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Research Article

Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers

Ren Cai1, Dan Yang3, Jin Wu3, Liqin Zhang1, Cuichen Wu1, Xigao Chen1, Yanyue Wang1, Shuo Wan1, Fengwei Hou3, Qingyu Yan3, Weihong Tan1,2( )
Department of Chemistry and Department of Physiology and Functional GenomicsCenter for Research at the Bio/Nano InterfaceShands Cancer CenterUF Genetics InstituteMcKnight Brain InstituteUniversity of FloridaGainesville, FL 32611-7200USA
Molecular Sciences and Biomedicine LaboratoryState Key Laboratory for Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical Engineering and College of BiologyCollaborative Innovation Center for Molecular Engineering and TheranosticsHunan UniversityChangsha410082China
School of Materials Science and EngineeringNanyang Technological UniversitySingapore639798Singapore
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Abstract

Ultrathin two-dimensional (2D) porous Zn(OH)2 nanosheets (PNs) were fabricated by means of one-dimensional Cu nanowires as backbones. The PNs have thickness of approximately 3.8 nm and pore size of 4–10 nm. To form "smart" porous nanosheets, DNA aptamers were covalently conjugated to the surface of PNs. These ultrathin nanosheets show good biocompatibility, efficient cellular uptake, and promising pH-stimulated drug release.

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Keywords

aptamerporous Zn(OH)2 nanosheetscancer cellcell-targeted delivery

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Nano Research
Volume 9 Issue 8,
August 2016
Pages 2520-2530
DOI: 10.1007/s12274-016-1138-2

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Cite this article:
Cai R, Yang D, Wu J, et al. Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers. Nano Research, 2016, 9(8): 2520-2530. https://doi.org/10.1007/s12274-016-1138-2

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Received: 28 February 2016
Revised: 02 May 2016
Accepted: 06 May 2016
Published: 10 June 2016
© Tsinghua University Press and Springer‐Verlag Berlin Heidelberg 2016