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Large-area deep-silver-nanowell arrays (d-AgNWAs) for plasmonic sensing were manufactured by combining colloidal lithography with metal deposition. In contrast to most previous studies, we shed light on the outstanding sensitivity afforded by deep metallic nanowells (up to 400 nm in depth). Using gold nanohole arrays as a mask, a silicon substrate was etched into deep silicon nanowells, which acted as a template for subsequent Ag deposition, resulting in the formation of d-AgNWAs. Various geometric parameters were separately tailored to study the changes in the optical performance and further optimize the sensing ability of the structure. After several rounds of selection, the best sensing d-AgNWA, which had a Ag thickness of 400 nm, template depth of 400 nm, hole diameter of 504 nm, and period of 1 μm, was selected. It had a sensitivity of 933 nm·RIU–1, which is substantially higher than those of most common thin metallic nanohole arrays. As a proof of concept, the as-prepared structure was employed as a substrate for an antigen-antibody recognition immunoassay, which indicates its great potential for label-free real-time biosensing.

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Publication history
Copyright
Acknowledgements

Publication history

Received: 04 August 2016
Revised: 23 October 2016
Accepted: 28 October 2016
Published: 07 December 2016
Issue date: March 2017

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016

Acknowledgements

Acknowledgements

This work was financially supported by the National Basic Research Program of China (973 program, No. 2012CB933800) and the National Natural Science Foundation of China (NSFC, No. 91123031).

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