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Nano Research 2016, 9(7): 2097-2109 https://doi.org/10.1007/s12274-016-1100-3
Research Article | Issue | Published: 20 May 2016

An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel

Show Author's Information Xiaoli Shi1,  Yuting Zhu1,  Wenda Hua1,  Yinglu Ji1,  Qing Ha1,  Xinxiao Han1,  Yang Liu1,  Jingwei Gao1,  Qiang Zhang1,  Sidi Liu1,  Keli Ren1,  Xiaochun Wu1,  Hongyi Li2( ),  Dong Han1( )
National Center for Nanoscience and TechnologyBeijing100190China
Cardiology DivisionBeijing Hospital of the Ministry of HealthBeijing100730China
Keywords:
gold nanospheres, hierarchical multiphase porous medium, intervaginal space injection, in vivo transport, inductively coupled plasma mass spectrometry (ICP-MS)
Cite this article:
Shi X, Zhu Y, Hua W, et al. An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel. Nano Research, 2016, 9(7): 2097-2109. https://doi.org/10.1007/s12274-016-1100-3
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Abstract Full text Electronic supplementary material About this article

The biodistribution of gold nanoparticles (AuNPs) is closely related to toxicological effects and is of great concern because of their potential application in diverse biomedical areas. However, with the discovery of novel anatomic and histological structures for fluid transport, the underlying mechanisms involved in the in vivo transport and biodistribution of AuNPs require further in-depth investigations. In the current study, we investigated the biodistribution of 10-nm AuNPs in rats after intervaginal space injection (ISI) in the tarsal tunnel, where a focal point of tendons, vessels, and nerve fibers may optimally connect to other remote connective tissues. The intravenous injection (IVI) of AuNPs served as a control. The blood and organs were collected at 5, 15, and 30 min and at 1, 4, 12, and 24 h after injection for quantitative analysis of Au distribution with inductively coupled plasma mass spectrometry (ICP-MS). IVI and ISI yielded significantly different results: The AuNP content in the blood after ISI was much lower than that after IVI; was similar in the lungs, heart, and intestines; and was higher in the skin and muscle. These findings were supported by the ratios of AuNP content and relative organ AuNP distribution proportions. Our results demonstrated a fast, direct, and the circulation-independent AuNP–organ transport pathway, which may improve our understanding of physiological and pathological biodistribution processes in biological systems. Furthermore, these results provide novel insights into the in vivo transport and biodistribution of AuNPs, which may lead to novel and efficient therapeutic and administration strategies.


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Electronic supplementary material
About this article

An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel

Show Author's information Xiaoli Shi1, Yuting Zhu1, Wenda Hua1, Yinglu Ji1, Qing Ha1, Xinxiao Han1, Yang Liu1, Jingwei Gao1, Qiang Zhang1, Sidi Liu1, Keli Ren1, Xiaochun Wu1, Hongyi Li2( ), Dong Han1( )
National Center for Nanoscience and TechnologyBeijing100190China
Cardiology DivisionBeijing Hospital of the Ministry of HealthBeijing100730China

Abstract

The biodistribution of gold nanoparticles (AuNPs) is closely related to toxicological effects and is of great concern because of their potential application in diverse biomedical areas. However, with the discovery of novel anatomic and histological structures for fluid transport, the underlying mechanisms involved in the in vivo transport and biodistribution of AuNPs require further in-depth investigations. In the current study, we investigated the biodistribution of 10-nm AuNPs in rats after intervaginal space injection (ISI) in the tarsal tunnel, where a focal point of tendons, vessels, and nerve fibers may optimally connect to other remote connective tissues. The intravenous injection (IVI) of AuNPs served as a control. The blood and organs were collected at 5, 15, and 30 min and at 1, 4, 12, and 24 h after injection for quantitative analysis of Au distribution with inductively coupled plasma mass spectrometry (ICP-MS). IVI and ISI yielded significantly different results: The AuNP content in the blood after ISI was much lower than that after IVI; was similar in the lungs, heart, and intestines; and was higher in the skin and muscle. These findings were supported by the ratios of AuNP content and relative organ AuNP distribution proportions. Our results demonstrated a fast, direct, and the circulation-independent AuNP–organ transport pathway, which may improve our understanding of physiological and pathological biodistribution processes in biological systems. Furthermore, these results provide novel insights into the in vivo transport and biodistribution of AuNPs, which may lead to novel and efficient therapeutic and administration strategies.

Keywords: gold nanospheres, hierarchical multiphase porous medium, intervaginal space injection, in vivo transport, inductively coupled plasma mass spectrometry (ICP-MS)

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Publication history
Copyright
Acknowledgements

Publication history

Received: 18 September 2015
Revised: 10 April 2016
Accepted: 14 April 2016
Published: 20 May 2016
Issue date: July 2016

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016

Acknowledgements

Acknowledgements

This work was supported by the National Basic Research Program of China (Nos. 2015CB5545507 and 2013CB933700) and the National Natural Science Foundation of China (No. 21305024).

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