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Nano Research 2015, 8(5): 1637-1647 https://doi.org/10.1007/s12274-014-0653-2
Research Article | Issue | Published: 28 April 2015

Real-time in vivo visualization of tumor therapy by a near-infrared-Ⅱ Ag2S quantum dot-based theranostic nanoplatform

Show Author's Information Feng Hu§,  Chunyan Li§,  Yejun Zhang,  Mao Wang,  Dongming Wu,  Qiangbin Wang( )
Key Laboratory of Nano-Bio InterfaceDivision of Nanobiomedicine and i-LabSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou215123China

§ These authors contributed equally to this work.

Keywords:
drug delivery, in vivo imaging, tumor therapy, Ag2S quantum dots, second near-infrared window fluorescence
Cite this article:
Hu F, Li C, Zhang Y, et al. Real-time in vivo visualization of tumor therapy by a near-infrared-Ⅱ Ag2S quantum dot-based theranostic nanoplatform. Nano Research, 2015, 8(5): 1637-1647. https://doi.org/10.1007/s12274-014-0653-2
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Abstract Full text Electronic supplementary material About this article

Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform (DOX@PEG-Ag2S) obtained by loading the anti-cancer drug doxorubicin (DOX) into polyethylene glycol-coated silver sulfide quantum dots (PEG-Ag2S QDs) through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability (93 wt.% of DOX to Ag2S QDs), long circulation in blood (t1/2 = 10.3 h), and high passive tumor-targeting efficiency (8.9% ID/gram) in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose (ID) per gram of tissue. After targeting the tumor tissue, DOX from PEG-Ag2S cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window (NIR-Ⅱ), the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.


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Electronic supplementary material
About this article

Real-time in vivo visualization of tumor therapy by a near-infrared-Ⅱ Ag2S quantum dot-based theranostic nanoplatform

Show Author's information Feng Hu§, Chunyan Li§, Yejun Zhang, Mao Wang, Dongming Wu, Qiangbin Wang( )
Key Laboratory of Nano-Bio InterfaceDivision of Nanobiomedicine and i-LabSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou215123China

§ These authors contributed equally to this work.

Abstract

Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform (DOX@PEG-Ag2S) obtained by loading the anti-cancer drug doxorubicin (DOX) into polyethylene glycol-coated silver sulfide quantum dots (PEG-Ag2S QDs) through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability (93 wt.% of DOX to Ag2S QDs), long circulation in blood (t1/2 = 10.3 h), and high passive tumor-targeting efficiency (8.9% ID/gram) in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose (ID) per gram of tissue. After targeting the tumor tissue, DOX from PEG-Ag2S cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window (NIR-Ⅱ), the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.

Keywords: drug delivery, in vivo imaging, tumor therapy, Ag2S quantum dots, second near-infrared window fluorescence

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Publication history
Copyright
Acknowledgements

Publication history

Received: 13 October 2014
Revised: 18 November 2014
Accepted: 21 November 2014
Published: 28 April 2015
Issue date: May 2015

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015

Acknowledgements

Acknowledgements

This work was financially supported by the Chinese Academy of Sciences "Strategic Priority Research Program" (No. XDA01030200), the Ministry of Science and Technology of China (No. 2011CB965004), the National Natural Science Foundation of China (Nos. 21303249, 21301187, and 81401464), and the Natural Science Foundation of Jiangsu Province (Nos. BK2012007 and BK20130366).

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