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Review | Open Access

Mental Health and Corresponding Interventions for Persons With Physical Disabilities: A Scoping Review

Hui Li1,2Mengqian Li1,3Hongguang Chen4Xueting Bai5Qi Qiu1Nanqi Fan5Xin Wu6Xing Wang3,7 ( )
Department of Psychosomatic Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China
Shanghai Jiao Tong University School of Medicine Affiliated Mental Health Center, Shanghai Mental Health Center, Shanghai, China
Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China
Key Laboratory of Mental Health, Peking University Sixth Hospital, Peking University Institute of Mental Health, National Health Commission, National Clinical Research Center for Mental Disorders, Beijing, China
Humanities School, Jiangxi University of Chinese Medicine, Nanchang, China
Ji'an County People's Hospital, Ji'an, China
Clinical Medicine Center, Jiangxi Medical College, Nanchang University, Nanchang, China

Hui Li, Mengqian Li and Hongguang Chen contributed equally to this work and shared the co‐first authorship.

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Abstract

Individuals with physical disabilities often face body function and structure limitations, which can increase their vulnerability to mental health problems. This scoping review, conducted in accordance with the methodological framework proposed by Arksey and O'Malley, aimed to synthesize evidence on the mental health challenges experienced by individuals with physical disabilities and to identify promising interventions for addressing these issues. A systematic literature search was performed across the PubMed, Embase, and Web of Science databases from their inception until December 31, 2021. A total of 33 studies were included in the final analysis. The findings identified depression, anxiety, posttraumatic stress disorder, substance use disorders, sleep disturbances, eating disorders, and psychological distress as prevalent mental health concerns within this population. Notably, considerable heterogeneity was observed across the included studies regarding sample sizes, assessment methodologies, and overall representativeness. The identified interventions were categorized into five primary domains: psychotherapy, physical therapy, recreational therapy, group‐based training, and multimodal treatment approaches. Specific modalities, including acceptance and commitment therapy, recreational therapies, and internet‐based interventions, demonstrated potential efficacy in improving psychological outcomes. In conclusion, the management of mental health in individuals with physical disabilities presents significant ongoing challenges. While emerging interventions show therapeutic promise, the current evidence base is constrained by a preponderance of small‐scale studies and a paucity of robust randomized controlled trials necessary to definitively evaluate their effectiveness and implementation feasibility.

Graphical Abstract

This scoping review of 33 studies maps the landscape of mental health in persons with physical disabilities. It finds a high prevalence of depression, anxiety, posttraumatic stress disorder, and other psychological problems, but highlights significant heterogeneity across studies in sample size, measurement, and representativeness. Promising interventions such as acceptance and commitment therapy, recreational therapies, and internet‐based approaches are identified, underscoring the need for larger, rigorous trials to establish efficacy and the urgency of developing effective population‐level strategies.

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Medicine Advances
Pages 136-149

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Cite this article:
Li H, Li M, Chen H, et al. Mental Health and Corresponding Interventions for Persons With Physical Disabilities: A Scoping Review. Medicine Advances, 2026, 4(2): 136-149. https://doi.org/10.1002/med4.70057

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Received: 19 May 2025
Revised: 28 August 2025
Accepted: 25 September 2025
Published: 25 April 2026
© 2026 The Author(s). Tsinghua University Press.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.