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Research Article

TbF3 nanoparticles as dual-mode contrast agents for ultrahigh field magnetic resonance imaging and X-ray computed tomography

Xiaoyu Zheng, Yanjie Wang, Lingdong Sun( ), Naixiu Chen, Lindong Li, Shuo Shi, Sivakumar Malaisamy, Chunhua Yan( )
Beijing National Laboratory for Molecular SciencesState Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China
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Abstract

Considering the development of magnetic resonance imaging (MRI) under ultrahigh magnetic field (> 3 T), the exploration of novel contrast agents (CAs) for ultrahigh field MRI is urgently needed. Herein, we report polyethyleneimine (PEI)-coated TbF3 nanoparticles (NPs), which were synthesized by a facile solvothermal method, as potential dual-mode CAs for ultrahigh field MRI and X-ray computed tomography (CT). Owing to their strong paramagnetism, the TbF3 NPs showed excellent transverse relaxivity (395.77 mM–1·s–1) and negligible longitudinal relaxivity under an ultrahigh magnetic field (7 T) with a great potential as a T2-weighted MRI contrast agent. Furthermore, by comparison with the clinically used CT CAs (iohexol), the TbF3 NPs showed superior X-ray attenuation ability. The practical application for T2-weighted MRI and CT imaging was demonstrated with an animal model. Moreover, cell cytotoxicity and in vivo toxicity assessments implied the low toxicity of TbF3 NPs. In summary, the above results indicate that TbF3 NPs are promising candidates for ultrahigh field MRI and CT dual-mode imaging.

Keywords

nanoparticleTbF3magnetic resonance imaging (MRI)computed tomography (CT)contrast agent

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Nano Research
Volume 9 Issue 4,
April 2016
Pages 1135-1147
DOI: 10.1007/s12274-016-1008-y
Cite this article:
Zheng X, Wang Y, Sun L, et al. TbF3 nanoparticles as dual-mode contrast agents for ultrahigh field magnetic resonance imaging and X-ray computed tomography. Nano Research, 2016, 9(4): 1135-1147. https://doi.org/10.1007/s12274-016-1008-y

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Received: 11 November 2015
Revised: 03 January 2016
Accepted: 05 January 2016
Published: 07 March 2016
© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016
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