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Original Article | Open Access

Serological Indicators and Survival Analysis of Synaptophysin‐Positive Gastric Cancer Patients: A Retrospective Study

Xuemei Wei1 , Xu Zhang1 , Jiaqi Zhang2, Lin Zhu1 , Guanghong Guo1( )
Department of Clinical Laboratory, The First Medical Center of Chinese PLA General Hospital Beijing, Beijing, China
The First Clinical Medical College, Ningxia Medical University, Yinchuan, China

Xuemei Wei and Xu Zhang contributed equally to this work and shared the co‐first authorship.

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Abstract

Background

This study aims to determine prognostic indicators of synaptophysin (SYN) positive gastric cancer with neuroendocrine type by analyzing differences in serological indicators and survival between SYN‐positive and SYN‐negative gastric cancer patients and to provide a theoretical basis for the prognosis of patients.

Methods

The medical records of 1298 gastric cancer patients who had received surgical treatment between January 2019 and December 2021 at The First Medical Center of Chinese PLA General Hospital were assessed, and 59 patients were enrolled in this study, to analyze serological indices and survival differences between patients with SYN‐positive and SYN‐negative gastric cancer.

Results

There were statistically significant differences between the expression of SYN and genetic history, tumor differentiation degree, and Lauren's typing (p = 0.036, 0.040, and 0.017, respectively). The level of neuron‐specific enolase in SYN‐positive patients was higher than that in SYN‐negative patients (p = 0.027). The level of hemoglobin (Hb) and mean corpuscular hemoglobin (MCH) was lower in SYN‐positive patients when compared with SYN‐negative patients (p = 0.023 and 0.019, respectively). The survival time of SYN‐positive gastric cancer patients was statistically significantly different from that of SYN‐negative gastric cancer patients (p = 0.0255).

Conclusions

SYN expression in patients with gastric cancer is correlated with the degree of differentiation and Lauren's typing. The prognosis of SYN‐positive gastric cancer patients is worse than that of SYN‐negative patients.

Graphical Abstract

SYN expression in patients with gastric cancer is correlated with the degree of differentiation and Lauren's typing. The prognosis of SYN‐positive gastric cancer patients is worse than that of SYN‐negative patients.

Keywords

degree of differentiationGC‐NEFlauren classificationsurvival curveSYN

References

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iLABMED
Volume 3 Issue 2,
June 2025
Pages 221-229
DOI: 10.1002/ila2.70008

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Cite this article:
Wei X, Zhang X, Zhang J, et al. Serological Indicators and Survival Analysis of Synaptophysin‐Positive Gastric Cancer Patients: A Retrospective Study. iLABMED, 2025, 3(2): 221-229. https://doi.org/10.1002/ila2.70008

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Received: 05 October 2024
Revised: 29 December 2024
Accepted: 20 January 2025
Published: 12 April 2025
© 2025 The Author(s). Tsinghua University Press.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.