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Nano Research 2017, 10(9): 3124-3135 https://doi.org/10.1007/s12274-017-1530-6
Research Article | Issue | Published: 18 May 2017

Gram-scale synthesis of nanotherapeutic agents for CT/T1-weighted MRI bimodal imaging guided photothermal therapy

Show Author's Information Xianguang Ding1,  Xiaoxia Hao1,  Dongdong Fu1,  Mengxin Zhang1,  Tian Lan1,  Chunyan Li1,  Renjun Huang2,  Zhijun Zhang1,  Yonggang Li2,  Qiangbin Wang1,  Jiang Jiang1( )
i-Lab and Division of Nanobiomedicine, CAS Key Laboratory of Nano-Bio Interface, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123 China
Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006 China
Keywords:
mesoporous silica, polydopamine, mass production, multimodal imaging, theranostic
Cite this article:
Ding X, Hao X, Fu D, et al. Gram-scale synthesis of nanotherapeutic agents for CT/T1-weighted MRI bimodal imaging guided photothermal therapy. Nano Research, 2017, 10(9): 3124-3135. https://doi.org/10.1007/s12274-017-1530-6
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Abstract Full text Electronic supplementary material About this article

Theranostic nanomedicine, which uses both imaging and therapeutic components for simultaneous disease diagnosis and treatment, is expected to improve patient treatment safety and outcomes by offering a more personalized approach to medicine. However, the poor reproducibilities of nanomedicines synthesized for optimized bioavailability and their potential toxicity are impeding clinical development. Moreover, milligram-scale synthetic methods are often inconsistent when transferred to mass production. To address these challenges, a facile, room temperature, aqueous phase synthesis of nanotheranostic agents using clinically validated mesoporous silica and naturally derived polydopamine has been developed. Since the synthetic procedure is simple and robust, and requires only simple mixing under ambient conditions, excellent batch-to-batch consistency has been achieved. As a result, this process can be easily scaled-up to produce gram-scale batches with physicochemical parameters similar to those of materials synthesized in smaller batches. The resulting nanotheranostic agents exhibit efficient X-ray tomography and T1-weighted magnetic resonance image contrast enhancing abilities due to their chemically ligated, benign Bi3+ and Fe3+ ions. Furthermore, the inclusion of a polydopamine shell makes the nanoparticle surface easy to functionalize and renders these materials highly efficient as photothermal agents. These nanotheranostic agents are suitable for mass production and for potential applications in multimodal imaging-guided therapy in clinical settings.


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Abstract
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Electronic supplementary material
About this article

Gram-scale synthesis of nanotherapeutic agents for CT/T1-weighted MRI bimodal imaging guided photothermal therapy

Show Author's information Xianguang Ding1, Xiaoxia Hao1, Dongdong Fu1, Mengxin Zhang1, Tian Lan1, Chunyan Li1, Renjun Huang2, Zhijun Zhang1, Yonggang Li2, Qiangbin Wang1, Jiang Jiang1( )
i-Lab and Division of Nanobiomedicine, CAS Key Laboratory of Nano-Bio Interface, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123 China
Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006 China

Abstract

Theranostic nanomedicine, which uses both imaging and therapeutic components for simultaneous disease diagnosis and treatment, is expected to improve patient treatment safety and outcomes by offering a more personalized approach to medicine. However, the poor reproducibilities of nanomedicines synthesized for optimized bioavailability and their potential toxicity are impeding clinical development. Moreover, milligram-scale synthetic methods are often inconsistent when transferred to mass production. To address these challenges, a facile, room temperature, aqueous phase synthesis of nanotheranostic agents using clinically validated mesoporous silica and naturally derived polydopamine has been developed. Since the synthetic procedure is simple and robust, and requires only simple mixing under ambient conditions, excellent batch-to-batch consistency has been achieved. As a result, this process can be easily scaled-up to produce gram-scale batches with physicochemical parameters similar to those of materials synthesized in smaller batches. The resulting nanotheranostic agents exhibit efficient X-ray tomography and T1-weighted magnetic resonance image contrast enhancing abilities due to their chemically ligated, benign Bi3+ and Fe3+ ions. Furthermore, the inclusion of a polydopamine shell makes the nanoparticle surface easy to functionalize and renders these materials highly efficient as photothermal agents. These nanotheranostic agents are suitable for mass production and for potential applications in multimodal imaging-guided therapy in clinical settings.

Keywords: mesoporous silica, polydopamine, mass production, multimodal imaging, theranostic

References(65)

1

Janib, S. M.; Moses, A. S.; MacKay, J. A. Imaging and drug delivery using theranostic nanoparticles. Adv. Drug Deliv. Rev. 2010, 62, 1052–1063.
DOI Google Scholar
2

MacKay, J. A.; Li, Z. B. Theranostic agents that co-deliver therapeutic and imaging agents? Adv. Drug Deliv. Rev. 2010, 62, 1003–1004.
DOI Google Scholar
3

Chen, X. Y.; Gambhir, S. S.; Cheon, J. Theranostic nano­medicine. Acc. Chem. Res. 2011, 44, 841–841.
DOI Google Scholar
4

Cheng, L.; Yang, K.; Li, Y. G.; Chen, J. H.; Wang, C.; Shao, M. W.; Lee, S.-T.; Liu, Z. Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dual-targeted photothermal therapy. Angew. Chem., Int. Ed. 2011, 50, 7385–7390.
DOI Google Scholar
5

Deng, H.; Dai, F. Y.; Ma, G. H.; Zhang, X. Theranostic gold nanomicelles made from biocompatible comb-like polymers for thermochemotherapy and multifunctional imaging with rapid clearance. Adv. Mater. 2015, 27, 3645–3653.
DOI Google Scholar
6

McQuade, C.; Al Zaki, A.; Desai, Y.; Vido, M.; Sakhuja, T.; Cheng, Z. L.; Hickey, R. J.; Joh, D.; Park, S.-J.; Kao, G. et al. A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response. Small 2015, 11, 834–843.
DOI Google Scholar
7

Tian, Q. W.; Hu, J. Q.; Zhu, Y. H.; Zou, R. J.; Chen, Z. G.; Yang, S. P.; Li, R. W.; Su, Q. Q.; Han, Y.; Liu, X. G. Sub-10 nm Fe3O4@Cu2−xS core–shell nanoparticles for dual-modal imaging and photothermal therapy. J. Am. Chem. Soc. 2013, 135, 8571–8577.
DOI Google Scholar
8

Fan, Q. L.; Cheng, K.; Hu, X.; Ma, X. W.; Zhang, R. P.; Yang, M.; Lu, X. M.; Xing, L.; Huang, W.; Gambhir, S. S., et al. Transferring biomarker into molecular probe: Melanin nanoparticle as a naturally active platform for multimodality imaging. J. Am. Chem. Soc. 2014, 136, 15185–15194.
DOI Google Scholar
9

Xiao, Q. F.; Zheng, X. P.; Bu, W. B.; Ge, W. Q.; Zhang, S. J.; Chen, F.; Xing, H. Y.; Ren, Q. G.; Fan, W. P.; Zhao, K. L. et al. A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/ photothermal synergistic therapy. J. Am. Chem. Soc. 2013, 135, 13041–13048.
DOI Google Scholar
10

Wang, Y.; Gu, H. C. Core–shell-type magnetic mesoporous silica nanocomposites for bioimaging and therapeutic agent delivery. Adv. Mater. 2015, 27, 576–585.
DOI Google Scholar
11

Yildirimer, L.; Thanh, N. T. K.; Loizidou, M.; Seifalian, A. M. Toxicology and clinical potential of nanoparticles. Nano Today 2011, 6, 585–607.
DOI Google Scholar
12

Kirsh, R.; Hood, S.; Brook, C.; Gilmartin, A.; Dell'orco, P.; Meek, T. Will nanomedicine deliver on its promise of changing therapeutics or remain an interesting and important research tool in cell biology and physiology? Int. J. Pharm. 2013, 454, 530–531.
DOI Google Scholar
13

Venditto, V. J.; Szoka, F. C., Jr. Cancer nanomedicines: So many papers and so few drugs! Adv. Drug Deliv. Rev. 2013, 65, 80–88.
DOI Google Scholar
14

Holzapfel, B. M.; Reichert, J. C.; Schantz, J.-T.; Gbureck, U.; Rackwitz, L.; Nöth, U.; Jakob, F.; Rudert, M.; Groll, J.; Hutmacher, D. W. How smart do biomaterials need to be? A translational science and clinical point of view. Adv. Drug Deliv. Rev. 2013, 65, 581–603.
DOI Google Scholar
15

Bazile, D. V. Nanotechnologies in drug delivery—An industrial perspective. J. Drug Deliv. Sci. Technol. 2014, 24, 12–21.
DOI Google Scholar
16

Min, Y. Z.; Caster, J. M.; Eblan, M. J.; Wang, A. Z. Clinical translation of nanomedicine. Chem. Rev. 2015, 115, 11147–11190.
DOI Google Scholar
17

Wei, A.; Mehtala, J. G.; Patri, A. K. Challenges and opportunities in the advancement of nanomedicines. J. Controlled Release 2012, 164, 236–246.
DOI Google Scholar
18

Marre, S.; Jensen, K. F. Synthesis of micro and nano­structures in microfluidic systems. Chem. Soc. Rev. 2010, 39, 1183–1202.
DOI Google Scholar
19

Valencia, P. M.; Farokhzad, O. C.; Karnik, R.; Langer, R. Microfluidic technologies for accelerating the clinical translation of nanoparticles. Nat. Nanotechnol. 2012, 7, 623–629.
DOI Google Scholar
20

Zhang, L.; Xia, Y. N. Scaling up the production of colloidal nanocrystals: Should we increase or decrease the reaction volume? Adv. Mater. 2014, 26, 2600–2606.
DOI Google Scholar
21

Naahidi, S.; Jafari, M.; Edalat, F.; Raymond, K.; Khademhosseini, A.; Chen, P. Biocompatibility of engineered nanoparticles for drug delivery. J. Controlled Release 2013, 166, 182–194.
DOI Google Scholar
22

Winnik, F. M.; Maysinger, D. Quantum dot cytotoxicity and ways to reduce it. Acc. Chem. Res. 2013, 46, 672–680.
DOI Google Scholar
23

Cheng, Z. L.; Al Zaki, A.; Hui, J. Z.; Muzykantov, V. R.; Tsourkas, A. Multifunctional nanoparticles: Cost versus benefit of adding targeting and imaging capabilities. Science 2012, 338, 903–910.
DOI Google Scholar
24

Li, C. A targeted approach to cancer imaging and therapy. Nat. Mater. 2014, 13, 110–115.
DOI Google Scholar
25

Tang, L.; Cheng, J. J. Nonporous silica nanoparticles for nanomedicine application. Nano Today 2013, 8, 290–312.
DOI Google Scholar
26

Yang, P. P.; Gai, S. L.; Lin, J. Functionalized mesoporous silica materials for controlled drug delivery. Chem. Soc. Rev. 2012, 41, 3679–3698.
DOI Google Scholar
27

Slowing, I. I.; Vivero-Escoto, J. L.; Wu, C.-W.; Lin, V. S. Y. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv. Drug Deliv. Rev. 2008, 60, 1278–1288.
DOI Google Scholar
28

Mamaeva, V.; Sahlgren, C.; Lindén, M. Mesoporous silica nanoparticles in medicine—Recent advances. Adv. Drug Deliv. Rev. 2013, 65, 689–702.
DOI Google Scholar
29

Yang, S.; Chen, D. Y.; Li, N. J.; Xu, Q. F.; Li, H.; Gu, F.; Xie, J. P.; Lu, J. M. Hollow mesoporous silica nanocarriers with multifunctional capping agents for in vivo cancer imaging and therapy. Small 2016, 12, 360–370.
DOI Google Scholar
30

Chiang, Y.-D.; Lian, H.-Y.; Leo, S.-Y.; Wang, S.-G.; Yamauchi, Y.; Wu, K. C. W. Controlling particle size and structural properties of mesoporous silica nanoparticles using the taguchi method. J. Phys. Chem. C 2011, 115, 13158–13165.
DOI Google Scholar
31

Malgras, V.; Ji, Q. M.; Kamachi, Y.; Mori, T.; Shieh, F.-K.; Wu, K. C. W.; Ariga, K.; Yamauchi, Y. Templated synthesis for nanoarchitectured porous materials. Bull. Chem. Soc. Jpn. 2015, 88, 1171–1200.
DOI Google Scholar
32

Wu, K. C. W.; Yamauchi, Y. Controlling physical features of mesoporous silica nanoparticles (MSNs) for emerging applications. J. Mater. Chem. 2012, 22, 1251–1256.
DOI Google Scholar
33

Yang, G. B.; Gong, H.; Qian, X. X.; Tan, P. L.; Li, Z. W.; Liu, T.; Liu, J. J.; Li, Y. Y.; Liu, Z. Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer. Nano Res. 2015, 8, 751–764.
DOI Google Scholar
34

Liu, T.; Wu, G. Y.; Cheng, J. J.; Lu, Q.; Yao, Y. J.; Liu, Z. J.; Zhu, D. C.; Zhou, J.; Xu, J. R.; Zhu, J. et al. Multifunctional lymph-targeted platform based on Mn@mSiO2 nanocom­posites: Combining PFOB for dual-mode imaging and DOX for cancer diagnose and treatment. Nano Res. 2016, 9, 473–489.
DOI Google Scholar
35

Chen, Y.; Chen, H. R.; Shi, J. L. In vivo bio-safety evaluations and diagnostic/therapeutic applications of chemically designed mesoporous silica nanoparticles. Adv. Mater. 2013, 25, 3144–3176.
DOI Google Scholar
36

Ambrogio, M. W.; Thomas, C. R.; Zhao, Y.-L.; Zink, J. I.; Stoddart, J. F. Mechanized silica nanoparticles: A new frontier in theranostic nanomedicine. Acc. Chem. Res. 2011, 44, 903–913.
DOI Google Scholar
37

Tang, F. Q.; Li, L. L.; Chen, D. Mesoporous silica nano­particles: Synthesis, biocompatibility and drug delivery. Adv. Mater. 2012, 24, 1504–1534.
DOI Google Scholar
38

Benezra, M.; Penate-Medina, O.; Zanzonico, P. B.; Schaer, D.; Ow, H.; Burns, A.; DeStanchina, E.; Longo, V.; Herz, E.; Iyer, S. et al. Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma. J. Clin. Invest. 2011, 121, 2768–2780.
DOI Google Scholar
39

Lee, H.; Dellatore, S. M.; Miller, W. M.; Messersmith, P. B. Mussel-inspired surface chemistry for multifunctional coatings. Science 2007, 318, 426–430.
DOI Google Scholar
40

Xu, C. J.; Xu, K. M.; Gu, H. W.; Zheng, R. K.; Liu, H.; Zhang, X. X.; Guo, Z. H.; Xu, B. Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. J. Am. Chem. Soc. 2004, 126, 9938–9939.
DOI Google Scholar
41

Hong, S.; Kim, K. Y.; Wook, H. J.; Park, S. Y.; Lee, K. D.; Lee, D. Y.; Lee, H. Attenuation of the in vivo toxicity of biomaterials by polydopamine surface modification. Nano­medicine 2011, 6, 793–801.
DOI Google Scholar
42

Lee, H.; Rho, J.; Messersmith, P. B. Facile conjugation of biomolecules onto surfaces via mussel adhesive protein inspired coatings. Adv. Mater. 2009, 21, 431–434.
DOI Google Scholar
43

Ju, K.-Y.; Lee, J. W.; Im, G. H.; Lee, S.; Pyo, J.; Park, S. B.; Lee, J. H.; Lee, J.-K. Bio-inspired, melanin-like nano­particles as a highly efficient contrast agent for T1-weighted magnetic resonance imaging. Biomacromolecules 2013, 14, 3491–3497.
DOI Google Scholar
44

Miao, Z.-H.; Wang, H.; Yang, H. J.; Li, Z.-L.; Zhen, L.; Xu, C.-Y. Intrinsically Mn2+-chelated polydopamine nano­particles for simultaneous magnetic resonance imaging and photothermal ablation of cancer cells. ACS Appl. Mater. Interfaces 2015, 7, 16946–16952.
DOI Google Scholar
45

Liu, Y. L.; Ai, K. L.; Liu, J. H.; Deng, M.; He, Y. Y.; Lu, L. H. Dopamine-melanin colloidal nanospheres: An efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy. Adv. Mater. 2013, 25, 1353–1359.
DOI Google Scholar
46

Lin, L.-S.; Cong, Z.-X.; Cao, J.-B.; Ke, K.-M.; Peng, Q.-L.; Gao, J. H.; Yang, H.-H.; Liu, G.; Chen, X. Y. Multifunctional Fe3O4@polydopamine core–shell nanocomposites for intra­cellular mRNA detection and imaging-guided photothermal therapy. ACS Nano 2014, 8, 3876–3883.
DOI Google Scholar
47

Zheng, Q. S.; Lin, T. R.; Wu, H. Y.; Guo, L. Q.; Ye, P. R.; Hao, Y. L.; Guo, Q. Q.; Jiang, J. Z.; Fu, F. F.; Chen, G. N. Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release. Int. J. Pharm. 2014, 463, 22–26.
DOI Google Scholar
48

Chang, D. F.; Gao, Y. F.; Wang, L. J.; Liu, G.; Chen, Y. H.; Wang, T.; Tao, W.; Mei, L.; Huang, L. Q.; Zeng, X. W. Polydopamine-based surface modification of mesoporous silica nanoparticles as pH-sensitive drug delivery vehicles for cancer therapy. J. Colloid Interface Sci. 2016, 463, 279–287.
DOI Google Scholar
49

Ai, K. L.; Liu, Y. L.; Liu, J. H.; Yuan, Q. H.; He, Y. Y.; Lu, L. H. Large-scale synthesis of Bi2S3 nanodots as a contrast agent for in vivo X-ray computed tomography imaging. Adv. Mater. 2011, 23, 4886–4891.
DOI Google Scholar
50

Brown, A. L.; Naha, P. C.; Benavides-Montes, V.; Litt, H. I.; Goforth, A. M.; Cormode, D. P. Synthesis, X-ray opacity, and biological compatibility of ultra-high payload elemental bismuth nanoparticle X-ray contrast agents. Chem. Mater. 2014, 26, 2266–2274.
DOI Google Scholar
51

Rabin, O.; Manuel Perez, J.; Grimm, J.; Wojtkiewicz, G.; Weissleder, R. An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat. Mater. 2006, 5, 118–122.
DOI Google Scholar
52

Wang, S. G.; Li, X.; Chen, Y.; Cai, X. J.; Yao, H. L.; Gao, W.; Zheng, Y. Y.; An, X.; Shi, J. L.; Chen, H. R. A facile one-pot synthesis of a two-dimensional MoS2/Bi2S3 composite theranostic nanosystem for multi-modality tumor imaging and therapy. Adv. Mater. 2015, 27, 2775–2782.
DOI Google Scholar
53

Liu, J.; Zheng, X. P.; Yan, L.; Zhou, L. J.; Tian, G.; Yin, W. Y.; Wang, L. M.; Liu, Y.; Hu, Z. B.; Gu, Z. J. et al. Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor. ACS Nano 2015, 9, 696–707.
DOI Google Scholar
54

Lee, N.; Choi, S. H.; Hyeon, T. Nano-sized CT contrast agents. Adv. Mater. 2013, 25, 2641–2660.
DOI Google Scholar
55

Peng, Y.-K.; Liu, C.-L.; Chen, H.-C.; Chou, S.-W.; Tseng, W.-H.; Tseng, Y.-J.; Kang, C.-C.; Hsiao, J.-K.; Chou, P.-T. Antiferromagnetic iron nanocolloids: A new generation in vivo T1 MRI contrast agent. J. Am. Chem. Soc. 2013, 135, 18621–18628.
DOI Google Scholar
56

Yang, Z. Z.; Ding, X. G.; Jiang, J. Facile synthesis of magnetic–plasmonic nanocomposites as T1 MRI contrast enhancing and photothermal therapeutic agents. Nano Res. 2016, 9, 787–799.
DOI Google Scholar
57

Tsai, M.-F.; Chang, S.-H. G.; Cheng, F.-Y.; Shanmugam, V.; Cheng, Y.-S.; Su, C.-H.; Yeh, C.-S. Au nanorod design as light-absorber in the first and second biological near-infrared windows for in vivo photothermal therapy. ACS Nano 2013, 7, 5330–5342.
DOI Google Scholar
58

Ding, X. G.; Liow, C. H.; Zhang, M. X.; Huang, R. J.; Li, C. Y.; Shen, H.; Liu, M. Y.; Zou, Y.; Gao, N.; Zhang, Z. J. et al. Surface plasmon resonance enhanced light absorption and photothermal therapy in the second near-infrared window. J. Am. Chem. Soc. 2014, 136, 15684–15693.
DOI Google Scholar
59

Park, J.; Brust, T. F.; Lee, H. J.; Lee, S. C.; Watts, V. J.; Yeo, Y. Polydopamine-based simple and versatile surface modification of polymeric nano drug carriers. ACS Nano 2014, 8, 3347–3356.
DOI Google Scholar
60

Desgrosellier, J. S.; Cheresh, D. A. Integrins in cancer: Biological implications and therapeutic opportunities. Nat. Rev. Cancer 2010, 10, 9–22.
DOI Google Scholar
61
Rüegg, C.; Alghisi, G. C. Vascular integrins: Therapeutic and imaging targets of tumor angiogenesis. In Angiogenesis Inhibition. Liersch, R.; Berdel, W. E.; Kessler, T., Eds.; Springer: Berlin Heidelberg, 2010; pp 83–101.https://doi.org/10.1007/978-3-540-78281-0_6
DOI
62

Miura, Y.; Takenaka, T.; Toh, K.; Wu, S.; Nishihara, H.; Kano, M. R.; Ino, Y.; Nomoto, T.; Matsumoto, Y.; Koyama, H. et al. Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood–brain tumor barrier. ACS Nano 2013, 7, 8583–8592.
DOI Google Scholar
63

Dane, K. Y.; Gottstein, C.; Daugherty, P. S. Cell surface profiling with peptide libraries yields ligand arrays that classify breast tumor subtypes. Mol. Cancer Ther. 2009, 8, 1312–1318.
DOI Google Scholar
64

Bangari, D. S.; Mittal, S. K. Porcine adenovirus serotype 3 internalization is independent of CAR and αvβ3 or αvβ5 integrin. Virology 2005, 332, 157–166.
DOI Google Scholar
65

Danhier, F.; Le Breton, A.; Préat, V. RGD-based strategies to target Alpha(v)Beta(3) integrin in cancer therapy and diagnosis. Mol. Pharmaceutics 2012, 9, 2961–2973.
DOI Google Scholar
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Publication history
Copyright
Acknowledgements

Publication history

Received: 06 September 2016
Revised: 26 January 2017
Accepted: 11 February 2017
Published: 18 May 2017
Issue date: September 2017

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2017

Acknowledgements

Acknowledgements

This work was funded by the National Natural Science Foundation of China (No. 21473243).

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