Mesoporous Mn-Sn bimetallic oxide (BO) nanocubes with sizes of 15-30 nm show outstanding stable and reversible capacities in lithium ion batteries (LIBs), reaching 856.8 mAh·g-1 after 400 cycles at 500 mA·g-1 and 506 mAh·g-1 after 850 cycles at 1, 000 mA·g-1. The preliminary investigation of the reaction mechanism, based on X-ray diffraction measurements, indicates the occurrence of both conversion and alloying-dealloying reactions in the Mn-Sn bimetallic oxide electrode. Moreover, Mn-Sn BO//LiCoO2 Li-ion full cells were successfully assembled for the first time, and found to deliver a relatively high energy density of 176.25 Wh·kg-1 at 16.35 W·kg-1 (based on the total weight of anode and cathode materials). The superior long-term stability of these materials might be attributed to their nanoscale size and unique mesoporous nanocubic structure, which provide short Li+ diffusion pathways and a high contact area between electrolyte and active material. In addition, the Mn-Sn BOs could be used as advanced sulfur hosts for lithium-sulfur batteries, owing to their adequate mesoporous structure and relatively strong chemisorption of lithium polysulfide. The present results thus highlight the promising potential of mesoporous Mn-Sn bimetallic oxides for application in Li-ion and Li-S batteries.