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Nano Research 2017, 10(8): 2633-2643 https://doi.org/10.1007/s12274-017-1466-x
Research Article | Issue | Published: 05 April 2017

Intercalated 2D nanoclay for emerging drug delivery in cancer therapy

Show Author's Information Yi Zhang1,§,  Mei Long1,§,  Peng Huang2,§,  Huaming Yang1,3( ),  Shi Chang2( ),  Yuehua Hu1,3( ),  Aidong Tang4,  Linfeng Mao2
Department of Inorganic Materials School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083 China
Xiangya Hospital Central South UniversityChangsha 410078 China
Hunan Key Laboratory of Mineral Materials and Application Central South UniversityChangsha 410083 China
School of Chemistry and Chemical Engineering Central South UniversityChangsha 410083 China

§ These authors contributed equally to this work.

Keywords:
drug delivery, biocompatibility, intercalation, cancer therapy, nanoclay
Cite this article:
Zhang Y, Long M, Huang P, et al. Intercalated 2D nanoclay for emerging drug delivery in cancer therapy. Nano Research, 2017, 10(8): 2633-2643. https://doi.org/10.1007/s12274-017-1466-x
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Abstract Full text Electronic supplementary material About this article

Natural two-dimensional (2D) kaolinite nanoclay has been incorporated into an emerging drug delivery system. The basal spacing of the kaolinite nanoclay was expanded from 0.72 to 4.16 nm through the intercalation of various organic guest species of different chain lengths, which can increase the efficiency in drug delivery and reduce the toxicity of doxorubicin (DOX). Original kaolinite (Kaolin) and the Kaolin intercalation compounds exhibited a high level of biocompatibility and very low toxicity towards cells of pancreatic cancer, gastric cancer, prostate cancer, breast cancer, colorectal cancer, esophageal cancer, and differentiated thyroid cancer. However, lung cancer and hepatocellular cancer cells need more strict compositional, structural, and morphological modulations for drug delivery carriers. DOX-Kaolin and the DOX-Kaolin intercalation compounds showed dramatically faster drug release in moderately acidic solution than in neutral condition, and exhibited enhanced therapeutic effects against ten model cancer cell cultures in a dose-dependent manner. The use of 2D nanoclay materials for a novel drug delivery system could feasibly pave a way towards high-performance nanotherapeutics, with superior antitumor efficacy and significantly reduced side effects.


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Abstract
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Electronic supplementary material
About this article

Intercalated 2D nanoclay for emerging drug delivery in cancer therapy

Show Author's information Yi Zhang1,§, Mei Long1,§, Peng Huang2,§, Huaming Yang1,3( ), Shi Chang2( ), Yuehua Hu1,3( ), Aidong Tang4, Linfeng Mao2
Department of Inorganic Materials School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083 China
Xiangya Hospital Central South UniversityChangsha 410078 China
Hunan Key Laboratory of Mineral Materials and Application Central South UniversityChangsha 410083 China
School of Chemistry and Chemical Engineering Central South UniversityChangsha 410083 China

§ These authors contributed equally to this work.

Abstract

Natural two-dimensional (2D) kaolinite nanoclay has been incorporated into an emerging drug delivery system. The basal spacing of the kaolinite nanoclay was expanded from 0.72 to 4.16 nm through the intercalation of various organic guest species of different chain lengths, which can increase the efficiency in drug delivery and reduce the toxicity of doxorubicin (DOX). Original kaolinite (Kaolin) and the Kaolin intercalation compounds exhibited a high level of biocompatibility and very low toxicity towards cells of pancreatic cancer, gastric cancer, prostate cancer, breast cancer, colorectal cancer, esophageal cancer, and differentiated thyroid cancer. However, lung cancer and hepatocellular cancer cells need more strict compositional, structural, and morphological modulations for drug delivery carriers. DOX-Kaolin and the DOX-Kaolin intercalation compounds showed dramatically faster drug release in moderately acidic solution than in neutral condition, and exhibited enhanced therapeutic effects against ten model cancer cell cultures in a dose-dependent manner. The use of 2D nanoclay materials for a novel drug delivery system could feasibly pave a way towards high-performance nanotherapeutics, with superior antitumor efficacy and significantly reduced side effects.

Keywords: drug delivery, biocompatibility, intercalation, cancer therapy, nanoclay

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Publication history
Copyright
Acknowledgements

Publication history

Received: 09 October 2016
Revised: 25 December 2016
Accepted: 30 December 2016
Published: 05 April 2017
Issue date: August 2017

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2017

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 51225403 and 41572036), the Hunan Provincial Science and Technology Project (Nos. 2016RS2004 and 2015TP1006), the Postdoctoral Science Foundation of Central South University (No. 155219) and the China Postdoctoral Science Foundation (No. 2015M582346).

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