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Nano Research 2017, 10(3): 767-775 https://doi.org/10.1007/s12274-016-1289-1
Research Article | Issue | Published: 28 October 2016

Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics

Show Author's Information Geonwook Yoo1,§,  Heekyeong Park2,§,  Minjung Kim2,§,  Won Geun Song2,  Seokhwan Jeong2,  Min Hyung Kim3,  Hyungbeen Lee3,  Sang Woo Lee3,  Young Ki Hong2,  Min Goo Lee4,  Sungho Lee4( ),  Sunkook Kim2( )
School of Electronic Engineering Soongsil University Seoul 06978 Republic of Korea
Multi-Functional Nano/Bio Electronics Lab. Kyung Hee University Gyeonggi 17104 Republic of Korea
Department of Biomedical Engineering Yonsei University Wonju 26493 Republic of Korea
Korea Electronics Technology InstituteGyeonggi 13488 Republic of Korea

§ These authors contributed equally to this work.

Keywords:
MoS2, real-time, point-of-care diagnostics, biosensor, epidermal skin biomarker
An erratum to this article is available online at https://doi.org/10.1007/s12274-017-1499-1
Cite this article:
Yoo G, Park H, Kim M, et al. Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics. Nano Research, 2017, 10(3): 767-775. https://doi.org/10.1007/s12274-016-1289-1
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Abstract Full text About this article

Various approaches have been proposed for point-of-care diagnostics, and in particular, optical detection is preferred because it is relatively simple and fast. At the same time, field-effect transistor (FET)-based biosensors have attracted great attention because they can provide highly sensitive and label-free detection. In this work, we present highly sensitive, epidermal skin-type point-of-care devices with system-level integration of flexible MoS2 FET biosensors, read-out circuits, and light-emitting diode (LEDs) that enable real-time detection of prostate cancer antigens (PSA). Regardless of the physical forms or mechanical stress conditions, our proposed high-performance MoS2 biosensors can detect a PSA concentration of 1 pg·mL-1 without specific surface treatment for anti-PSA immobilization on the MoS2 surface on which we characterize and confirm physisorption of anti-PSA using Kelvin probe force microscopy (KPFM) and tapping-mode atomic force microscopy (tm-AFM). Furthermore, current modulation induced by the binding process was stably maintained for longer than 2-3 min. The results indicate that flexible MoS2-based FET biosensors have great potential for point-of-care diagnostics for prostate cancer as well as other biomarkers.


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About this article

Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics

Show Author's information Geonwook Yoo1,§, Heekyeong Park2,§, Minjung Kim2,§, Won Geun Song2, Seokhwan Jeong2, Min Hyung Kim3, Hyungbeen Lee3, Sang Woo Lee3, Young Ki Hong2, Min Goo Lee4, Sungho Lee4( ), Sunkook Kim2( )
School of Electronic Engineering Soongsil University Seoul 06978 Republic of Korea
Multi-Functional Nano/Bio Electronics Lab. Kyung Hee University Gyeonggi 17104 Republic of Korea
Department of Biomedical Engineering Yonsei University Wonju 26493 Republic of Korea
Korea Electronics Technology InstituteGyeonggi 13488 Republic of Korea

§ These authors contributed equally to this work.

Abstract

Various approaches have been proposed for point-of-care diagnostics, and in particular, optical detection is preferred because it is relatively simple and fast. At the same time, field-effect transistor (FET)-based biosensors have attracted great attention because they can provide highly sensitive and label-free detection. In this work, we present highly sensitive, epidermal skin-type point-of-care devices with system-level integration of flexible MoS2 FET biosensors, read-out circuits, and light-emitting diode (LEDs) that enable real-time detection of prostate cancer antigens (PSA). Regardless of the physical forms or mechanical stress conditions, our proposed high-performance MoS2 biosensors can detect a PSA concentration of 1 pg·mL-1 without specific surface treatment for anti-PSA immobilization on the MoS2 surface on which we characterize and confirm physisorption of anti-PSA using Kelvin probe force microscopy (KPFM) and tapping-mode atomic force microscopy (tm-AFM). Furthermore, current modulation induced by the binding process was stably maintained for longer than 2-3 min. The results indicate that flexible MoS2-based FET biosensors have great potential for point-of-care diagnostics for prostate cancer as well as other biomarkers.

Keywords: MoS2, real-time, point-of-care diagnostics, biosensor, epidermal skin biomarker

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Publication history
Copyright
Acknowledgements

Publication history

Received: 14 June 2016
Revised: 18 August 2016
Accepted: 14 September 2016
Published: 28 October 2016
Issue date: March 2017

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016

Acknowledgements

Acknowledgements

This research was supported in part by the National Research Foundation of Korea (Nos. NRF-2014M3A9 D7070732, and NRF-2015R1A5A1037548). This research was supported by the Commercializations Promotion Agency for R&D Outcomes (COMPA) funded by the Ministry of Science, ICT and Future Planning (MISP).

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