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Silver nanoparticles (AgNPs) with distinct localized surface plasmon resonance (LSPR) absorption spectra can be synthesized using different proteins as templates upon irradiation by light. We utilized the multiple readouts of LSPR signals of AgNPs to construct sensor arrays for pattern recognition of proteins. Room temperature, aqueous solutions, and lack of harsh reducing reagents make the whole process inherently "green". Meanwhile, the strategy efficiently simplified the process of array-receptor preparation and data acquisition, leading to lower time consumption, sample use, and cost. Furthermore, the system can differentiate proteins using flexible and alterable sensor elements by choosing different combinations of LSPR signals at different wavelengths. The principle of the sensor design can also be further extended to differentiate other biomolecules. The study provides a new method to construct feasible, economical, and general nanoparticle-based sensing arrays for pattern recognition.

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Publication history
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Acknowledgements

Publication history

Received: 16 June 2017
Revised: 20 August 2017
Accepted: 22 August 2017
Published: 22 May 2018
Issue date: June 2018

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany 2017

Acknowledgements

Acknowledgements

Financial support was provided by the National Natural Science Foundation of China (Nos. 21210002, 21673223, 21431007, and 21533008), and the Youth Innovation Promotion Association CAS (No. 2014202).

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