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Nano Research 2018, 11(7): 3762-3770 https://doi.org/10.1007/s12274-017-1947-y
Research Article | Issue | Published: 02 August 2018

Phytochemical-encapsulated nanoplatform for "on-demand" synergistic treatment of multidrug-resistant bacteria

Show Author's Information Panpan Sun1,3,  Yan Zhang1,  Xiang Ran1,  Chaoying Liu2( ),  Zhenzhen Wang1,  Jinsong Ren1( ),  Xiaogang Qu1( )
State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical BiologyChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China
Department of Respiratory MedicineFirst Affiliated HospitalJilin UniversityChangchun130021China
University of Science and Technology of ChinaHefei230029China
Keywords:
nanocarriers, multidrug-resistant bacteria, on-demand, synergistic treatment
Cite this article:
Sun P, Zhang Y, Ran X, et al. Phytochemical-encapsulated nanoplatform for "on-demand" synergistic treatment of multidrug-resistant bacteria. Nano Research, 2018, 11(7): 3762-3770. https://doi.org/10.1007/s12274-017-1947-y
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Abstract Full text Electronic supplementary material About this article

Though phytochemicals are a promising alternative to traditional antibiotics for combating resistant bacteria, the low water solubility and lack of selectivity seriously hinder their widespread applications. Herein, we constructed a hyaluronidase-activated "on-demand" delivery nanocarrier to encapsulate plant essential oils (PEOs) for the synergistic treatment of multidrug-resistant bacteria. The bioavailability and selectivity of PEOs was enhanced and the antibacterial effect was significantly improved by combining with the photothermal effect of the nanocarrier. This antibacterial system was successfully applied for healing methicillin-resistant Staphylococcus aureus-infected wound with negligible cytotoxicity and biotoxicity in mice. Given the increasing risk of antibiotic resistance, we believe that this phytochemical-encapsulated nanoplatform would provide a long-term solution and be a new powerful tool for skin-associated bacterial infections.


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Electronic supplementary material
About this article

Phytochemical-encapsulated nanoplatform for "on-demand" synergistic treatment of multidrug-resistant bacteria

Show Author's information Panpan Sun1,3, Yan Zhang1, Xiang Ran1, Chaoying Liu2( ), Zhenzhen Wang1, Jinsong Ren1( ), Xiaogang Qu1( )
State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical BiologyChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China
Department of Respiratory MedicineFirst Affiliated HospitalJilin UniversityChangchun130021China
University of Science and Technology of ChinaHefei230029China

Abstract

Though phytochemicals are a promising alternative to traditional antibiotics for combating resistant bacteria, the low water solubility and lack of selectivity seriously hinder their widespread applications. Herein, we constructed a hyaluronidase-activated "on-demand" delivery nanocarrier to encapsulate plant essential oils (PEOs) for the synergistic treatment of multidrug-resistant bacteria. The bioavailability and selectivity of PEOs was enhanced and the antibacterial effect was significantly improved by combining with the photothermal effect of the nanocarrier. This antibacterial system was successfully applied for healing methicillin-resistant Staphylococcus aureus-infected wound with negligible cytotoxicity and biotoxicity in mice. Given the increasing risk of antibiotic resistance, we believe that this phytochemical-encapsulated nanoplatform would provide a long-term solution and be a new powerful tool for skin-associated bacterial infections.

Keywords: nanocarriers, multidrug-resistant bacteria, on-demand, synergistic treatment

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Publication history
Copyright
Acknowledgements

Publication history

Received: 09 October 2017
Revised: 29 November 2017
Accepted: 01 December 2017
Published: 02 August 2018
Issue date: July 2018

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2017

Acknowledgements

Acknowledgements

We acknowledge financial support from the National Natural Science Foundation of China (Nos. 21210002, 21431007, 21533008, 21403209, 21601175, and 21673223) and the Jilin Province Science and Technology Development Plan Project (No. 20140101039JC).

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