Coordination-responsive drug release inside gold nanorod@metal-organic framework core–shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy
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Multifunctional core–shell nanostructures formed by integration of distinct components have received wide attention as promising biological platforms in recent years. In this work, crystalline zeolitic imidazolate framework-8 (ZIF-8), a typical metal-organic framework (MOF), is coated onto single gold nanorod(AuNR) core for successful realization of synergistic photothermal and chemotherapy triggered by near-infrared (NIR) light. Impressively, high doxorubicin hydrochloride (DOX) loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented through formation and breakage of coordination bonds in the system. Moreover, under NIR laser irradiation at 808 nm, these novel AuNR@MOF core–shell nanostructures exhibit effective synergistic chemo-photothermal therapy both in vitro and in vivo, confirmed by cell treatment and tumor ablation via intravenous injection.
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Coordination-responsive drug release inside gold nanorod@metal-organic framework core–shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy
Abstract
Multifunctional core–shell nanostructures formed by integration of distinct components have received wide attention as promising biological platforms in recent years. In this work, crystalline zeolitic imidazolate framework-8 (ZIF-8), a typical metal-organic framework (MOF), is coated onto single gold nanorod(AuNR) core for successful realization of synergistic photothermal and chemotherapy triggered by near-infrared (NIR) light. Impressively, high doxorubicin hydrochloride (DOX) loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented through formation and breakage of coordination bonds in the system. Moreover, under NIR laser irradiation at 808 nm, these novel AuNR@MOF core–shell nanostructures exhibit effective synergistic chemo-photothermal therapy both in vitro and in vivo, confirmed by cell treatment and tumor ablation via intravenous injection.
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Acknowledgements
This work was supported financially by National Basic Research Program of China (Nos. 2014CB93-1801 and 2016YFA0200700, Z. Y. T.), National Natural Science Foundation for Distinguished Youth Scholars of China (No. 11425520, C. Y. C.), National Natural Science Foundation of China (Nos. 21721002, 21475029, and 91427302, Z. Y. T.; 21722301 and 21371038, Y. L. L.), Frontier Science Key Project of the Chinese Academy of Sciences (No. QYZDJ-SSW-SLH038, Z. Y. T.), CAS-CSIRO Cooperative Research Program (No. GJHZ1503, Z. Y. T.), "Strategic Priority Research Program" of Chinese Academy of Sciences (No. XDA09040100, Z. Y. T.; XDA09030308, Y. L. L.), Youth Innovation Promotion Association of Chinese Academy of Sciences (Y. L. L.), and K. C. Wong Education Foundation (Z. Y. T.).
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