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Nano Research 2016, 9(12): 3812-3827 https://doi.org/10.1007/s12274-016-1251-2
Research Article | Issue | Published: 29 September 2016

Crystallographic facet-dependent stress responses by polyhedral lead sulfide nanocrystals and the potential "safe-by-design" approach

Show Author's Information Yun Chang1,2,  Kai Li2,3,  Yanlin Feng1,2,  Ning Liu1,2,  Yan Cheng1,2,  Xiujuan Sun1,2,  Yuqing Feng4,  Xi Li4( ),  Zhijian Wu2,3( ),  Haiyuan Zhang1,2( )
Laboratory of Chemical BiologyChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China
University of Chinese Academy of SciencesBeijing100049China
State Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China
School of Chemistry and Life ScienceChangchun University of TechnologyChangchun130012China
Keywords:
nanomaterials, toxicity, facet, metal dissolution, safe-by-design
Cite this article:
Chang Y, Li K, Feng Y, et al. Crystallographic facet-dependent stress responses by polyhedral lead sulfide nanocrystals and the potential "safe-by-design" approach. Nano Research, 2016, 9(12): 3812-3827. https://doi.org/10.1007/s12274-016-1251-2
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Abstract Full text Electronic supplementary material About this article

The particular physicochemical properties of nanomaterials are able to elicit unique biological responses. The property activity relationship is usually established for in-depth understanding of toxicity mechanisms and designing safer nanomaterials. In this study, the toxic role of specific crystallographic facets of a series of polyhedral lead sulfide (PbS) nanocrystals, including truncated octahedrons, cuboctahedrons, truncated cubes, and cubes, was investigated in human bronchial epithelial cells (BEAS-2B) and murine alveolar macrophages (RAW 264.7) cells. {100} facets were found capable of triggering facet-dependent cellular oxidative stress and heavy metal stress responses, such as glutathione depletion, lipid peroxidation, reactive oxygen species (ROS) production, heme oxygenase-1 (HO-1) and metallothionein (MT) expression, and mitochondrial dysfunction, while {111} facets remained inert under biological conditions. The {100}-facet-dependent toxicity was ascribed to {100}-facet-dependent lead dissolution, while the low lead dissolution of {111} facets was due to the strong protection afforded by poly(vinyl pyrrolidone) during synthesis. Based on this facet-toxicity relationship, a "safe-by-design" strategy was designed to prevent lead dissolution from {100} facets through the formation of atomically thin lead-chloride adlayers, resulting in safer polyhedral PbS nanocrystals.


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Electronic supplementary material
About this article

Crystallographic facet-dependent stress responses by polyhedral lead sulfide nanocrystals and the potential "safe-by-design" approach

Show Author's information Yun Chang1,2, Kai Li2,3, Yanlin Feng1,2, Ning Liu1,2, Yan Cheng1,2, Xiujuan Sun1,2, Yuqing Feng4, Xi Li4( ), Zhijian Wu2,3( ), Haiyuan Zhang1,2( )
Laboratory of Chemical BiologyChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China
University of Chinese Academy of SciencesBeijing100049China
State Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China
School of Chemistry and Life ScienceChangchun University of TechnologyChangchun130012China

Abstract

The particular physicochemical properties of nanomaterials are able to elicit unique biological responses. The property activity relationship is usually established for in-depth understanding of toxicity mechanisms and designing safer nanomaterials. In this study, the toxic role of specific crystallographic facets of a series of polyhedral lead sulfide (PbS) nanocrystals, including truncated octahedrons, cuboctahedrons, truncated cubes, and cubes, was investigated in human bronchial epithelial cells (BEAS-2B) and murine alveolar macrophages (RAW 264.7) cells. {100} facets were found capable of triggering facet-dependent cellular oxidative stress and heavy metal stress responses, such as glutathione depletion, lipid peroxidation, reactive oxygen species (ROS) production, heme oxygenase-1 (HO-1) and metallothionein (MT) expression, and mitochondrial dysfunction, while {111} facets remained inert under biological conditions. The {100}-facet-dependent toxicity was ascribed to {100}-facet-dependent lead dissolution, while the low lead dissolution of {111} facets was due to the strong protection afforded by poly(vinyl pyrrolidone) during synthesis. Based on this facet-toxicity relationship, a "safe-by-design" strategy was designed to prevent lead dissolution from {100} facets through the formation of atomically thin lead-chloride adlayers, resulting in safer polyhedral PbS nanocrystals.

Keywords: nanomaterials, toxicity, facet, metal dissolution, safe-by-design

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Publication history
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Acknowledgements

Publication history

Received: 04 June 2016
Revised: 09 August 2016
Accepted: 14 August 2016
Published: 29 September 2016
Issue date: December 2016

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016

Acknowledgements

Acknowledgements

This work was primarily supported by the National Natural Science Foundation of China (Nos. 21573216 and 21501170), Hundred Talent Program of CAS, Science and Technology Development Project Foundation of Jilin Province (Nos. 20160101304JC and 20160520134JH), Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, the Start-up fund from Changchun Institute of Applied Chemistry, CAS, and Talent Development fund of Jilin, China.

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