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Medicine Advances 2023, 1(1): 3-13 https://doi.org/10.1002/med4.7
Clinical Guideline | Open Access | Issue | Published: 24 March 2023

Expert consensus on treatment for stage Ⅲ non-small cell lung cancer

Show Author's Information Yi-Long Wu1,2( ),  Shun Lu3,  Qinghua Zhou4,  Li Zhang5,  Ying Cheng6,  Jie Wang7,  Buhai Wang8,  Chengping Hu9,  Lizhu Lin10,  Wenzhao Zhong1,  Yong Song11,  Nong Yang12,  Xiaorong Dong13,  Jian Zhao14,  Haihong Yang15,  Hui Guo16,  Xiaolong Yan17,  Hongxu Liu18,  Rui Ma18,  Jie Lin19,  Siyang Liu1,  Chun Chen20,  Lifeng Wang21,  Chengzhi Zhou15,  Ming Zhou14,  Fang Wu22,  Xue-Ning Yang1,  Yingying Du23,  Yu Yao16,  Yang Shao24,  Shaodong Hong5,  Jiuwei Cui25,  Xueping Quan26,  Rongrong Chen27,  Jiayan Wu28,  Jiatao Zhang1,  Jianya Zhou29,  Binchao Wang1,  Chao Cheng30,  Huijuan Wang31,  Jingjing Liu6,  Lin Wu12,  Yan Huang5,  Yukun Kuang30,  Yongchang Zhang12,  Jia Hu32,  Jinji Yang1,  Weineng Feng33,  Wenmei Su34,  Yun Fan35,  Fan Yang36,  Ming Chen5,  Kejing Tang30,  Yi Pan1,  Peng Shen37,  Anwen Liu38,  Haibo Zhang39,  Wenhua Liang15,  Qing Zhou1,  Zhiyong Ma31,  Xiuyu Cai5,  Hui Liu5,  Longfei Chen40,  Shaokun Chuai40,  Jianzhen Shan29,  Yanfang Zheng14,  Changxuan You37,  Xiaoxia Zhu41,  Li Li42,  Tongmei Zhang43,  Haiyan Tu1,  Wurong Lin44,  Xuchao Zhang1,  Penghui Zhou5,  Zunfu Ke30,  Huiying Liang1
Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Chinese Association of Lung Cancer (CALC), Guangdong Association of Clinical Trials (GACT)/Chinese Thoracic Oncology Group (CTONG), Guangzhou, China
Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China
Lung Cancer Institute/Lung Cancer Center, West, China Hospital, Sichuan University, Chengdu, Sichuan, China
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
Jilin Cancer Hospital, Changchun, Jilin, China
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China
Subei People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China
Xiangya Hospital of Central South University, Changsha, Hunan, China
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China
Jinling Hospital of Nanjing University School of Medicine, Nanjing, China
Department of Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
Union Hospital Affiliated to Tongji Medicine College of Huazhong University of Science and Technology, Wuhan, Hubei, China
Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China
Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China
Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
Fujian Medical University Union Hospital, Fuzhou, Fujian, China
The Affiliated Drum Tower Hospital of Nanjing University Medicine School, Nanjing, Jiangsu, China
The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
The First Affiliated Hospital of Anhui Medical University, Hefei, China
Geneseeq Technology Inc., Nanjing, Jiangsu, China
The First Bethune Hospital of Jilin University, Changchun, Jilin, China
Shanghai Tongshu Biotechnology Co., Ltd., Shanghai, China
Beijing GenePlus Technology Co., Ltd., Beijing, China
Berry Oncology Co., Ltd, Fuzhou, Fujian, China
The First Affiliated Hospital of College of Medicine of Zhejiang University, Hangzhou, Zhejian, China
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
Zhongshan Hospital Affiliated to Fudan University, Shanghai, China
The First People's Hospital of Foshan, Foshan, Guangdong, China
Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Cancer Hospital of the University of Chinese Academy of Sciences/Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
Peking University People's Hospital, Beijing, China
Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China
Guangzhou Burning Rock Biotech Co., Ltd., Guangzhou, Guangdong, China
Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China
Daping Hospital of Army Medical University, Chongqing, China
Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China
OrigiMed Shanghai Co., Ltd., Shanghai, China
Keywords:
consensus, multiple disciplinary comprehensive treatment, stage Ⅲ non-small cell lung cancer
Cite this article:
Wu Y-L, Lu S, Zhou Q, et al. Expert consensus on treatment for stage Ⅲ non-small cell lung cancer. Medicine Advances, 2023, 1(1): 3-13. https://doi.org/10.1002/med4.7
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Abstract Full text About this article

Stage Ⅲ non-small cell lung cancer (NSCLC) encompasses a group of diseases with high heterogeneity. Such patients should actively receive comprehensive treatments. It is imperative for all stage Ⅲ NSCLC patients to receive consultation with a multiple disciplinary team, which allows the development of a proposal for clinical diagnosis and treatment. In this consensus, stage Ⅲ NSCLC is divided into two types (operable and inoperable) according to different clinical conditions. Resectable NSCLC is further subdivided into two conditions (with or without driver genes). For each clinical scenario, this consensus emphasizes that the foundation of any medical decisions regarding the optimal diagnostic or therapy procedure is scientific evidence from clinical research. Finally, based on the level of evidence and strength of recommendations, this consensus provides recommendations for the management of stage Ⅲ NSCLC from six perspectives. The objective of this consensus is to help clinicians choose the best treatment and promote the standardization of stage Ⅲ NSCLC diagnosis and treatment in China.


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About this article

Expert consensus on treatment for stage Ⅲ non-small cell lung cancer

Show Author's information Yi-Long Wu1,2( ), Shun Lu3, Qinghua Zhou4, Li Zhang5, Ying Cheng6, Jie Wang7, Buhai Wang8, Chengping Hu9, Lizhu Lin10, Wenzhao Zhong1, Yong Song11, Nong Yang12, Xiaorong Dong13, Jian Zhao14, Haihong Yang15, Hui Guo16, Xiaolong Yan17, Hongxu Liu18, Rui Ma18, Jie Lin19, Siyang Liu1, Chun Chen20, Lifeng Wang21, Chengzhi Zhou15, Ming Zhou14, Fang Wu22, Xue-Ning Yang1, Yingying Du23, Yu Yao16, Yang Shao24, Shaodong Hong5, Jiuwei Cui25, Xueping Quan26, Rongrong Chen27, Jiayan Wu28, Jiatao Zhang1, Jianya Zhou29, Binchao Wang1, Chao Cheng30, Huijuan Wang31, Jingjing Liu6, Lin Wu12, Yan Huang5, Yukun Kuang30, Yongchang Zhang12, Jia Hu32, Jinji Yang1, Weineng Feng33, Wenmei Su34, Yun Fan35, Fan Yang36, Ming Chen5, Kejing Tang30, Yi Pan1, Peng Shen37, Anwen Liu38, Haibo Zhang39, Wenhua Liang15, Qing Zhou1, Zhiyong Ma31, Xiuyu Cai5, Hui Liu5, Longfei Chen40, Shaokun Chuai40, Jianzhen Shan29, Yanfang Zheng14, Changxuan You37, Xiaoxia Zhu41, Li Li42, Tongmei Zhang43, Haiyan Tu1, Wurong Lin44, Xuchao Zhang1, Penghui Zhou5, Zunfu Ke30, Huiying Liang1
Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Chinese Association of Lung Cancer (CALC), Guangdong Association of Clinical Trials (GACT)/Chinese Thoracic Oncology Group (CTONG), Guangzhou, China
Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China
Lung Cancer Institute/Lung Cancer Center, West, China Hospital, Sichuan University, Chengdu, Sichuan, China
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
Jilin Cancer Hospital, Changchun, Jilin, China
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China
Subei People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China
Xiangya Hospital of Central South University, Changsha, Hunan, China
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China
Jinling Hospital of Nanjing University School of Medicine, Nanjing, China
Department of Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
Union Hospital Affiliated to Tongji Medicine College of Huazhong University of Science and Technology, Wuhan, Hubei, China
Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China
Department of Thoracic Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China
Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China
The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
Fujian Medical University Union Hospital, Fuzhou, Fujian, China
The Affiliated Drum Tower Hospital of Nanjing University Medicine School, Nanjing, Jiangsu, China
The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
The First Affiliated Hospital of Anhui Medical University, Hefei, China
Geneseeq Technology Inc., Nanjing, Jiangsu, China
The First Bethune Hospital of Jilin University, Changchun, Jilin, China
Shanghai Tongshu Biotechnology Co., Ltd., Shanghai, China
Beijing GenePlus Technology Co., Ltd., Beijing, China
Berry Oncology Co., Ltd, Fuzhou, Fujian, China
The First Affiliated Hospital of College of Medicine of Zhejiang University, Hangzhou, Zhejian, China
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
Zhongshan Hospital Affiliated to Fudan University, Shanghai, China
The First People's Hospital of Foshan, Foshan, Guangdong, China
Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Cancer Hospital of the University of Chinese Academy of Sciences/Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
Peking University People's Hospital, Beijing, China
Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China
Guangzhou Burning Rock Biotech Co., Ltd., Guangzhou, Guangdong, China
Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China
Daping Hospital of Army Medical University, Chongqing, China
Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China
OrigiMed Shanghai Co., Ltd., Shanghai, China

Abstract

Stage Ⅲ non-small cell lung cancer (NSCLC) encompasses a group of diseases with high heterogeneity. Such patients should actively receive comprehensive treatments. It is imperative for all stage Ⅲ NSCLC patients to receive consultation with a multiple disciplinary team, which allows the development of a proposal for clinical diagnosis and treatment. In this consensus, stage Ⅲ NSCLC is divided into two types (operable and inoperable) according to different clinical conditions. Resectable NSCLC is further subdivided into two conditions (with or without driver genes). For each clinical scenario, this consensus emphasizes that the foundation of any medical decisions regarding the optimal diagnostic or therapy procedure is scientific evidence from clinical research. Finally, based on the level of evidence and strength of recommendations, this consensus provides recommendations for the management of stage Ⅲ NSCLC from six perspectives. The objective of this consensus is to help clinicians choose the best treatment and promote the standardization of stage Ⅲ NSCLC diagnosis and treatment in China.

Keywords: consensus, multiple disciplinary comprehensive treatment, stage Ⅲ non-small cell lung cancer

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Publication history
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Acknowledgements
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Publication history

Received: 16 February 2023
Accepted: 21 February 2023
Published: 24 March 2023
Issue date: March 2023

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© 2023 The Authors. Tsinghua University Press.

Acknowledgements

ACKNOWLEDGMENTS

This work was supported by the National Natural ScienceFoundation of China (Grant No. 82072562 to Qing Zhou),the High level Hospital Construction Project (Grant No.DFJH201810 to Qing Zhou), the Key Lab System Project ofGuangdong Science and Technology Department,Guangdong Provincial Key Lab of Translational Medicinein Lung Cancer (Grant No. 2017B030314120 to Yi‐LongWu).

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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, providedthe original work is properly cited.

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