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Nano Research 2018, 11(5): 2796-2808 https://doi.org/10.1007/s12274-017-1910-y
Research Article | Issue | Published: 12 May 2018

Porous hollow palladium nanoplatform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy

Show Author's Information Menglin Song1,  Nian Liu1,  Le He3,  Gang Liu1,  Daishun Ling4,  Xinhui Su5,  Xiaolian Sun1,2( )
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen361005China
Department of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing210009China
Institute of Functional Nano & Soft Materials (FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow UniversitySuzhou215123China
Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China
Department of Nuclear MedicineZhongshan Hospital Xiamen UniversityXiamen361004China
Keywords:
photothermal therapy, chemotherapy, radiotherapy, porous hollow nanoparticles
Cite this article:
Song M, Liu N, He L, et al. Porous hollow palladium nanoplatform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy. Nano Research, 2018, 11(5): 2796-2808. https://doi.org/10.1007/s12274-017-1910-y
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Abstract Full text Electronic supplementary material About this article

Cancer is one of the major causes of human death. There are many types of cancer treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy. Combining different therapies can synergistically enhance the therapeutic effect. We developed porous hollow palladium nanoparticles (PHPdNPs) to co-deliver 131I (a radioisotope that is commonly used in radiotherapy) and doxorubicin (DOX; a chemotherapy drug). Compared with other mesoporous nanocarriers, our PHPdNPs exhibited impressive photothermal conversion efficiency and stability. Drug loading is high and drug release is controllable by repeated laser irradiation and acidic pH in tumor microenvironments. Owing to the specific interaction between palladium and iodine, the PHPdNPs serve as effective 131I delivery vehicles with excellent radiochemical stability. A single dose of [131I]PHPdNPs-DOX has superior antitumor efficacy because it enables a combination of chemo-, photothermal-, and radio-therapy. Moreover, the nanocomplex has no obvious side-effects in mice. Therefore, we believe that PHPdNPs are excellent candidates for multimodal imaging-guided therapy.


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About this article

Porous hollow palladium nanoplatform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy

Show Author's information Menglin Song1, Nian Liu1, Le He3, Gang Liu1, Daishun Ling4, Xinhui Su5, Xiaolian Sun1,2( )
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen361005China
Department of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing210009China
Institute of Functional Nano & Soft Materials (FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow UniversitySuzhou215123China
Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China
Department of Nuclear MedicineZhongshan Hospital Xiamen UniversityXiamen361004China

Abstract

Cancer is one of the major causes of human death. There are many types of cancer treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy. Combining different therapies can synergistically enhance the therapeutic effect. We developed porous hollow palladium nanoparticles (PHPdNPs) to co-deliver 131I (a radioisotope that is commonly used in radiotherapy) and doxorubicin (DOX; a chemotherapy drug). Compared with other mesoporous nanocarriers, our PHPdNPs exhibited impressive photothermal conversion efficiency and stability. Drug loading is high and drug release is controllable by repeated laser irradiation and acidic pH in tumor microenvironments. Owing to the specific interaction between palladium and iodine, the PHPdNPs serve as effective 131I delivery vehicles with excellent radiochemical stability. A single dose of [131I]PHPdNPs-DOX has superior antitumor efficacy because it enables a combination of chemo-, photothermal-, and radio-therapy. Moreover, the nanocomplex has no obvious side-effects in mice. Therefore, we believe that PHPdNPs are excellent candidates for multimodal imaging-guided therapy.

Keywords: photothermal therapy, chemotherapy, radiotherapy, porous hollow nanoparticles

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Publication history
Copyright
Acknowledgements

Publication history

Received: 10 September 2017
Revised: 03 November 2017
Accepted: 04 November 2017
Published: 12 May 2018
Issue date: May 2018

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2017

Acknowledgements

Acknowledgements

This research was supported in part by the National Key Research and Development Program of China (No. 2016YFA0203600), National Natural Science Foundation of China (Nos. 81571743, 51502251, and 81571707), Fundamental Research Funds for Xiamen University (No. 20720160067) and Natural Science Foundation of Fujian Province (Nos. 2015J01519 and 2014Y2004).

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