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Research Article

Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography

Yuanyuan Jiang1,§Zijian Deng2,§Dan Yang3Xin Deng1Qi Li1Yinlin Sha3( )Changhui Li2( )Dongsheng Xu1( )
Beijing National Laboratory for Molecular SciencesState Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China
Department of Biomedical EngineeringCollege of EngineeringPeking UniversityBeijing100871China
Single-molecule and Nanobiology LaboratoryDepartment of BiophysicsSchool of Basic Medical Sciencesand Biomed-X CenterPeking UniversityBeijing100191China

§These authors contributed equally to this work.

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An erratum to this article is available online at:

Graphical Abstract

Abstract

By binding molecular probes that target tumor cells, gold nanoparticles (AuNPs) with superior characteristics have shown great potential in tumor molecular imaging studies. The non-invasive, high-resolution, and three-dimensional imaging of the targeted AuNPs within the tumor is desirable for both diagnosis and therapy. In this study, gold nanoflowers (AuNFs) are presented as a novel contrast agent for photoacoustic tomography (PAT). By binding to folic acid, the molecular probe, the tail-vein injected AuNFs concentrated within the tumor site in mice; this was clearly visualized by three-dimensional (3D) PAT imaging. In addition, toxicity assay proved that AuNFs were harmless to living cells and animals. Our results demonstrate that AuNFs have great potential in tumor molecular imaging.

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Nano Research
Pages 2152-2161
Cite this article:
Jiang Y, Deng Z, Yang D, et al. Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography. Nano Research, 2015, 8(7): 2152-2161. https://doi.org/10.1007/s12274-014-0688-4

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Received: 23 July 2014
Revised: 09 December 2014
Accepted: 10 December 2014
Published: 17 July 2015
© Tsinghua University Press and Springer‐Verlag Berlin Heidelberg 2014
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