Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents
),
Gengmei Xing(
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Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging (MRI) contrast agent. The nanohybrids showed higher R1 relaxivity and better brightening effect than Gd@C82(OH)X, in T1-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd3+ ions. A "secondary spin-electron transfer" relaxation mechanism was proposed to explain how the encaged Gd3+ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents.
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Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents
), Gengmei Xing(
)
Abstract
Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging (MRI) contrast agent. The nanohybrids showed higher R1 relaxivity and better brightening effect than Gd@C82(OH)X, in T1-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd3+ ions. A "secondary spin-electron transfer" relaxation mechanism was proposed to explain how the encaged Gd3+ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents.
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Acknowledgements
This work was supported financially by the National Basic Research Program of China (973 Program) (Nos. 2015CB932104, 2012CB932601), and the National Natural Science Foundation of China (Nos. 11405185, 21271174). We would like to acknowledge Prof. K. Ibrahim, Prof. J. Wang and other fellow research members at the Beijing Synchrotron Radiation Facility for helping with the XPS work, and X. Wang and F. Fang at Wuhan Institute of Physics and Mathematics, CAS.
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