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Nano Research 2015, 8(1): 165-174 https://doi.org/10.1007/s12274-014-0605-x
Research Article | Issue | Published: 16 December 2014

Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer

Show Author's Information Shaoheng Tang,  Mei Chen,  Nanfeng Zheng( )
State Key Laboratory for Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy Materials, and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen University, XiamenFujian361005China
Keywords:
drug delivery, photothermal therapy, synergistic effect, chemotherapy, Pd nanosheets
Cite this article:
Tang S, Chen M, Zheng N. Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer. Nano Research, 2015, 8(1): 165-174. https://doi.org/10.1007/s12274-014-0605-x
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Abstract Full text Electronic supplementary material About this article

Near-infrared (NIR) photothermal therapy has developed very quickly in recent years. However, its clinical applications are hindered by many practical problems, such as low accumulation in tumors, high laser power density and high biotoxicity in vivo. Herein, a versatile system combining chemotherapy with photothermal therapy for cancer therapy using ultrasmall Pd nanosheets (SPNS) has been developed. The SPNS can serve as pH-responsive drug carriers to efficiently deliver DOX into cancer cells and tumors. On the other hand, the coordinative loading of DOX on SPNS enhances its accumulation in tumor tissue. So we can efficiently ablate tumor using low-intensity laser radiation. Importantly, with ultrasmall size (~4.4 nm), SPNS surface-functionalized with reduced glutathione (GSH) can be cleared from the body through the renal system into the urine. This cancer therapeutic nanosystem, which exhibits a significant synergistic effect and low systemic toxicity, has great potential for clinical applications.


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Electronic supplementary material
About this article

Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer

Show Author's information Shaoheng Tang, Mei Chen, Nanfeng Zheng( )
State Key Laboratory for Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy Materials, and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen University, XiamenFujian361005China

Abstract

Near-infrared (NIR) photothermal therapy has developed very quickly in recent years. However, its clinical applications are hindered by many practical problems, such as low accumulation in tumors, high laser power density and high biotoxicity in vivo. Herein, a versatile system combining chemotherapy with photothermal therapy for cancer therapy using ultrasmall Pd nanosheets (SPNS) has been developed. The SPNS can serve as pH-responsive drug carriers to efficiently deliver DOX into cancer cells and tumors. On the other hand, the coordinative loading of DOX on SPNS enhances its accumulation in tumor tissue. So we can efficiently ablate tumor using low-intensity laser radiation. Importantly, with ultrasmall size (~4.4 nm), SPNS surface-functionalized with reduced glutathione (GSH) can be cleared from the body through the renal system into the urine. This cancer therapeutic nanosystem, which exhibits a significant synergistic effect and low systemic toxicity, has great potential for clinical applications.

Keywords: drug delivery, photothermal therapy, synergistic effect, chemotherapy, Pd nanosheets

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Publication history
Copyright
Acknowledgements

Publication history

Received: 28 August 2014
Revised: 30 September 2014
Accepted: 02 October 2014
Published: 16 December 2014
Issue date: January 2015

Copyright

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2014

Acknowledgements

Acknowledgements

We thank Prof. Xuan Zhu and Ms. Meiqin Su at Xiamen University for helping with the animal experiments. This work was supported by the Ministry of Science and Technology of China (2011CB932403, 2014CB932004), and the National Natural Science Foundation of China (21131005).

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