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Nano Research 2016, 9(5): 1418-1425 https://doi.org/10.1007/s12274-016-1037-6
Research Article | Issue | Published: 29 September 2016

Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis

Show Author's Information Yuxiu Zou1,§,  Long Chen2,§,  Zhiling Song1,  Ding Ding1,  Yiqin Chen3,  Yiting Xu1,  Shanshan Wang1,  Xiaofang Lai1,  Yin Zhang1,  Yang Sun1,  Zhuo Chen1( ),  Weihong Tan1( )
Molecular Science and Biomedicine LaboratoryState Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyHunan UniversityChangsha410082China
Faculty of Science and TechnologyUniversity of MacauE11Avenida da UniversidadeTaipaMacau999078China
School of Physics and ElectronicsState Key Laboratory for Chemo/ Biosensing and ChemometricsHunan UniversityChangsha410082China

§These authors contributed equally to this work.

Keywords:
graphitic nanomaterials, analytical methods, internal standards, quantitative analysis, surface-enhanced Raman spectroscopy (SERS)
Cite this article:
Zou Y, Chen L, Song Z, et al. Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis. Nano Research, 2016, 9(5): 1418-1425. https://doi.org/10.1007/s12274-016-1037-6
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Abstract Full text Electronic supplementary material About this article

Graphitic nanomaterials have unique, strong, and stable Raman vibrations that have been widely applied in chemistry and biomedicine. However, utilizing them as internal standards (ISs) to improve the accuracy of surface-enhanced Raman spectroscopy (SERS) analysis has not been attempted. Herein, we report the design of a unique IS nanostructure consisting of a large number of gold nanoparticles (AuNPs) decorated on multilayered graphitic magnetic nanocapsules (AGNs) to quantify the analyte and eliminate the problems associated with traditional ISs. The AGNs demonstrated a unique Raman band from the graphitic component, which was localized in the Raman silent region of the biomolecules, making them an ideal IS for quantitative Raman analysis without any background interference. The IS signal from the AGNs also indicated superior stability, even under harsh conditions. With the enhancement of the decorated AuNPs, the AGN nanostructures greatly improved the quantitative accuracy of SERS, in particular the exclusion of quantitative errors resulting from collection loss and non-uniform distribution of the analytes. The AGNs were further utilized for cell staining and Raman imaging, and they showed great promise for applications in biomedicine.


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Electronic supplementary material
About this article

Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis

Show Author's information Yuxiu Zou1,§, Long Chen2,§, Zhiling Song1, Ding Ding1, Yiqin Chen3, Yiting Xu1, Shanshan Wang1, Xiaofang Lai1, Yin Zhang1, Yang Sun1, Zhuo Chen1( ), Weihong Tan1( )
Molecular Science and Biomedicine LaboratoryState Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyHunan UniversityChangsha410082China
Faculty of Science and TechnologyUniversity of MacauE11Avenida da UniversidadeTaipaMacau999078China
School of Physics and ElectronicsState Key Laboratory for Chemo/ Biosensing and ChemometricsHunan UniversityChangsha410082China

§These authors contributed equally to this work.

Abstract

Graphitic nanomaterials have unique, strong, and stable Raman vibrations that have been widely applied in chemistry and biomedicine. However, utilizing them as internal standards (ISs) to improve the accuracy of surface-enhanced Raman spectroscopy (SERS) analysis has not been attempted. Herein, we report the design of a unique IS nanostructure consisting of a large number of gold nanoparticles (AuNPs) decorated on multilayered graphitic magnetic nanocapsules (AGNs) to quantify the analyte and eliminate the problems associated with traditional ISs. The AGNs demonstrated a unique Raman band from the graphitic component, which was localized in the Raman silent region of the biomolecules, making them an ideal IS for quantitative Raman analysis without any background interference. The IS signal from the AGNs also indicated superior stability, even under harsh conditions. With the enhancement of the decorated AuNPs, the AGN nanostructures greatly improved the quantitative accuracy of SERS, in particular the exclusion of quantitative errors resulting from collection loss and non-uniform distribution of the analytes. The AGNs were further utilized for cell staining and Raman imaging, and they showed great promise for applications in biomedicine.

Keywords: graphitic nanomaterials, analytical methods, internal standards, quantitative analysis, surface-enhanced Raman spectroscopy (SERS)

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Publication history
Copyright
Acknowledgements

Publication history

Received: 25 December 2015
Revised: 29 January 2016
Accepted: 03 February 2016
Published: 29 September 2016
Issue date: May 2016

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016

Acknowledgements

Acknowledgements

This work was financially supported by the National Basic Research Program of China (No. 2013CB932702), the Research Fund for the Program on National Key Scientific Instruments and Equipment Development of China (No. 2011YQ0301241402), the National Natural Science Foundation of China (No. 21522501), the Science and Technology Development Fund of Macao S.A.R (FDCT, 067/2014/A), and the Hunan Innovation and Entrepreneurship Program.

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