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Nano Research 2015, 8(12): 4038-4047 https://doi.org/10.1007/s12274-015-0905-9
Research Article | Issue | Published: 05 November 2015

Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release

Show Author's Information Sheng Huang1,§,  Jing Liu2,§,  Qian He1,  Hongli Chen1,  Jiabin Cui1,  Suying Xu1,  Yuliang Zhao2,  Chunying Chen2( ),  Leyu Wang1( )
State Key Laboratory of Chemical Resource EngineeringBeijing Key Laboratory of Environmentally Harmful Chemical AnalysisBeijing University of Chemical TechnologyBeijing100029China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of China and Institute of High Energy PhysicsChinese Academy of SciencesBeijing100190China

§ These authors contributed equally to this work.

Keywords:
drug release, photothermal therapy, copper sulfides, near infrared light
Cite this article:
Huang S, Liu J, He Q, et al. Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release. Nano Research, 2015, 8(12): 4038-4047. https://doi.org/10.1007/s12274-015-0905-9
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Abstract Full text Electronic supplementary material About this article

Thermosensitive drug delivery systems (DDSs) face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near-infrared (NIR) photothermal Cu1.75S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine (DOX) loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions (pH = 7.4, 37 ℃) for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous longterm NIR irradiation. Based on the stable and high photothermal efficiency (55.8%), pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstrating remote and noninvasive control.


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Electronic supplementary material
About this article

Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release

Show Author's information Sheng Huang1,§, Jing Liu2,§, Qian He1, Hongli Chen1, Jiabin Cui1, Suying Xu1, Yuliang Zhao2, Chunying Chen2( ), Leyu Wang1( )
State Key Laboratory of Chemical Resource EngineeringBeijing Key Laboratory of Environmentally Harmful Chemical AnalysisBeijing University of Chemical TechnologyBeijing100029China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of China and Institute of High Energy PhysicsChinese Academy of SciencesBeijing100190China

§ These authors contributed equally to this work.

Abstract

Thermosensitive drug delivery systems (DDSs) face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near-infrared (NIR) photothermal Cu1.75S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine (DOX) loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions (pH = 7.4, 37 ℃) for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous longterm NIR irradiation. Based on the stable and high photothermal efficiency (55.8%), pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstrating remote and noninvasive control.

Keywords: drug release, photothermal therapy, copper sulfides, near infrared light

References(34)

1

Peng, Z. Y.; Qin, J. B.; Li, B.; Ye, K. C.; Zhang, Y. X.; Yang, X. R.; Yuan, F. K.; Huang, L. J.; Hu, J. Q.; Lu, X. W. An effective approach to reduce inflammation and stenosis in carotid artery: Polypyrrole nanoparticle-based photothermal therapy. Nanoscale 2015, 7, 7682-7691.
DOI Google Scholar
2

Hu, X. L.; Liu, G. H.; Li, Y.; Wang, X. R.; Liu, S. Y. Cell-penetrating hyperbranched polyprodrug amphiphiles for synergistic reductive milieu-triggered drug release and enhanced magnetic resonance signals. J. Am. Chem. Soc. 2015, 137, 362-368.
DOI Google Scholar
3

Huang, S.; Peng, S.; Li, Y. B.; Cui, J. B.; Chen, H. L.; Wang, L. Y. Development of NIR-II fluorescence image-guided and pH-responsive nanocapsules for cocktail drug delivery. Nano Res. 2015, 8, 1932-1943.
DOI Google Scholar
4

He, Q.; Huang, S.; Xu, S. Y.; Wang, L. Y. pH-responsive cocktail drug nanocarriers by encapsulating paclitaxel with doxorubicin modified poly(amino acid). RSC Adv. 2015, 5, 43148-43154.
DOI Google Scholar
5

Bai, X. L.; Wang, S. G.; Xu, S. Y.; Wang, L. Y. Luminescent nanocarriers for simultaneous drug or gene delivery and imaging tracking. TrAC-Trends Anal. Chem. 2015, 73, 54-63.
DOI Google Scholar
6

Bai, M.; Bai, X. L.; Wang, L. Y. Real-time fluorescence tracking of gene delivery via multifunctional nanocomposites. Anal. Chem. 2014, 86, 11196-11202.
DOI Google Scholar
7

Li, X. M.; Zhou, L.; Wei, Y.; El-Toni, A. M.; Zhang, F.; Zhao, D. Y. Anisotropic growth-induced synthesis of dual- compartment janus mesoporous silica nanoparticles for bimodal triggered drugs delivery. J. Am. Chem. Soc. 2014, 136, 15086-15092.
DOI Google Scholar
8

Xiao, Q. F.; Zheng, X. P.; Bu, W. B.; Ge, W. Q.; Zhang, S. J.; Chen, F.; Xing, H. Y.; Ren, Q. G.; Fan, W. P.; Zhao, K. L. et al. A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy. J. Am. Chem. Soc. 2013, 135, 13041- 13048.
DOI Google Scholar
9

Kong, S. D.; Zhang, W. Z.; Lee, J. H.; Brammer, K.; Lal, R.; Karin, M.; Jin, S. H. Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release. Nano Lett. 2010, 10, 5088-5092.
DOI Google Scholar
10

Nakayama, M.; Okano, T.; Miyazaki, T.; Kohori, F.; Sakai, K.; Yokoyama, M. Molecular design of biodegradable polymeric micelles for temperature-responsive drug release. J. Control. Release 2006, 115, 46-56.
DOI Google Scholar
11

Zhang, Z. J.; Wang, J.; Nie, X.; Wen, T.; Ji, Y. L.; Wu, X. C.; Zhao, Y. L.; Chen, C. Y. Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods. J. Am. Chem. Soc. 2014, 136, 7317-7326.
DOI Google Scholar
12

Yavuz, M. S.; Cheng, Y. Y.; Chen, J. Y.; Cobley, C. M.; Zhang, Q.; Rycenga, M.; Xie, J. W.; Kim, C.; Song, K. H.; Schwartz, A. G. et al. Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nat. Mater. 2009, 8, 935-939.
DOI Google Scholar
13

Kumar, A.; Kumar, S.; Rhim, W. K.; Kim, G. H.; Nam, J. M. Oxidative nanopeeling chemistry-based synthesis and photodynamic and photothermal therapeutic applications of plasmonic core-petal nanostructures. J. Am. Chem. Soc. 2014, 136, 16317-16325.
DOI Google Scholar
14

Xu, Y. Y.; Wang, J.; Li, X. F.; Liu, Y.; Dai, L. R.; Wu, X. C.; Chen, C. Y. Selective inhibition of breast cancer stem cells by gold nanorods mediated plasmonic hyperthermia. Biomaterials 2014, 35, 4667-4677.
DOI Google Scholar
15

Skrabalak, S. E.; Chen, J. Y.; Sun, Y. G.; Lu, X. M.; Au, L.; Cobley, C. M.; Xia, Y. N. Gold nanocages: Synthesis, properties, and applications. Accounts Chem. Res. 2008, 41, 1587-1595.
DOI Google Scholar
16

Ma, Y.; Liang, X. L.; Tong, S.; Bao, G.; Ren, Q. S.; Dai, Z. F. Gold nanoshell nanomicelles for potential magnetic resonance imaging, light-triggered drug release, and photothermal therapy. Adv. Funct. Mater. 2013, 23, 815-822.
DOI Google Scholar
17

Ye, E. Y.; Win, K. Y.; Tan, H. R.; Lin, M.; Teng, C. P.; Mlayah, A.; Han, M. Y. Plasmonic gold nanocrosses with multidirectional excitation and strong photothermal effect. J. Am. Chem. Soc. 2011, 133, 8506-8509.
DOI Google Scholar
18

Wang, C.; Xu, L. G.; Liang, C.; Xiang, J.; Peng, R.; Liu, Z. Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to inhibit cancer metastasis. Adv. Mater. 2014, 26, 8154-8162.
DOI Google Scholar
19

Robinson, J. T.; Tabakman, S. M.; Liang, Y. Y.; Wang, H. L.; Casalongue, H. S.; Vinh, D.; Dai, H. J. Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J. Am. Chem. Soc. 2011, 133, 6825-6831.
DOI Google Scholar
20

Cheng, L.; Liu, J. J.; Gu, X.; Gong, H.; Shi, X. Z.; Liu, T.; Wang, C.; Wang, X. Y.; Liu, G.; Xing, H. Y. et al. PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv. Mater. 2014, 26, 1886-1893.
DOI Google Scholar
21

Chou, S. S.; Kaehr, B.; Kim, J.; Foley, B. M.; De, M.; Hopkins, P. E.; Huang, J. X.; Brinker, C. J.; Dravid, V. P. Chemically exfoliated MoS2 as near-infrared photothermal agents. Angew. Chem., Int. Ed. 2013, 52, 4160-4164.
DOI Google Scholar
22

Tian, Q. W.; Jiang, F. R.; Zou, R. J.; Liu, Q.; Chen, Z. G.; Zhu, M. F.; Yang, S. P.; Wang, J. L.; Wang, J. H.; Hu, J. Q. Hydrophilic Cu9S5 nanocrystals: A photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano 2011, 5, 9761-9771.
DOI Google Scholar
23

Tian, Q. W.; Tang, M. H.; Sun, Y. G.; Zou, R. J.; Chen, Z. G.; Zhu, M. F.; Yang, S. P.; Wang, J. L.; Wang, J. H.; Hu, J. Q. Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells. Adv. Mater. 2011, 23, 3542-3547.
DOI Google Scholar
24

Cui, J. B.; Li, Y. J.; Liu, L.; Chen, L.; Xu, J.; Ma, J. W.; Fang, G.; Zhu, E. B.; Wu, H.; Zhao, L. X. et al. Near-infrared plasmonic-enhanced solar energy harvest for highly efficient photocatalytic reactions. Nano Lett. 2015, 15, 6295-6301.
DOI Google Scholar
25

Cui, J. B.; Jiang, R.; Xu, S. Y.; Hu, G. F.; Wang, L. Y. Cu7S4 nanosuperlattices with greatly enhanced photothermal efficiency. Small 2015, 11, 4183-4190.
DOI Google Scholar
26

Xie, Y.; Carbone, L.; Nobile, C.; Grillo, V.; D'Agostino, S.; Della Sala, F.; Giannini, C.; Altamura, D.; Oelsner, C.; Kryschi, C. et al. Metallic-like stoichiometric copper sulfide nanocrystals: Phase- and shape-selective synthesis, near- infrared surface plasmon resonance properties, and their modeling. ACS Nano 2013, 7, 7352-7369.
DOI Google Scholar
27

Zhao, Y. X.; Pan, H. C.; Lou, Y. B.; Qiu, X. F.; Zhu, J. J.; Burda, C. Plasmonic Cu2-xS nanocrystals: Optical and structural properties of copper-deficient copper(I) sulfides. J. Am. Chem. Soc. 2009, 131, 4253-4261.
DOI Google Scholar
28

Ding, X. G.; Liow, C. H.; Zhang, M. X.; Huang, R. J.; Li, C. Y.; Shen, H.; Liu, M. Y.; Zou, Y.; Gao, N.; Zhang, Z. J. et al. Surface plasmon resonance enhanced light absorption and photothermal therapy in the second near-infrared window. J. Am. Chem. Soc. 2014, 136, 15684-15693.
DOI Google Scholar
29

Mountain, B. W.; Seward, T. M. Hydrosulfide/sulfide complexes of copper(I): Experimental confirmation of the stoichiometry and stability of Cu(HS)2- to elevated temperatures. Geochim. Cosmochim. Acta 2003, 67, 3005-3014.
DOI Google Scholar
30

Hessel, C. M.; Pattani, V. P.; Rasch, M.; Panthani, M. G.; Koo, B.; Tunnell, J. W.; Korgel, B. A. Copper selenide nanocrystals for photothermal therapy. Nano Lett. 2011, 11, 2560-2566.
DOI Google Scholar
31

Shi, J. J.; Wang, L.; Zhang, J.; Ma, R.; Gao, J.; Liu, Y.; Zhang, C. F.; Zhang, Z. Z. A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@Ag nanoparticles for chemo-photothermal therapy and X-ray imaging. Biomaterials 2014, 35, 5847-5861.
DOI Google Scholar
32

Roper, D. K.; Ahn, W.; Hoepfner, M. Microscale heat transfer transduced by surface plasmon resonant gold nanoparticles. J. Phys. Chem. C 2007, 111, 3636-3641.
DOI Google Scholar
33

Li, B.; Wang, Q.; Zou, R. J.; Liu, X. J.; Xu, K. B.; Li, W. Y.; Hu, J. Q. Cu7.2S4 nanocrystals: A novel photothermal agent with a 56.7% photothermal conversion efficiency for photothermal therapy of cancer cells. Nanoscale 2014, 6, 3274-3282.
DOI Google Scholar
34

Kim, H.; Lee, D.; Kim, J.; Kim, T. I.; Kim, W. J. Photothermally triggered cytosolic drug delivery via endosome disruption using a functionalized reduced graphene oxide. ACS Nano 2013, 7, 6735-6746.
DOI Google Scholar
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Publication history
Copyright
Acknowledgements

Publication history

Received: 01 August 2015
Revised: 16 September 2015
Accepted: 25 September 2015
Published: 05 November 2015
Issue date: December 2015

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015

Acknowledgements

Acknowledgements

The financial support was provided by the National Natural Science Foundation of China (Nos. 21475007 and 21275015), the National Basic Research Program of China (No. 2011CB932403), and the Fundamental Research Funds for the Central Universities (No. YS1406). We also thank the support from the "Innovation and Promotion Project of Beijing University of Chemical Technology" and the "Public Hatching Platform for Recruited Talents of Beijing University of Chemical Technology".

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