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05 March 2010
Dopant-Controlled Synthesis of Water-Soluble Hexagonal NaYF4 Nanorods with Efficient Upconversion Fluorescence for Multicolor Bioimaging
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A novel strategy is proposed to directly synthesize water-soluble hexagonal NaYF4 nanorods by doping rare-earth ions with large ionic radius (such as La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, and Gd3+), and the dopant-controlled growth mechanism is studied. Based on the doping effect, we fabricated water-soluble hexagonal NaYF4: (Yb, Er)/La and NaYF4: (Yb, Er)/Ce nanorods, which exhibited much brighter upconversion fluorescence than the corresponding cubic forms. The sizes of the nanorods can be adjusted over a broad range by changing the dopant concentration and reaction time. Furthermore, we successfully demonstrated a novel depth-sensitive multicolor bioimaging for in vivo use by employing the as-synthesized NaYF4: (Yb, Er)/La nanorods as probes.
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Dopant-Controlled Synthesis of Water-Soluble Hexagonal NaYF4 Nanorods with Efficient Upconversion Fluorescence for Multicolor Bioimaging
)
Abstract
A novel strategy is proposed to directly synthesize water-soluble hexagonal NaYF4 nanorods by doping rare-earth ions with large ionic radius (such as La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, and Gd3+), and the dopant-controlled growth mechanism is studied. Based on the doping effect, we fabricated water-soluble hexagonal NaYF4: (Yb, Er)/La and NaYF4: (Yb, Er)/Ce nanorods, which exhibited much brighter upconversion fluorescence than the corresponding cubic forms. The sizes of the nanorods can be adjusted over a broad range by changing the dopant concentration and reaction time. Furthermore, we successfully demonstrated a novel depth-sensitive multicolor bioimaging for in vivo use by employing the as-synthesized NaYF4: (Yb, Er)/La nanorods as probes.
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Acknowledgements
The authors thank the Natural Science Foundation of China (Nos. 10534030, 10904119), the National Program on Key Science Research (No. 2006CB921500), and the China Postdoctoral Science Foundation (No. 20090451076) for support.
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