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Research Article

Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

Yu Cai1,§, Weili Si1,§, Qianyun Tang1, Pingping Liang1, Chengwu Zhang1, Peng Chen2, Qi Zhang3( ), Wei Huang1( ), Xiaochen Dong1 ( )
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University (NanjingTech), 30 South Puzhu Road Nanjing 211816 China
School of Chemical and Biomedical Engineering Nanyang Technological University, 70 Nanyang Drive, N1.3-B3-08 Singapore
School of Pharmaceutical Sciences Nanjing Tech University (NanjingTech), 30 South Puzhu Road Nanjing 211816 China

§ These authors contributed equally to this work.

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Abstract

Therapeutic nanoparticles (NPs) based on the donor-acceptor-donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm-2), even at a low dose (0.16 mg·kg-1).

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Keywords

photothermal therapyphotoacoustic imagingdiketopyrrolopyrroledonor-acceptor-donor

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Nano Research
Volume 10 Issue 3,
March 2017
Pages 794-801
DOI: 10.1007/s12274-016-1332-2

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Cite this article:
Cai Y, Si W, Tang Q, et al. Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy. Nano Research, 2017, 10(3): 794-801. https://doi.org/10.1007/s12274-016-1332-2

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Received: 31 August 2016
Revised: 08 October 2016
Accepted: 12 October 2016
Published: 23 December 2016
© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016