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Nano Research 2015, 8(11): 3580-3590 https://doi.org/10.1007/s12274-015-0858-z
Research Article | Issue | Published: 16 September 2015

Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/photodynamic/radiation synergistic cancer therapy

Show Author's Information Jianjian Qiu1,§,  Qingfeng Xiao2,§,  Xiangpeng Zheng1( ),  Libo Zhang1,  Huaiyong Xing2,  Dalong Ni2,  Yanyan Liu2,  Shengjian Zhang3,  Qingguo Ren4,  Yanqing Hua4,  Kuaile Zhao5,  Wenbo Bu2( )
Department of Radiation OncologyFudan University Huadong HospitalShanghai200040China
State Key Laboratory of High performance Ceramics and Superfine MicrostructuresShanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China
Department of RadiologyShanghai Cancer HospitalFudan UniversityShanghai200032China
Department of RadiologyFudan University Huadong HospitalShanghai200032China
Department of Radiation OncologyShanghai Cancer HospitalFudan UniversityShanghai200032China

§ These authors contributed equally to this work.

Keywords:
photodynamic therapy, photothermal therapy, synergistic therapy, radiation therapy, radiosensitization, image guidance
Cite this article:
Qiu J, Xiao Q, Zheng X, et al. Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/photodynamic/radiation synergistic cancer therapy. Nano Research, 2015, 8(11): 3580-3590. https://doi.org/10.1007/s12274-015-0858-z
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Abstract Full text Electronic supplementary material About this article

Combination therapy is a promising cancer treatment strategy that is usually based on the utilization of complicated nanostructures with multiple components functioning as photo-thermal energy transducers, photo-sensitizers, or dose intensifiers for photothermal therapy (PTT), photodynamic therapy (PDT), or radiation therapy (RT). In this study, ultrathin tungsten oxide nanowires (W18O49) were synthesized using a solvothermal approach and examined as a multifunctional theranostic nanoplatform. In vitro and in vivo analyses demonstrated that these nanowires could induce extensive heat- and singlet oxygen-mediated damage to cancer cells under 980 nm near infrared (NIR)-laser excitation. They were also shown to function as radiation dose intensifying agents that enhance irradiative energy deposition locally and selectively during radiation therapy. Compared to NIR-induced PTT/PDT and RT alone, W18O49-based synergistic tri-modal therapy eradicated xenograft tumors and no recurrence was observed within a 9-month follow up. Moreover, the strong X-ray attenuation ability of the tungsten element (Z = 74, 4.438 cm2·g-1, 100 KeV) qualified these nanowires as excellent contrast agents in X-ray-based imaging, such as diagnostic computed tomography (CT) and cone-beam CT for image-guided radiation therapy. Toxicity studies demonstrated minimal adverse effects on the hematologic system and major organs of mice within one month. In conclusion, these nanowires have shown significant potential for cancer therapy with inherent image guidance and synergistic effects from phototherapy and radiation therapy, which warrants further investigation.


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Abstract
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Electronic supplementary material
About this article

Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/photodynamic/radiation synergistic cancer therapy

Show Author's information Jianjian Qiu1,§, Qingfeng Xiao2,§, Xiangpeng Zheng1( ), Libo Zhang1, Huaiyong Xing2, Dalong Ni2, Yanyan Liu2, Shengjian Zhang3, Qingguo Ren4, Yanqing Hua4, Kuaile Zhao5, Wenbo Bu2( )
Department of Radiation OncologyFudan University Huadong HospitalShanghai200040China
State Key Laboratory of High performance Ceramics and Superfine MicrostructuresShanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China
Department of RadiologyShanghai Cancer HospitalFudan UniversityShanghai200032China
Department of RadiologyFudan University Huadong HospitalShanghai200032China
Department of Radiation OncologyShanghai Cancer HospitalFudan UniversityShanghai200032China

§ These authors contributed equally to this work.

Abstract

Combination therapy is a promising cancer treatment strategy that is usually based on the utilization of complicated nanostructures with multiple components functioning as photo-thermal energy transducers, photo-sensitizers, or dose intensifiers for photothermal therapy (PTT), photodynamic therapy (PDT), or radiation therapy (RT). In this study, ultrathin tungsten oxide nanowires (W18O49) were synthesized using a solvothermal approach and examined as a multifunctional theranostic nanoplatform. In vitro and in vivo analyses demonstrated that these nanowires could induce extensive heat- and singlet oxygen-mediated damage to cancer cells under 980 nm near infrared (NIR)-laser excitation. They were also shown to function as radiation dose intensifying agents that enhance irradiative energy deposition locally and selectively during radiation therapy. Compared to NIR-induced PTT/PDT and RT alone, W18O49-based synergistic tri-modal therapy eradicated xenograft tumors and no recurrence was observed within a 9-month follow up. Moreover, the strong X-ray attenuation ability of the tungsten element (Z = 74, 4.438 cm2·g-1, 100 KeV) qualified these nanowires as excellent contrast agents in X-ray-based imaging, such as diagnostic computed tomography (CT) and cone-beam CT for image-guided radiation therapy. Toxicity studies demonstrated minimal adverse effects on the hematologic system and major organs of mice within one month. In conclusion, these nanowires have shown significant potential for cancer therapy with inherent image guidance and synergistic effects from phototherapy and radiation therapy, which warrants further investigation.

Keywords: photodynamic therapy, photothermal therapy, synergistic therapy, radiation therapy, radiosensitization, image guidance

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Publication history
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Acknowledgements

Publication history

Received: 18 March 2015
Revised: 04 July 2015
Accepted: 09 July 2015
Published: 16 September 2015
Issue date: November 2015

Copyright

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2015

Acknowledgements

Acknowledgements

This work has been financially supported by the National Natural Science Foundation of China (Nos. 51372260, 51132009, and 21172043), the Shanghai Rising-Star Program (No. 12QH1402500), the Science and Technology Commission of Shanghai (No. 11nm0505000 and 124119a0400), the Shanghai Municipal Commission of Health (No. 20134360), the Development Foundation for Talents of Shanghai (No. 2012035).

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