A "green pathway" different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems
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Soft matter has attracted extensive attention due to its special physical/chemical properties and holds great promise in many applications. However, obtaining a detailed understanding of both complex fluid and mass transport in soft matter, especially in hierarchical porous media of biological tissues, still remains a huge challenge. Herein, inspired by fast tracer transport in loose connective tissues of living systems, we observed an interesting phenomenon of fast molecular transport in situ in an artificial hierarchical multiphase porous medium (a micrometer scale hydrophobic fiber network filled with nanometer scale hydrophilic porous medium), which was simply fabricated through electrospinning technology and polymerization. The transportation speed of molecules in the micrometer fiber network is larger than simple diffusion in nanometer media, which is better described by Fick's law. We further proved that the phenomenon is based on the nanoconfined air/water/solid interface around the micrometer hydrophobic fibers. We focus on the key factors, referring to SA, (the confined multiphase area around the microfibers) and NG (the connectivity node degree of the skeletal portion in the nanometer hydrogel medium). Next, a quantitative parameter, VTCM (transport chance mean-value), was introduced to describe the molecular transport capability of the fiber network within hierarchical multiphase porous systems. These fundamental advances can be applied de novo to understand the process of so-called simple diffusion in biological systems, and even to re-describe many molecular events in biologically nanoconfined spaces.
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A "green pathway" different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems
Abstract
Soft matter has attracted extensive attention due to its special physical/chemical properties and holds great promise in many applications. However, obtaining a detailed understanding of both complex fluid and mass transport in soft matter, especially in hierarchical porous media of biological tissues, still remains a huge challenge. Herein, inspired by fast tracer transport in loose connective tissues of living systems, we observed an interesting phenomenon of fast molecular transport in situ in an artificial hierarchical multiphase porous medium (a micrometer scale hydrophobic fiber network filled with nanometer scale hydrophilic porous medium), which was simply fabricated through electrospinning technology and polymerization. The transportation speed of molecules in the micrometer fiber network is larger than simple diffusion in nanometer media, which is better described by Fick's law. We further proved that the phenomenon is based on the nanoconfined air/water/solid interface around the micrometer hydrophobic fibers. We focus on the key factors, referring to SA, (the confined multiphase area around the microfibers) and NG (the connectivity node degree of the skeletal portion in the nanometer hydrogel medium). Next, a quantitative parameter, VTCM (transport chance mean-value), was introduced to describe the molecular transport capability of the fiber network within hierarchical multiphase porous systems. These fundamental advances can be applied de novo to understand the process of so-called simple diffusion in biological systems, and even to re-describe many molecular events in biologically nanoconfined spaces.
References(19)
Gray, W. G.; Hassanizadeh, S. M. Macroscale continuum mechanics for multiphase porous-media flow including phases, interfaces, common lines and common points. Adv. Water Resour. 1998, 21, 261–281.
Parker, J.; Lenhard, R.; Kuppusamy, T. A parametric model for constitutive properties governing multiphase flow in porous media. Water Resour. Res. 1987, 23, 618–624.
Wu, Z. L.; Gong, J. P. Hydrogels with self-assembling ordered structures and their functions. NPG Asia Mater. 2011, 3, 57–64.
Langevin, H. M. Connective tissue: A body-wide signaling network? Med. Hypotheses 2006, 66, 1074–1077.
Li, H. -Y.; Chen, M.; Yang, J. -F.; Yang, C. -Q.; Xu, L.; Wang, F.; Tong, J. B.; Lv, Y.; Suonan, C. Fluid flow along venous adventitia in rabbits: Is it a potential drainage system complementary to vascular circulations? PLOS ONE 2012, 7, e41395.
Carare, R.; Bernardes-Silva, M.; Newman, T.; Page, A.; Nicoll, J.; Perry, V.; Weller, R. Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: Significance for cerebral amyloid angiopathy and neuroimmunology. Neuropath. Appl. Neuro. 2008, 34, 131–144.
Labet, M.; Thielemans, W. Synthesis of polycaprolactone: A review. Chem. Soc. Rev. 2009, 38, 3484–3504.
Van Milligen, B. P.; Bons, P.; Carreras, B. A.; Sánchez, R. On the applicability of Fick's law to diffusion in inhomogeneous systems. Eur. J. Phys. 2005, 26, 913–925.
Sai, H.; Tan, K. W.; Hur, K.; Asenath-Smith, E.; Hovden, R.; Jiang, Y.; Riccio, M.; Muller, D. A.; Elser, V.; Estroff, L. A. Hierarchical porous polymer scaffolds from block copolymers. Science 2013, 341, 530–534.
Schwartzstein, R. M.; Parker, M. J. Respiratory Physiology: A Clinical Approach; Lippincott Williams & Wilkins: Philadelphia, 2005.
Zhang, X. H.; Maeda, N.; Craig, V. S. J. Physical properties of nanobubbles on hydrophobic surfaces in water and aqueous solutions. Langmuir 2006, 22, 5025–5035.
Poynor, A.; Hong, L.; Robinson, I. K.; Granick, S.; Zhang, Z.; Fenter, P. A. How water meets a hydrophobic surface. Phys. Rev. Lett. 2006, 97, 266101.
Siwy, Z. S.; Howorka, S. Engineered voltage-responsive nanopores. Chem. Soc. Rev. 2010, 39, 1115–1132.
Hummer, G.; Rasaiah, J. C.; Noworyta, J. P. Water conduction through the hydrophobic channel of a carbon nanotube. Nature 2001, 414, 188–190.
Majumder, M.; Chopra, N.; Andrews, R.; Hinds, B. J. Nanoscale hydrodynamics: Enhanced flow in carbon nanotubes. Nature 2005, 438, 44.
Li, C. -Y.; Ma, F. -X.; Wu, Z. -Q.; Gao, H. -L.; Shao, W. -T.; Wang, K.; Xia, X. -H. Solution-pH-modulated rectification of ionic current in highly ordered nanochannel arrays patterned with chemical functional groups at designed positions. Adv. Funct. Mater. 2013, 23, 3836–3844.
Wei, R.; Gatterdam, V.; Wieneke, R.; Tampé, R.; Rant, U. Stochastic sensing of proteins with receptor-modified solid-state nanopores. Nat. Nanotechnol. 2012, 7, 257–263.
Steinberg, R. Soft matter, slow dynamics and art. Nat. Mater. 2003, 2, 427–429.
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Acknowledgements
This study was supported by the National Natural Science Foundation of China (No. 81141118) and the National Basic Research Program of China (973 Program) (Nos. 2012CB9333800 and 2012CB518506).
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