1424200) and Seed Fund of Renji Hospital of Shanghai Jiao Tong University School of Medicine (No. RJZZ16-010).

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