Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation
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Copper sulfide (Cu7S4) nanoparticles coated with an ultra-high payload (~5.0 × 107 fluorine atoms per particle) of fluorinated ligands (oleylamine functionalized 3, 5-bis(trifluoromethyl)benzaldehyde, 19FOAm) exhibited a single intense 19F magnetic resonance (MR) signal and efficient near infrared photothermal performance in water medium. In vivo assessment revealed strong 19F MR signals at cancerous lesions and effective inhibition of tumor growth after photothermal treatment, indicating the great potential of these fabricated nanoprobes for simultaneous 19F MR imaging and photothermal therapy.
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Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation
)
Abstract
Copper sulfide (Cu7S4) nanoparticles coated with an ultra-high payload (~5.0 × 107 fluorine atoms per particle) of fluorinated ligands (oleylamine functionalized 3, 5-bis(trifluoromethyl)benzaldehyde, 19FOAm) exhibited a single intense 19F magnetic resonance (MR) signal and efficient near infrared photothermal performance in water medium. In vivo assessment revealed strong 19F MR signals at cancerous lesions and effective inhibition of tumor growth after photothermal treatment, indicating the great potential of these fabricated nanoprobes for simultaneous 19F MR imaging and photothermal therapy.
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Acknowledgements
This research was supported in part by the National Natural Science Foundation of China (Nos. 21475007, 21275015, and 21505003) and the Fundamental Research Funds for the Central Universities (Nos. YS1406, buctrc201507, and buctrc201608). We also thank Prof. X. Zhang and Dr. M. Song in Xiamen University for helping 19F-MR imaging, and the support from the "Innovation and Promotion Project of BUCT", the "Public Hatching Platform for Recruited Talents of BUCT" and BUCT Fund for Disciplines Construction and Development (No. XK1526).
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