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Research Article

Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation

Gaofei Hu, Juan Tang, Xilin Bai, Suying Xu, Leyu Wang ( )
State Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijing100029China
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Abstract

Copper sulfide (Cu7S4) nanoparticles coated with an ultra-high payload (~5.0 × 107 fluorine atoms per particle) of fluorinated ligands (oleylamine functionalized 3, 5-bis(trifluoromethyl)benzaldehyde, 19FOAm) exhibited a single intense 19F magnetic resonance (MR) signal and efficient near infrared photothermal performance in water medium. In vivo assessment revealed strong 19F MR signals at cancerous lesions and effective inhibition of tumor growth after photothermal treatment, indicating the great potential of these fabricated nanoprobes for simultaneous 19F MR imaging and photothermal therapy.

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Keywords

19F magnetic resonance imagingphotothermal therapy

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Nano Research
Volume 9 Issue 6,
June 2016
Pages 1630-1638
DOI: 10.1007/s12274-016-1057-2

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Cite this article:
Hu G, Tang J, Bai X, et al. Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation. Nano Research, 2016, 9(6): 1630-1638. https://doi.org/10.1007/s12274-016-1057-2

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Received: 27 January 2015
Revised: 21 February 2016
Accepted: 22 February 2016
Published: 08 April 2016
© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016