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Nano Research 2009, 2(4): 261-278 https://doi.org/10.1007/s12274-009-9025-8
Review Article | Open Access | Issue | Published: 01 April 2009

Production, Modification and Bio-Applications of Magnetic Nanoparticles Gestated by Magnetotactic Bacteria

Show Author's Information Jin Xie,  Kai Chen,  Xiaoyuan Chen( )
Department of RadiologyBio-X ProgramStanford University School of MedicineStanford, CA 94305-5484USA
Keywords:
magnetic resonance imaging (MRI), Magnetotactic bacteria (MTB), magnetosome, bio-application
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Xie J, Chen K, Chen X. Production, Modification and Bio-Applications of Magnetic Nanoparticles Gestated by Magnetotactic Bacteria. Nano Research, 2009, 2(4): 261-278. https://doi.org/10.1007/s12274-009-9025-8
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Abstract Full text About this article

Magnetotactic bacteria (MTB) were first discovered by Richard P. Blakemore in 1975, and this led to the discovery of a wide collection of microorganisms with similar features i.e., the ability to internalize Fe and convert it into magnetic nanoparticles, in the form of either magnetite (Fe3O4) or greigite (Fe3S4). Studies showed that these particles are highly crystalline, monodisperse, bioengineerable and have high magnetism that is comparable to those made by advanced synthetic methods, making them candidate materials for a broad range of bio-applications. In this review article, the history of the discovery of MTB and subsequent efforts to elucidate the mechanisms behind the magnetosome formation are briefly covered. The focus is on how to utilize the knowledge gained from fundamental studies to fabricate functional MTB nanoparticles (MTB-NPs) that are capable of tackling real biomedical problems.


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About this article

Production, Modification and Bio-Applications of Magnetic Nanoparticles Gestated by Magnetotactic Bacteria

Show Author's information Jin Xie, Kai Chen, Xiaoyuan Chen( )
Department of RadiologyBio-X ProgramStanford University School of MedicineStanford, CA 94305-5484USA

Abstract

Magnetotactic bacteria (MTB) were first discovered by Richard P. Blakemore in 1975, and this led to the discovery of a wide collection of microorganisms with similar features i.e., the ability to internalize Fe and convert it into magnetic nanoparticles, in the form of either magnetite (Fe3O4) or greigite (Fe3S4). Studies showed that these particles are highly crystalline, monodisperse, bioengineerable and have high magnetism that is comparable to those made by advanced synthetic methods, making them candidate materials for a broad range of bio-applications. In this review article, the history of the discovery of MTB and subsequent efforts to elucidate the mechanisms behind the magnetosome formation are briefly covered. The focus is on how to utilize the knowledge gained from fundamental studies to fabricate functional MTB nanoparticles (MTB-NPs) that are capable of tackling real biomedical problems.

Keywords: magnetic resonance imaging (MRI), Magnetotactic bacteria (MTB), magnetosome, bio-application

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Received: 06 December 2008
Revised: 20 January 2009
Accepted: 21 January 2009
Published: 01 April 2009
Issue date: April 2009

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