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Here we report a dual-functionalized electrochemical substrate to trigger cancer cells release based on the supramolecular interaction between β-cyclodextrin (β-CD) and Fc on clinical trial Ⅱ aptamer AS1411 functionalized graphene platform. On one hand, the host-guest interaction can be reversible electrochemically controlled to realize cancer cells capture/release, and 1-adamantylamine binding can further amplify this surface change by competing interaction with β-CD. On the other hand, the AS1411 aptamer and its complementary DNA (cDNA) also can be used as a switchable anchor for cell adhesion. Our work gives an example for label-free, multi-functionalized triggered cell release based on aptamer and β-CD/graphene-modified surface and this multi-ways for cell catch-and-release on graphene modified surface also provides their potential biomedical application.

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12274_2014_570_MOESM1_ESM.pdf (1.1 MB)
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Publication history

Received: 17 June 2014
Revised: 21 August 2014
Accepted: 23 August 2014
Published: 23 September 2014
Issue date: March 2015

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© Tsinghua University Press and Springer-Verlag Heidelberg 2014

Acknowledgements

Acknowledgements

Financial support was provided by the National Basic Research Program of China (973 Program) (2011CB936004, 2012CB720602), and the National Natural Science Foundation of China (NSFC) (21210002, 91213302).

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Reprints and Permission requests may be sought directly from editorial office.
Email: nanores@tup.tsinghua.edu.cn

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