AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Research Article
Article Link
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article

Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo

Yinyin Chen1,2, Shi Liu2,3, Zhiyao Hou1, Pingan Ma1, Dongmei Yang1,2, Chunxia Li1( ), Jun Lin1( )
State Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130024China
University of the Chinese Academy of SciencesBeijing100049China
State Key Laboratory of Polymer Physics and ChemistryChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130024China
Show Author Information

Abstract

A multifunctional, dual-drug carrier platform was successfully constructed. Core-shell structured NaGdF4: Yb/Er@NaGdF4: Yb@mSiO2-polyethylene glycol (abbreviated as UCNPS) nanoparticles loaded with the antitumor drug, doxorubicin (DOX) were incorporated into poly(ε-caprolactone) (PCL) and gelatin loaded with antiphlogistic drug, indomethacin (MC) to form nanofibrous fabrics (labeled as MC/UCNPS/DOX) via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide (SiO2) and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4: Yb/Er@NaGdF4: Yb embedded in MC/UCNPS/DOX in vivo.

Graphical Abstract

Keywords

electrospinning orthotopictreatmentcontrolled releasemultiple structure

Electronic Supplementary Material

Download File(s)
12274_2014_701_MOESM1_ESM.pdf (596.5 KB)

References

【1】
【1】
 
 
Crossref Google Scholar
Nano Research
Volume 8 Issue 6,
June 2015
Pages 1917-1931
DOI: 10.1007/s12274-014-0701-y

{{item.num}}

Comments on this article

Go to comment

< Back to all reports

Review Status: {{reviewData.commendedNum}} Commended , {{reviewData.revisionRequiredNum}} Revision Required , {{reviewData.notCommendedNum}} Not Commended Under Peer Review

Review Comment

Cite this Report
Close
Close
Cite this article:
Chen Y, Liu S, Hou Z, et al. Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo. Nano Research, 2015, 8(6): 1917-1931. https://doi.org/10.1007/s12274-014-0701-y

1117

Views

47

Crossref

N/A

Web of Science

47

Scopus

2

CSCD
Received: 28 October 2014
Revised: 15 December 2014
Accepted: 18 December 2014
Published: 23 March 2015
© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015