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Medicine Advances 2023, 1(2): 158-162 https://doi.org/10.1002/med4.26
Commentary | Open Access | Issue | Published: 22 June 2023

A glimpse of recent advances in the research of acute kidney injury

Show Author's Information Zheng Dong1,2( ),  Xinling Liang3
Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Medical Research, Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA
Department of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
Keywords:
acute kidney injury, acute renal failure, renal tubular epithelial cells
Cite this article:
Dong Z, Liang X. A glimpse of recent advances in the research of acute kidney injury. Medicine Advances, 2023, 1(2): 158-162. https://doi.org/10.1002/med4.26
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Abstract Full text About this article

Acute kidney injury (AKI) is a major renal disease that affects 13 million people and is associated with almost 1.7 million deaths each year around the world. Previously referred to as acute renal failure, AKI is defined not only by a rapid functional decline of the kidney but also by pathological damages in kidney tissue. This updated definition contributes to modern renal medicine in at least two ways. First, the definition of AKI includes an early, preventable and treatable stage of the disease, which implies an urgent need for sensitive biomarkers for early diagnosis and treatment. Second, the AKI definition is proposed with clear criteria for diagnosis and severity grading, which are beneficial for clinical studies and the meta‐analysis of different datasets.


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About this article

A glimpse of recent advances in the research of acute kidney injury

Show Author's information Zheng Dong1,2( ), Xinling Liang3
Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, USA
Department of Medical Research, Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA
Department of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

Abstract

Acute kidney injury (AKI) is a major renal disease that affects 13 million people and is associated with almost 1.7 million deaths each year around the world. Previously referred to as acute renal failure, AKI is defined not only by a rapid functional decline of the kidney but also by pathological damages in kidney tissue. This updated definition contributes to modern renal medicine in at least two ways. First, the definition of AKI includes an early, preventable and treatable stage of the disease, which implies an urgent need for sensitive biomarkers for early diagnosis and treatment. Second, the AKI definition is proposed with clear criteria for diagnosis and severity grading, which are beneficial for clinical studies and the meta‐analysis of different datasets.

Keywords: acute kidney injury, acute renal failure, renal tubular epithelial cells

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Published: 22 June 2023
Issue date: June 2023

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© 2023 The Authors. Tsinghua University Press.

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