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A universal platform with Mn doping and hyaluronic acid (HA) modification, based on mesoporous silica (mSiO2), was designed and used as a basic multifunctional material with magnetic resonance (MR) imaging. Furthermore, we added flexible functions through the addition of functional molecules. Specially, two typical compounds, hydrophobic perfluorooctyl bromide (PFOB) and hydrophilic doxorubicin (DOX), were loaded into the channels to obtain PFOB@Mn@mSiO2@HA (PMMH) or DOX@Mn@mSiO2@HA (DMMH) nanoparticles for dual-mode imaging or imaging and therapy, respectively. The PMMH and DMMH nanoparticles were highly targeted to the lymph system in vitro and in vivo. MR and ultrasound imaging of PMMH nanoparticles were performed in the lymph system, while MR imaging and chemotherapy of DMMH nanoparticles was used to detect cancer. These results showed that both PMMH and DMMH nanoparticles can be designed with high lymph targeting efficiency. PMMH nanoparticles are a dual-mode contrast agent for both ultrasound and MR imaging for the lymph system and DMMH nanoparticles are powerful agents for the combined diagnosis and therapy of cancer in vivo.

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nr-9-2-473_ESM.pdf (1.4 MB)
Publication history
Copyright
Acknowledgements

Publication history

Received: 10 August 2015
Revised: 12 October 2015
Accepted: 27 October 2015
Published: 25 November 2015
Issue date: February 2016

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015

Acknowledgements

Acknowledgements

The work is supported by Shanghai Rising-Star Program (No. 13QB1402200), Shanghai Minhang district talent development special fund, National Key Technology Research and Development Program (No. 2014BAK05B02) and National Natural Science Foundation of China (Nos. 81271638 and 81371622).

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