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Research Article | Open Access

A Nano- and Micro-Integrated Protein Chip Based on Quantum Dot Probes and a Microfluidic Network

Juan Yan1, Mei Hu2, Di Li1, Yao He1,2, Rui Zhao3, Xingyu Jiang3, Shiping Song1( ), Lianhui Wang2( ), Chunhai Fan1( )
Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800 China
Laboratory of Advanced Materials (LAM) Fudan University, 220 Handan RoadShanghai 200433 China
National Center for NanoScience and Technology, No. 11, Beiyitiao, Zhongguancun Beijing 100080 China
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Abstract

A novel nano- and micro-integrated protein chip (NMIPC) that can detect proteins with ultrahigh sensitivity has been fabricated. A microfluidic network (μFN) was used to construct the protein chips, which allowed facile patterning of proteins and subsequent biomolecular recognition. Aqueous phase-synthesized, water-soluble fluorescent CdTe/CdS core-shell quantum dots (aqQDs), having high quantum yield and high photostability, were used as the signaling probe. Importantly, it was found that aqQDs were compatible with microfluidic format assays, which afforded highly sensitive protein chips for cancer biomarker assays.

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Keywords

Quantum dotsmicrofluidicscarcinoma embryonic antigen (CEA)microarraypolydimethylsiloxane (PDMS)

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Nano Research
Volume 1 Issue 6,
December 2008
Pages 490-496
DOI: 10.1007/s12274-008-8052-1

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Yan J, Hu M, Li D, et al. A Nano- and Micro-Integrated Protein Chip Based on Quantum Dot Probes and a Microfluidic Network. Nano Research, 2008, 1(6): 490-496. https://doi.org/10.1007/s12274-008-8052-1

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Received: 19 August 2008
Revised: 03 November 2008
Accepted: 03 November 2008
Published: 01 December 2008
© Tsinghua Press and Springer-Verlag 2008

This article is published with open access at Springerlink.com