X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations
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We report lanthanide-based micelles integrating hypericin (Hyp) for X-ray-triggered photodynamic therapy (PDT). The lanthanide luminescence induced by X-ray irradiation excites the photosensitizer, which leads to the generation of singlet oxygen. This versatile approach can be extended to other photosensitizers or other types of liponanoparticles and can allow for magnetic resonance imaging (MRI) guidance.
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X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations
Abstract
We report lanthanide-based micelles integrating hypericin (Hyp) for X-ray-triggered photodynamic therapy (PDT). The lanthanide luminescence induced by X-ray irradiation excites the photosensitizer, which leads to the generation of singlet oxygen. This versatile approach can be extended to other photosensitizers or other types of liponanoparticles and can allow for magnetic resonance imaging (MRI) guidance.
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Acknowledgements
Data collection was performed on the METROLOGY and DISCO beamline (using the Biology support lab) at Synchrotron SOLEIL, France. We thank Dr. Célia Bonnet for her help in the preparation of the micelles, and Dr Frédéric Jamme, Valérie Rouam and Paulo Da Silva for their help and technical support. We are grateful to the SOLEIL synchrotron for general facilities placed at our disposure. This research was supported by SOLEIL (No. 20100575) and the Regional Council of the Région Centre (convention SOLEIL/Région Centre 201100070573 - DEEP-PDT).
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