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Nano Research 2015, 8(6): 1917-1931 https://doi.org/10.1007/s12274-014-0701-y
Research Article | Issue | Published: 23 March 2015

Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo

Show Author's Information Yinyin Chen1,2,  Shi Liu2,3,  Zhiyao Hou1,  Pingan Ma1,  Dongmei Yang1,2,  Chunxia Li1( ),  Jun Lin1( )
State Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130024China
University of the Chinese Academy of SciencesBeijing100049China
State Key Laboratory of Polymer Physics and ChemistryChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130024China
Keywords:
treatment, controlled release, electrospinning orthotopic, multiple structure
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Chen Y, Liu S, Hou Z, et al. Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo. Nano Research, 2015, 8(6): 1917-1931. https://doi.org/10.1007/s12274-014-0701-y
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Abstract Full text Electronic supplementary material About this article

A multifunctional, dual-drug carrier platform was successfully constructed. Core-shell structured NaGdF4: Yb/Er@NaGdF4: Yb@mSiO2-polyethylene glycol (abbreviated as UCNPS) nanoparticles loaded with the antitumor drug, doxorubicin (DOX) were incorporated into poly(ε-caprolactone) (PCL) and gelatin loaded with antiphlogistic drug, indomethacin (MC) to form nanofibrous fabrics (labeled as MC/UCNPS/DOX) via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide (SiO2) and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4: Yb/Er@NaGdF4: Yb embedded in MC/UCNPS/DOX in vivo.


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Electronic supplementary material
About this article

Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo

Show Author's information Yinyin Chen1,2, Shi Liu2,3, Zhiyao Hou1, Pingan Ma1, Dongmei Yang1,2, Chunxia Li1( ), Jun Lin1( )
State Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130024China
University of the Chinese Academy of SciencesBeijing100049China
State Key Laboratory of Polymer Physics and ChemistryChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130024China

Abstract

A multifunctional, dual-drug carrier platform was successfully constructed. Core-shell structured NaGdF4: Yb/Er@NaGdF4: Yb@mSiO2-polyethylene glycol (abbreviated as UCNPS) nanoparticles loaded with the antitumor drug, doxorubicin (DOX) were incorporated into poly(ε-caprolactone) (PCL) and gelatin loaded with antiphlogistic drug, indomethacin (MC) to form nanofibrous fabrics (labeled as MC/UCNPS/DOX) via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide (SiO2) and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4: Yb/Er@NaGdF4: Yb embedded in MC/UCNPS/DOX in vivo.

Keywords: treatment, controlled release, electrospinning orthotopic, multiple structure

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Publication history
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Acknowledgements

Publication history

Received: 28 October 2014
Revised: 15 December 2014
Accepted: 18 December 2014
Published: 23 March 2015
Issue date: June 2015

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015

Acknowledgements

Acknowledgements

This project is financially supported by the National Natural Science Foundation of China (NSFC, Nos. 51332008, 51372243, 51422209, and 51202239), the National Basic Research Program of China (No. 2014CB643803).

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