Journal Home > Volume 10 , Issue 10
Nano Research 2017, 10(10): 3434-3446 https://doi.org/10.1007/s12274-017-1555-x
Research Article | Issue | Published: 25 May 2017

Multifunctional core/satellite polydopamine@Nd3+- sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy

Show Author's Information Xing Ding1,2,  Jianhua Liu2,3,  Dapeng Liu1,  Junqi Li1,  Fan Wang1,  Leijiao Li1,  Yinghui Wang1( ),  Shuyan Song1( ),  Hongjie Zhang1( )
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC) Chinese Academy of Sciences (CAS)Changchun 130022 China
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry Jilin UniversityChangchun 130012 China
Department of Radiology, the Second Hospital of Jilin University Changchun 130041 China
Keywords:
biocompatibility, photothermal therapy, Nd3+-sensitized upconver, sion nanoparticles, dual-modality imaging, multifunctional theranostic platform
Cite this article:
Ding X, Liu J, Liu D, et al. Multifunctional core/satellite polydopamine@Nd3+- sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy. Nano Research, 2017, 10(10): 3434-3446. https://doi.org/10.1007/s12274-017-1555-x
Download citation
EndNote(RIS)
BibTeX

503

Views

37

Downloads

Citations

67

Crossref

N/A

WoS

69

Scopus

15

CSCD

Abstract Full text Electronic supplementary material About this article

Significant attenuation and overheating, caused by the absorption of the excitation band (980 nm) in water, are the major obstacles in the in vivo application of lanthanide-doped upconversion nanoparticles (UCNPs). Therefore, appropriately- structured Nd3+-doped UCNPs with 808 nm excitation could be a promising alternative. Herein, we developed core–shell–shell structured Nd3+-sensitized UCNPs as imaging agents, and decorated them onto the surface of polydopamine (PDA) to construct a novel multifunctional core/satellite nanotheranostic (PDA@UCNPs) for in vivo imaging guidance photothermal therapy using single 808 nm laser irradiation. The core–shell–shell structured design enabled outstanding upconversion luminescence properties and strong X-ray attenuation, thereby making the nanocomposites potential candidates for excellent upconversion luminescence/computed tomography dual modal imaging. In addition, the PDA core not only provides high photothermal conversion efficiency and outstanding antitumor effect, but also endows the platform with robust biocompatibility owing to its natural features. Therefore, this multifunctional nanocomposite could be a promising theranostic in future oncotherapy, with high therapeutic effectiveness but low side effects. This study would stimulate interest in designing bio- application-compatible multifunctional nanocomposites, especially for cancer diagnosis and treatment in vivo.


menu
Abstract
Full text
Outline
Electronic supplementary material
About this article

Multifunctional core/satellite polydopamine@Nd3+- sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy

Show Author's information Xing Ding1,2, Jianhua Liu2,3, Dapeng Liu1, Junqi Li1, Fan Wang1, Leijiao Li1, Yinghui Wang1( ), Shuyan Song1( ), Hongjie Zhang1( )
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC) Chinese Academy of Sciences (CAS)Changchun 130022 China
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry Jilin UniversityChangchun 130012 China
Department of Radiology, the Second Hospital of Jilin University Changchun 130041 China

Abstract

Significant attenuation and overheating, caused by the absorption of the excitation band (980 nm) in water, are the major obstacles in the in vivo application of lanthanide-doped upconversion nanoparticles (UCNPs). Therefore, appropriately- structured Nd3+-doped UCNPs with 808 nm excitation could be a promising alternative. Herein, we developed core–shell–shell structured Nd3+-sensitized UCNPs as imaging agents, and decorated them onto the surface of polydopamine (PDA) to construct a novel multifunctional core/satellite nanotheranostic (PDA@UCNPs) for in vivo imaging guidance photothermal therapy using single 808 nm laser irradiation. The core–shell–shell structured design enabled outstanding upconversion luminescence properties and strong X-ray attenuation, thereby making the nanocomposites potential candidates for excellent upconversion luminescence/computed tomography dual modal imaging. In addition, the PDA core not only provides high photothermal conversion efficiency and outstanding antitumor effect, but also endows the platform with robust biocompatibility owing to its natural features. Therefore, this multifunctional nanocomposite could be a promising theranostic in future oncotherapy, with high therapeutic effectiveness but low side effects. This study would stimulate interest in designing bio- application-compatible multifunctional nanocomposites, especially for cancer diagnosis and treatment in vivo.

Keywords: biocompatibility, photothermal therapy, Nd3+-sensitized upconver, sion nanoparticles, dual-modality imaging, multifunctional theranostic platform

References(45)

1

Lal, S.; Clare, S. E.; Halas, N. J. Nanoshell-enabled photothermal cancer therapy: Impending clinical impact. Acc. Chem. Res. 2008, 41, 1842–1851.
DOI Google Scholar
2

Robinson, J. T.; Tabakman, S. M.; Liang, Y. Y.; Wang, H. L.; Casalongue, H. S.; Vinh, D.; Dai, H. J. Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J. Am. Chem. Soc. 2011, 133, 6825–6831.
DOI Google Scholar
3

Xia, Y. N.; Li, W. Y.; Cobley, C. M.; Chen, J. Y.; Xia, X. H.; Zhang, Q.; Yang, M. X.; Cho, E. C.; Brown, P. K. Gold nanocages: From synthesis to theranostic applications. Acc. Chem. Res. 2011, 44, 914–924.
DOI Google Scholar
4

Dykman, L.; Khlebtsov, N. Gold nanoparticles in biomedical applications: Recent advances and perspectives. Chem. Soc. Rev. 2012, 41, 2256–2282.
DOI Google Scholar
5

Boisselier, E.; Astruc, D. Gold nanoparticles in nanomedicine: Preparations, imaging, diagnostics, therapies and toxicity. Chem. Soc. Rev. 2009, 38, 1759–1782.
DOI Google Scholar
6

Ke, H. T.; Wang, J. R.; Dai, Z. F.; Jin, Y. S.; Qu, E. Z.; Xing, Z. W.; Guo, C. X.; Yue, X. L.; Liu, J. B. Gold-nanoshelled microcapsules: Atheranostic agent for ultrasound contrast imaging and photothermal therapy. Angew. Chem., Int. Ed. 2011, 50, 3017–3021.
DOI Google Scholar
7

Liu, H. Y.; Liu, T. L.; Wu, X. L.; Li, L. L.; Tan, L. F.; Chen, D.; Tang, F. Q. Targeting gold nanoshells on silica nanorattles: A drug cocktail to fight breast tumors via a single irradiation with near-infrared laser light. Adv. Mater. 2012, 24, 755–761.
DOI Google Scholar
8

Cheng, L.; Yang, K.; Li, Y. G.; Chen, J. H.; Wang, C.; Shao, M. W.; Lee, S.-T.; Liu, Z. Facile preparation of multifunctional upconversionnanoprobes for multimodal imaging and dual-targeted photothermal therapy. Angew. Chem., Int. Ed. 2011, 50, 7385–7390.
DOI Google Scholar
9

Tian, Q. W.; Tang, M. H.; Sun, Y. G.; Zou, R. J.; Chen, Z. G.; Zhu, M. F.; Yang, S. P.; Wang, J. L.; Wang, J. H.; Hu, J. Q. Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells. Adv. Funct. Mater. 2011, 23, 3542–3547.
DOI Google Scholar
10

Tian, Q. W.; Jiang, F. R.; Zou, R. J.; Liu, Q.; Chen, Z. G.; Zhu, M. F.; Yang, S. P.; Wang, J. L.; Wang, J. H.; Hu, J. Q. Hydrophilic Cu9S5 nanocrystals: A photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano 2011, 5, 9761–9771.
DOI Google Scholar
11

Yang, K.; Zhang, S.; Zhang, G. X.; Sun, X. M.; Lee, S.-T.; Liu, Z. Graphene in mice: Ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 2010, 10, 3318–3323.
DOI Google Scholar
12

Yang, K.; Feng, L. Z.; Shi, X. Z.; Liu, Z. Nano-graphene in biomedicine: Theranostic applications. Chem. Soc. Rev. 2013, 42, 530–547.
DOI Google Scholar
13

Li, C. X.; Bolisetty, S.; Chaitanya, K.; Adamcik, J.; Mezzenga, R. Tunable carbon nanotube/protein core-shell nanoparticles with NIR- and enzymatic-responsive cytotoxicity. Adv. Mater. 2013, 25, 1010–1015.
DOI Google Scholar
14

Huang, X. Q.; Tang, S. H.; Mu, X. L.; Dai, Y.; Chen, G. X.; Zhou, Z. Y.; Ruan, F. X.; Yang, Z. L.; Zheng, N. F. Freestanding palladium nanosheets with plasmonic and catalytic properties. Nat. Nanotechnol. 2011, 6, 28–32.
DOI Google Scholar
15

Tang, S. H.; Huang, X. Q.; Zheng, N. F. Silica coating improves the efficacy of Pd nanosheets for photothermal therapy of cancer cells using near infrared laser. Chem. Commun. 2011, 47, 3948–3950.
DOI Google Scholar
16

Yang, J.; Choi, J.; Bang, D.; Kim, E.; Lim, E.-K.; Park, H.; Suh, J.-S.; Lee, K.; Yoo, K.-H.; Kim, E.-K. et al. Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells. Angew. Chem., Int. Ed. 2011, 50, 441–444.
DOI Google Scholar
17

Liu, Y. L.; Ai, K. L.; Liu, J. H.; Deng, M.; He, Y. Y.; Lu, L. H. Dopamine-melanin colloidal nanospheres: An efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy. Adv. Mater. 2013, 25, 1353–1359.
DOI Google Scholar
18

Stritzker, J.; Kirscher, L.; Scadeng, M.; Deliolanis, N. C.; Morscher, S.; Symvoulidis, P.; Schaefer, K.; Zhang, Q.; Buckel, L.; Hess, M. et al. Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer. Proc. Natl. Acad. Sci. USA 2013, 110, 3316–3320.
DOI Google Scholar
19

Wang, F.; Banerjee, D.; Liu, Y. S.; Chen, X. Y.; Liu, X. G. Upconversion nanoparticles in biological labeling, imaging, and therapy. Analyst 2010, 135, 1839–1854.
DOI Google Scholar
20

Wang, G. F.; Peng, Q.; Li, Y. D. Lanthanide-doped nanocrystals: Synthesis, optical-magnetic properties, and applications. Acc. Chem. Res. 2011, 44, 322–332.
DOI Google Scholar
21

Deng, M. L.; Wang, L. Y. Unexpected luminescence enhancement of upconverting nanocrystals by cation exchange with well retained small particle size. Nano Res. 2014, 7, 782–793.
DOI Google Scholar
22

Liu, Y. S.; Tu, D. T.; Zhu, H. M.; Chen, X. Y. Lanthanide- doped luminescent nanoprobes: Controlled synthesis, optical spectroscopy, and bioapplications. Chem. Soc. Rev. 2013, 42, 6924–6958.
DOI Google Scholar
23

Gorris, H. H.; Wolfbeis, O. S. Photon-upconverting nano­particles for optical encoding and multiplexing of cells, biomolecules, and microspheres. Angew. Chem., Int. Ed. 2013, 52, 3584–3600.
DOI Google Scholar
24

Cheng, L.; Yang, K.; Zhang, S.; Shao, M. W.; Lee, S.; Liu, Z. Highly-sensitive multiplexed in vivo imaging using PEGylatedupconversion nanoparticles. Nano Res. 2010, 3, 722–732.
DOI Google Scholar
25

Cheng, L.; Wang, C.; Liu, Z. Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy. Nanoscale 2013, 5, 23–37.
DOI Google Scholar
26

Chen, G. Y.; Qiu, H. L.; Prasad, P. N.; Chen, X. Y. Upconversion nanoparticles: Design, nanochemistry, and applications in theranostics. Chem. Rev. 2014, 114, 5161–5214.
DOI Google Scholar
27

Sun, L. D.; Wang, Y. F.; Yan, C. H. Paradigms and challenges for bioapplication of rare earth upconversion luminescent nanoparticles: Small size and tunable emission/excitation spectra. Acc. Chem. Res. 2014, 47, 1001–1009.
DOI Google Scholar
28

Zhou, J.; Liu, Q.; Feng, W.; Sun, Y.; Li, F. Y. Upconversion luminescent materials: Advances and applications. Chem. Rev. 2015, 115, 395–465.
DOI Google Scholar
29

Chen, Y. Y.; Liu, S.; Hou, Z. Y.; Ma, P.; Yang, D. M.; Li, C. X.; Lin, J. Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo. Nano Res. 2015, 8, 1917–1931.
DOI Google Scholar
30

Ni, D. L.; Zhang, J. W.; Bu, W. B.; Zhang, C.; Yao, Z. W.; Xing, H. Y.; Wang, J.; Duan, F.; Liu, Y. Y.; Fan, W. P. et al. PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging. Biomaterials 2016, 76, 218–225.
DOI Google Scholar
31

Weissleder, R. A clearer vision for in vivo imaging. Nat. Biotechnol. 2001, 19, 316–317.
DOI Google Scholar
32

Byrnes, K. R.; Waynant, R. W.; Ilev, I. K.; Wu, X. J.; Barna, L.; Smith, K.; Heckert, R.; Gerst, H.; Anders, J. J. Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury. Lasers Surg. Med. 2005, 36, 171–185.
DOI Google Scholar
33

Zhan, Q. Q.; Qian, J.; Liang, H. J.; Somesfalean, G.; Wang, D.; He, S. L.; Zhang, Z. G.; Andersson-Engels, S. Using 915 nm laser excited Tm3+/Er3+/Ho3+-doped NaYbF4 upconversion nanoparticles for in vitro and deeper in vivo bioimaging without overheating irradiation. ACS Nano 2011, 5, 3744–3757.
DOI Google Scholar
34

Zou, W. Q.; Visser, C.; Maduro, J. A.; Pshenichnikov, M. S.; Hummelen, J. C. Broadband dye-sensitized upconversion of near-infrared light. Nat. Photonics 2012, 6, 560–564.
DOI Google Scholar
35

Shen, J.; Chen, G. Y.; Vu, A. M.; Fan, W.; Bilsel, O. S.; Chang, C. C.; Han, G. Engineering the upconversion nano­particle excitation wavelength: Cascade sensitization of tri- doped upconversion colloidal nanoparticles at 800 nm. Adv. Opt. Mater. 2013, 1, 644–650.
DOI Google Scholar
36

Wang, Y. F.; Liu, G. Y.; Sun, L. D.; Xiao, J. W.; Zhou, J. C.; Yan, C. H. Nd3+-sensitized upconversion nanophosphors: Efficient in vivobioimaging probes with minimized heating effect. ACS Nano 2013, 7, 7200–7206.
DOI Google Scholar
37

Xie, X. J.; Gao, N. Y.; Deng, R. R.; Sun, Q.; Xu, Q. H.; Liu, X. G. Mechanistic investigation of photon upconversion in Nd3+-sensitized core–shell nanoparticles. J. Am. Chem. Soc. 2013, 135, 12608–12611.
DOI Google Scholar
38

Wen, H. L.; Zhu, H.; Chen, X.; Hung, T. F.; Wang, B. L.; Zhu, G. Y.; Yu, S. F.; Wang, F. Upconverting near-infrared light through energy management in core–shell–shell nano­particles. Angew. Chem., Int. Ed. 2013, 52, 13419–13423.
DOI Google Scholar
39

Zhong, Y. T.; Tian, G.; Gu, Z. J.; Yang, Y. J.; Gu, L.; Zhao, Y. L.; Ma, Y.; Yao, J. N. Elimination of photon quenching by a transition layer to fabricate a quenching-shield sandwich structure for 800 nm excited upconversion luminescence of Nd3+-sensitized nanoparticles. Adv. Mater. 2014, 26, 2831–2837.
DOI Google Scholar
40

Chen, Y. Y.; Liu, B.; Deng, X. R.; Huang, S. S.; Hou, Z. Y.; Li, C. X.; Lin, J. Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment. Nanoscale 2015, 7, 8574–8583.
DOI Google Scholar
41

Wang, D.; Xue, B.; Kong, X. G.; Tu, L. P.; Liu, X. M.; Zhang, Y. L.; Chang, Y. L.; Luo, Y. S.; Zhao, H. Y.; Zhang, H. 808 nm driven Nd3+-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging. Nanoscale 2015, 7, 190–197.
DOI Google Scholar
42

Zou, X. M.; Liu, Y.; Zhu, X. J.; Chen, M.; Yao, L. M.; Feng, W.; Li, F. Y. An Nd3+-sensitized upconversion nanophosphor modified with a cyanine dye for the ratiometricupconversion luminescence bioimaging of hypochlorite. Nanoscale 2015, 7, 4105–4113.
DOI Google Scholar
43

Liu, B.; Chen, Y. Y.; Li, C. X.; He, F.; Hou, Z. Y.; Huang, S. S.; Zhu, H. M.; Chen, X. Y.; Lin, J. Poly(acrylic acid) modification of Nd3+-sensitized upconversion nanophosphors for highly efficient UCL imaging and pH-responsive drug delivery. Adv. Funct. Mater. 2015, 25, 4717–4729.
DOI Google Scholar
44

Wang, Y. H.; Wang, H. G.; Liu, D. P.; Song, S. Y.; Wang, X.; Zhang, H. J. Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy. Biomaterials 2013, 34, 7715–7724.
DOI Google Scholar
45

Wang, Y. H.; Song, S. Y.; Liu, J. H.; Liu, D. P.; Zhang, H. J. ZnO-functionalized upconvertingnanotheranostic agent: Multi- modality imaging-guided chemotherapy with on-demand drug release triggered by pH. Angew. Chem., Int. Ed. 2015, 54, 536–540.
Google Scholar
File
nr-10-10-3434_ESM.pdf (1.9 MB)
Publication history
Copyright
Acknowledgements

Publication history

Received: 24 August 2016
Revised: 18 October 2016
Accepted: 23 February 2017
Published: 25 May 2017
Issue date: October 2017

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2017

Acknowledgements

Acknowledgements

This work was supported by the financial aid from the National Natural Science Foundation of China (Nos. 51502284, 51372242, 51402286, 21521092, 21590794, and 21210001), the Hong Kong, Macao and Taiwan Science and Technology Cooperation Special Project of Ministry of Science and Technology of China (No. 2014DFT10310), the Program of Science and Technology Development Plan of Jilin Province of China (No. 20140201007GX), the National Basic Research Program of China (No. 2014CB643802), the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20030300) and the Jilin Province Youth Foundation (No. 20150520007JH).

Return