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Research Article

X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations

Slávka Kaščáková1,2, Alexandre Giuliani1,3, Sara Lacerda4, Agnès Pallier4, Pascal Mercère1, Éva Tóth4, Matthieu Réfrégiers1( )
Synchrotron SOLEILL'Orme des Merisiers91190Gif-sur-Yvette, France
UMR-S1193Université Paris-Sud XI94800Villejuif, France
INRACaractérisation et Élaboration des Produits Issus de l'Agriculture44316Nantes, France
Centre de Biophysique MoléculaireCNRSRue Charles Sadron45071Orléans Cedex 2, France
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Abstract

We report lanthanide-based micelles integrating hypericin (Hyp) for X-ray-triggered photodynamic therapy (PDT). The lanthanide luminescence induced by X-ray irradiation excites the photosensitizer, which leads to the generation of singlet oxygen. This versatile approach can be extended to other photosensitizers or other types of liponanoparticles and can allow for magnetic resonance imaging (MRI) guidance.

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Keywords

photodynamic therapyliponanoparticlesX-raydeep tumourphotosensitizer

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Nano Research
Volume 8 Issue 7,
July 2015
Pages 2373-2379
DOI: 10.1007/s12274-015-0747-5

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Kaščáková S, Giuliani A, Lacerda S, et al. X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations. Nano Research, 2015, 8(7): 2373-2379. https://doi.org/10.1007/s12274-015-0747-5

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Received: 24 December 2014
Revised: 03 February 2015
Accepted: 10 February 2015
Published: 20 May 2015
© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015